. "Prim\u00E1rn\u00ED neuroendokrinn\u00ED karcinom jater pat\u0159\u00ED ke vz\u00E1cn\u011B se vyskytuj\u00EDc\u00EDm n\u00E1dor\u016Fm, kter\u00FD pravd\u011Bpodobn\u011B vych\u00E1z\u00ED z roztrou\u0161en\u00FDch neuroendokrinn\u00EDch bun\u011Bk \u017Elu\u010Dov\u00FDch cest. V na\u0161em p\u0159\u00EDpad\u011B \u0161lo o 72-let\u00E9ho mu\u017Ee, u kter\u00E9ho doch\u00E1zelo postupn\u011B k \u00FAbytku v\u00E1hy a k pr\u016Fjm\u016Fm. Vzhledem k tomu, \u017Ee pacient pob\u00FDval v Dominik\u00E1nsk\u00E9 republice, pom\u00FD\u0161lelo se na parazit\u00E1rn\u00ED onemocn\u011Bn\u00ED. To se v\u0161ak neprok\u00E1zalo. Dal\u0161\u00EDm vy\u0161et\u0159en\u00EDm byla zji\u0161t\u011Bna n\u00E1dorov\u00E1 infiltrace jater. Byl proveden cytologick\u00FD odb\u011Br tenkou jehlou z m\u00EDsta n\u00E1doru. Vy\u0161et\u0159en\u00ED uk\u00E1zalo, \u017Ee se jedn\u00E1 o neuroendokrinn\u00ED karcinom. N\u00E1dorov\u00E9 bu\u0148ky exprimovaly neuroendokrinn\u00ED markery (chromogranin, synaptofyzin, CD56 a NSE) stejn\u011B tak i epitelov\u00FD marker AE1-AE3. N\u00E1dor byl pova\u017Eov\u00E1n za metast\u00E1zu prim\u00E1rn\u00EDho n\u00E1doru, kter\u00FD se pravd\u011Bpodobn\u011B nach\u00E1z\u00ED v gastrointestin\u00E1ln\u00EDm traktu. Pacient se podrobil zevrubn\u00E9mu klinick\u00E9mu vy\u0161et\u0159en\u00ED v\u010Detn\u011B gastroskopie, kolonoskopie, 111In-oktreoskenov\u00E9 scintigrafii, po\u010D\u00EDta\u010Dov\u00E9 tomografii a vy\u0161et\u0159en\u00ED magnetickou rezonanc\u00ED. Metody uk\u00E1zaly metast\u00E1zy v obratlech, p\u00E1nvi, dlouh\u00FDch kostech a lebce. \u017Dadn\u00E9 dal\u0161\u00ED n\u00E1dorov\u00E9 lo\u017Eisko v plic\u00EDch, v gastrointestin\u00E1ln\u00EDm traktu nebo v pankreatu nebylo zji\u0161t\u011Bno. Pacient postupn\u011B kachektizoval a zem\u0159el. Pitva uk\u00E1zala masivn\u00ED multicentrickou n\u00E1dorovou infiltraci jater. Histologicky \u0161lo o dob\u0159e diferencovan\u00FD neuroendokrinn\u00ED karcinom, kter\u00FD p\u0159ech\u00E1zel do intermedi\u00E1ln\u00EDch a\u017E mal\u00FDch bun\u011Bk. V gastrointestin\u00E1ln\u00EDm traktu, plic\u00EDch a ani v pankreatu se p\u0159i pitv\u011B \u017E\u00E1dn\u00E9 n\u00E1dorov\u00E9 lo\u017Eisko nena\u0161lo. Domn\u00EDv\u00E1me se, \u017Ee \u0161lo o prim\u00E1rn\u00ED neuroendokrinn\u00ED karcinom jater." . . "1" . "neuroendocrine carcinoma; liver; primary tumour"@en . "Dvo\u0159\u00E1\u010Dkov\u00E1, Jana" . . "48" . "5"^^ . . "161636" . "Primary hepatic neuroendocrine carcinoma"@en . "Prim\u00E1rn\u00ED neuroendokrinn\u00ED karcinom jater" . "Primary neuroendocrine carcinoma of the liver is a rare tumour, probably arising from scattered neuroendocrine cells of the bile duct. We present the case of a 72-year-old male who experienced gradual weight loss and diarrhoea. Given the fact that he had stayed in the Dominican republic, a parasitic disease was initially suspected. However, this was not confirmed. Further examination showed tumour infilatration of the liver. Fine needle aspiration cytology of the tumour site was performed. The diagnostic procedure revealed neuroendocrine carcinoma. The tumour cells expressed the following neuroendocrine markers (chromogranin, synaptophysin, CD56 and NSE) as well as the epithelial marker AE1-AE3. The tumour was considered metastasis of the primary tumour located in the gastrointestinal tract. A thorough clinical examination was performed including gastroscopy, colonoscopy, In-111 Octreoscan scintigraphy, computed tomography and magnetic resonance imaging. these methods revealed metastases in the vertebrae, pelvis, long bones and skull. No other tumour sites were found in the lungs, gastrointestinal tract or pancreas. The patient became increasingly cachexis and later died. An autopsy showed massie multicentric tumour infiltration of the liver. Histological examination revealed well differentiated neuroendocrine carcinoma which transformed into intermediate and small cells. The autopsy found no tumour sites in the gastrointestinal tract, lungs or pancreas. The results were suggestive of primary neuroendocrine carcinoma of the liver."@en . "5"^^ . "Ma\u010D\u00E1k, Jirka" . "Fakhouri, F\u00E1di" . . . . "CZ - \u010Cesk\u00E1 republika" . "Prim\u00E1rn\u00ED neuroendokrinn\u00ED karcinom jater"@cs . . . . "1210-7875" . . "[AA20BFE28C42]" . "\u010Cesko-slovensk\u00E1 patologie a soudn\u00ED l\u00E9ka\u0159stv\u00ED" . . "Prim\u00E1rn\u00ED neuroendokrinn\u00ED karcinom jater pat\u0159\u00ED ke vz\u00E1cn\u011B se vyskytuj\u00EDc\u00EDm n\u00E1dor\u016Fm, kter\u00FD pravd\u011Bpodobn\u011B vych\u00E1z\u00ED z roztrou\u0161en\u00FDch neuroendokrinn\u00EDch bun\u011Bk \u017Elu\u010Dov\u00FDch cest. V na\u0161em p\u0159\u00EDpad\u011B \u0161lo o 72-let\u00E9ho mu\u017Ee, u kter\u00E9ho doch\u00E1zelo postupn\u011B k \u00FAbytku v\u00E1hy a k pr\u016Fjm\u016Fm. Vzhledem k tomu, \u017Ee pacient pob\u00FDval v Dominik\u00E1nsk\u00E9 republice, pom\u00FD\u0161lelo se na parazit\u00E1rn\u00ED onemocn\u011Bn\u00ED. To se v\u0161ak neprok\u00E1zalo. Dal\u0161\u00EDm vy\u0161et\u0159en\u00EDm byla zji\u0161t\u011Bna n\u00E1dorov\u00E1 infiltrace jater. Byl proveden cytologick\u00FD odb\u011Br tenkou jehlou z m\u00EDsta n\u00E1doru. Vy\u0161et\u0159en\u00ED uk\u00E1zalo, \u017Ee se jedn\u00E1 o neuroendokrinn\u00ED karcinom. N\u00E1dorov\u00E9 bu\u0148ky exprimovaly neuroendokrinn\u00ED markery (chromogranin, synaptofyzin, CD56 a NSE) stejn\u011B tak i epitelov\u00FD marker AE1-AE3. N\u00E1dor byl pova\u017Eov\u00E1n za metast\u00E1zu prim\u00E1rn\u00EDho n\u00E1doru, kter\u00FD se pravd\u011Bpodobn\u011B nach\u00E1z\u00ED v gastrointestin\u00E1ln\u00EDm traktu. Pacient se podrobil zevrubn\u00E9mu klinick\u00E9mu vy\u0161et\u0159en\u00ED v\u010Detn\u011B gastroskopie, kolonoskopie, 111In-oktreoskenov\u00E9 scintigrafii, po\u010D\u00EDta\u010Dov\u00E9 tomografii a vy\u0161et\u0159en\u00ED magnetickou rezonanc\u00ED. Metody uk\u00E1zaly metast\u00E1zy v obratlech, p\u00E1nvi, dlouh\u00FDch kostech a lebce. \u017Dadn\u00E9 dal\u0161\u00ED n\u00E1dorov\u00E9 lo\u017Eisko v plic\u00EDch, v gastrointestin\u00E1ln\u00EDm traktu nebo v pankreatu nebylo zji\u0161t\u011Bno. Pacient postupn\u011B kachektizoval a zem\u0159el. Pitva uk\u00E1zala masivn\u00ED multicentrickou n\u00E1dorovou infiltraci jater. Histologicky \u0161lo o dob\u0159e diferencovan\u00FD neuroendokrinn\u00ED karcinom, kter\u00FD p\u0159ech\u00E1zel do intermedi\u00E1ln\u00EDch a\u017E mal\u00FDch bun\u011Bk. V gastrointestin\u00E1ln\u00EDm traktu, plic\u00EDch a ani v pankreatu se p\u0159i pitv\u011B \u017E\u00E1dn\u00E9 n\u00E1dorov\u00E9 lo\u017Eisko nena\u0161lo. Domn\u00EDv\u00E1me se, \u017Ee \u0161lo o prim\u00E1rn\u00ED neuroendokrinn\u00ED karcinom jater."@cs . "RIV/00843989:_____/12:00102251!RIV13-MZ0-00843989" . "Primary hepatic neuroendocrine carcinoma"@en . . "Prim\u00E1rn\u00ED neuroendokrinn\u00ED karcinom jater" . "Hor\u00E1\u010Dek, Jaroslav" . . "Pl\u00E1\u0161ek, Ji\u0159\u00ED" . . . "Prim\u00E1rn\u00ED neuroendokrinn\u00ED karcinom jater"@cs . "RIV/00843989:_____/12:00102251" . . . "4"^^ . . "V" .