"Kuba, A." . . "[7713205F6660]" . "Zapletalov\u00E1, J." . . . . "RIV/00843989:_____/12:00103107!RIV13-MZ0-00843989" . . "S, V, Z(MSM6198959205), Z(MSM6198959223)" . . . "000304312600006" . "Operational cures after interferon-alpha in patients with chronic myeloid leukemia in Central and Northern Moravia" . "Ro\u017Emanov\u00E1, \u0160." . . "10.1089/jir.2011.0108" . . . . "Divok\u00E1, M." . . . . . "Operational cures after interferon-alpha in patients with chronic myeloid leukemia in Central and Northern Moravia" . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "1079-9907" . . "chronic myelogenous leukemia; fusion gene transcripts; residual disease; responses; imatinib; cells"@en . . . . "Holzerov\u00E1, M." . "32" . "Roho\u0148, P." . "Operational cures after interferon-alpha in patients with chronic myeloid leukemia in Central and Northern Moravia"@en . "58"^^ . "Journal of interferon & cytokine research" . . "Gumulec, Jarom\u00EDr" . . "We assessed long-term outcome of 118 consecutive patients in chronic phase of chronic myeloid leukemia (CML) treated with interferon-alpha (IFN-alpha) in the Central and Northern Moravia region between 1989 and 2006 with focus on operational cure. The median follow-up was 82.6 months (range 12.4-212.6). Eighteen (15.3%) patients achieved complete cytogenetic response (CCyR) after median 16.7 (3.7-40.8) months. Nine of these patients (7.6%) achieved BCR-ABL negativity in nested reverse transcriptase-polymerase chain reaction [%22complete'' molecular response (CMR)] and 6 of them have been operationally cured without any treatment for median 6 (4-10) years, while 2 continue with IFN-alpha and 1 died from CML-unrelated cause. Operationally cured patients had a significantly lower percentage of initial peripheral promyelocytes, blasts, and erythroblasts than the rest of patients treated for more than 12 months (P=0.01-0.03). Unlike patients with sole CCyR, the majority of whom lost CCyR despite continuing IFN-alpha therapy and required imatinib, patients who achieved CMR had excellent long-term outcome." . "5"^^ . "3"^^ . "5" . . "Operational cures after interferon-alpha in patients with chronic myeloid leukemia in Central and Northern Moravia"@en . "We assessed long-term outcome of 118 consecutive patients in chronic phase of chronic myeloid leukemia (CML) treated with interferon-alpha (IFN-alpha) in the Central and Northern Moravia region between 1989 and 2006 with focus on operational cure. The median follow-up was 82.6 months (range 12.4-212.6). Eighteen (15.3%) patients achieved complete cytogenetic response (CCyR) after median 16.7 (3.7-40.8) months. Nine of these patients (7.6%) achieved BCR-ABL negativity in nested reverse transcriptase-polymerase chain reaction [%22complete'' molecular response (CMR)] and 6 of them have been operationally cured without any treatment for median 6 (4-10) years, while 2 continue with IFN-alpha and 1 died from CML-unrelated cause. Operationally cured patients had a significantly lower percentage of initial peripheral promyelocytes, blasts, and erythroblasts than the rest of patients treated for more than 12 months (P=0.01-0.03). Unlike patients with sole CCyR, the majority of whom lost CCyR despite continuing IFN-alpha therapy and required imatinib, patients who achieved CMR had excellent long-term outcome."@en . "Jaro\u0161ov\u00E1, M." . "Indr\u00E1k, K." . . "Faber, E." . "Matu\u0161ka, Milan" . "Blahutov\u00E1, \u0160\u00E1rka" . "RIV/00843989:_____/12:00103107" . "156679" .