. "2" . "RIV/00843989:_____/07:00015024!RIV09-MZ0-00843989" . "SK - Slovensk\u00E1 republika" . . "Neoplasma" . "[8DCE278D2C0D]" . "Dvo\u0159\u00E1\u010Dkov\u00E1, Jana" . "Molecularly Genetic Determination of Prognostic Factors of the Prostate Cancer and Their Relationships to Expression of Protein p27kip1"@en . . "Uv\u00EDrov\u00E1, M." . . . "Vztah exprese p27kip1 k v\u00FDskytu genetick\u00FDch abnormit u negeneralizovan\u00E9ho karcinomu prostaty"@cs . "V publikovan\u00FDch studi\u00EDch, t\u00FDkaj\u00EDc\u00EDch se karcinomu prostaty, se uv\u00E1d\u00ED, \u017Ee amplifikace genu c-myc je pevn\u011B spojena s imunohistochemickou overexpres\u00ED proteinu Myc. Existuje p\u0159edpoklad, \u017Ee nadm\u011Brn\u00E1 exprese proteinu Myc zp\u016Fsobuje degradaci proteinu p27 vedouc\u00ED k aktivaci dr\u00E1hy cyklin E/cyclin-dependentn\u00ED kin\u00E1zy 2 a bun\u011B\u010Dn\u00E9 proliferaci. Jeliko\u017E je prok\u00E1z\u00E1no , \u017Ee s progres\u00ED karcinomu prostaty je spojeno mnoho chromozom\u00E1ln\u00EDch a genetick\u00FDch abnormalit, bylo c\u00EDlem na\u0161\u00ED studie prok\u00E1zat, zda existuje vztah exprese proteinu p27 k t\u011Bmto genetick\u00FDm abnormit\u00E1m.Proto\u017Ee nej\u010Dast\u011Bji posti\u017Een\u00FDm chromozomem u karcinomu prostaty je chromozom 8 a nej\u010Dast\u011Bj\u0161\u00EDmi chromozom\u00E1ln\u00EDmi zm\u011Bnami jsou delece 8p22 a amplifikace oblasti 8q24, byly hodnoceny pr\u00E1v\u011B tyto zm\u011Bny. Na\u0161e \u00FDsledky jsou pln\u011B v souladu s liter\u00E1rn\u00EDmi \u00FAdaji. Degradace proteinu p27 p\u0159edstavovan\u00E1 expres\u00ED 0-25% p\u0159evl\u00E1d\u00E1 u skupiny karcinom\u016F s n\u00E1lezem chromozom\u00E1ln\u00EDch zm\u011Bn. U karcinom\u016F s amplifikac\u00ED genu c-myc je n\u00E1lez v\u00FDrazn\u011B sn\u00ED\u017Een\u00E9 exprese proteinu p"@cs . . "Molecularly Genetic Determination of Prognostic Factors of the Prostate Cancer and Their Relationships to Expression of Protein p27kip1"@en . "000246073300010" . . "V" . "0028-2685" . "Vztah exprese p27kip1 k v\u00FDskytu genetick\u00FDch abnormit u negeneralizovan\u00E9ho karcinomu prostaty"@cs . . "RIV/00843989:_____/07:00015024" . . "407958" . "Molecularly Genetic Determination of Prognostic Factors of the Prostate Cancer and Their Relationships to Expression of Protein p27kip1" . . . . . "54" . "6"^^ . . "Published studies on prostate carcinoma report a strong connection between the c-myc gene amplification and immunohistochemical overexpression of the Myc protein.It is assumed that excessive Myc protein expression causes degradation of protein p27 resulting in activationof the pathway of cyclin E/cyclin-dependent kinase 2 and cell proliferation.Since it is known that numerous chromosomal and genetic abnormalities are connected to prostate carcinoma progression, the aim of the study was to show whether anyrelation exists between protein p27 expression and various genetic abnormities. Given that in prostate carcinoma, chromosome 8 is most usually affected, deletions 8p22and amplifications of zone 8q24 being the most frequent chromosomal changes, these were the most appropriate ones for evaluation. Our findings are in complete accord with the literature. Degradation of protein p27 represented by expression in 0-25 % prevailed in a group of prostate cancers with a finding of chromosomal ch" . . "Published studies on prostate carcinoma report a strong connection between the c-myc gene amplification and immunohistochemical overexpression of the Myc protein.It is assumed that excessive Myc protein expression causes degradation of protein p27 resulting in activationof the pathway of cyclin E/cyclin-dependent kinase 2 and cell proliferation.Since it is known that numerous chromosomal and genetic abnormalities are connected to prostate carcinoma progression, the aim of the study was to show whether anyrelation exists between protein p27 expression and various genetic abnormities. Given that in prostate carcinoma, chromosome 8 is most usually affected, deletions 8p22and amplifications of zone 8q24 being the most frequent chromosomal changes, these were the most appropriate ones for evaluation. Our findings are in complete accord with the literature. Degradation of protein p27 represented by expression in 0-25 % prevailed in a group of prostate cancers with a finding of chromosomal ch"@en . "8p22 loss; 8q24 amplification; prostate cancer; Gleason\u00B4s score; p27Kipl; prognosis"@en . "1"^^ . . . "Molecularly Genetic Determination of Prognostic Factors of the Prostate Cancer and Their Relationships to Expression of Protein p27kip1" . "2"^^ .