"Udr\u017Eovac\u00ED l\u00E9\u010Dba Crohnovy choroby p\u0159edstavuje pou\u017Eit\u00ED imunosupresivn\u00ED l\u00E9\u010Dby, kter\u00E1 je asociov\u00E1na s vy\u0161\u0161\u00EDm rizikem infekc\u00ED. Prioritou je identifikace bezpe\u010Dn\u00FDch a efektivn\u00EDch udr\u017Eovac\u00EDch strategi\u00ED. C\u00EDl: Ur\u010Den\u00ED jeli or\u00E1ln\u00ED pod\u00E1v\u00E1n\u00ED omega-3 voln\u00FDch mastn\u00FDch kyselin efektivn\u011Bj\u0161\u00ED ne\u017E placebo v prevenci relaps\u016F Crohnovy choroby. Design, soubor pacient\u016F: 2 randomizovan\u00E9, dvojit\u011B slep\u00E9, placebem kontrolovan\u00E9 studie (Epanova program v Crohn studii 1[EPIC-1] a EPIC-2) , kter\u00E9 prob\u00EDhaly od ledna 2003 do \u00FAnoru 2007 v 98 centrech v Kanad\u011B, Evrop\u011B, Izraeli a Spojen\u00FDch st\u00E1tech. Data od 363 a 375 pacient\u016F s Crohnovou chorobou v remisi byly zhodnoceny v EPIC-1 a EPIC-2. Intervence: pacienti s aktivitou Crohnovy choroby hodnocen\u00E9 podle CDAI sk\u00F3re (Crohn disease activity index) men\u0161\u00ED ne\u017E 150 byli randomizov\u00E1ni k l\u00E9\u010Db\u011B bu\u010F 4g/denn\u011B omega-3 mastn\u00FDch kyselin \u010Di placebem po 58 t\u00FDdn\u016F. Hlavn\u00ED sledovan\u00E9 parametry: Klinick\u00FD relaps, definovan\u00FD jako n\u00E1r\u016Fst hodnoty CDAI sk\u00F3re nad 150 \u010Di o 70 bod\u016F od v\u00FDchoz\u00ED h"@cs . "RIV/00843989:_____/08:00015969" . . "Dallaire, Ch." . "RIV/00843989:_____/08:00015969!RIV09-MZ0-00843989" . "H\u00E9buterne, X." . "384500" . "Mittmann, U." . . "Par\u00E9, P." . "0098-7484" . "14" . "inflammatory bowel disease; complementary medicine use; coronary heart disease; dose omega-3 fatty acids; rheumatoid arthritis"@en . . "Maintenance therapy for Crohn disease features the use of immunosuppressive drugs, which are associated with an increased risk of infection. Identification of safe and effective maintenance strategies is a priority. OBJECTIVE: To determine whether the oral administration of omega-3 free fatty acids is more effective than placebo for prevention of relapse of Crohn disease. DESIGN, SETTING, AND PATIENTS: Two randomized, double-blind, placebo-controlled studies (Epanova Program in Crohn's Study 1 [EPIC-1] and EPIC-2) conducted between January 2003 and February 2007 at 98 centers in Canada, Europe, Israel, and the United States. Data from 363 and 375 patients with quiescent Crohn disease were evaluated in EPIC-1 and EPIC-2, respectively. INTERVENTIONS: Patients with a Crohn's Disease Activity Index (CDAI) score of less than 150 were randomly assigned to receive either 4 g/d of omega-3 free fatty acids or placebo for up to 58 weeks. No other treatments for Crohn disease were permit"@en . . . "Klva\u0148a, Pavel" . "8"^^ . "[143185D6CCA4]" . "000254749600025" . "Omega \u20133 voln\u00E9 mastn\u00E9 kyseliny k udr\u017Een\u00ED remise Crohnovy choroby"@cs . "Ponich, T. P." . "Maintenance therapy for Crohn disease features the use of immunosuppressive drugs, which are associated with an increased risk of infection. Identification of safe and effective maintenance strategies is a priority. OBJECTIVE: To determine whether the oral administration of omega-3 free fatty acids is more effective than placebo for prevention of relapse of Crohn disease. DESIGN, SETTING, AND PATIENTS: Two randomized, double-blind, placebo-controlled studies (Epanova Program in Crohn's Study 1 [EPIC-1] and EPIC-2) conducted between January 2003 and February 2007 at 98 centers in Canada, Europe, Israel, and the United States. Data from 363 and 375 patients with quiescent Crohn disease were evaluated in EPIC-1 and EPIC-2, respectively. INTERVENTIONS: Patients with a Crohn's Disease Activity Index (CDAI) score of less than 150 were randomly assigned to receive either 4 g/d of omega-3 free fatty acids or placebo for up to 58 weeks. No other treatments for Crohn disease were permit" . "Omega \u20133 voln\u00E9 mastn\u00E9 kyseliny k udr\u017Een\u00ED remise Crohnovy choroby"@cs . "Cohen, A." . . "Omega-3 Free Fatty Acids for the Maintenance of Remission in Crohn Disease" . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "Omega-3 Free Fatty Acids for the Maintenance of Remission in Crohn Disease" . . "299" . "Omega-3 Free Fatty Acids for the Maintenance of Remission in Crohn Disease"@en . "Omega-3 Free Fatty Acids for the Maintenance of Remission in Crohn Disease"@en . "1"^^ . "D\u00B4Haens, G." . . "McDonald, J.W.D." . . . "13"^^ . "Feagan, B. G." . . "Bar-Meir, S." . . "JAMA" . "V" . "Sandborn, W. J." . . . "Bradette, M." .