"[D9C5485EC894]" . "V, Z(MSM6198959216)" . "1"^^ . . . "Kol\u00E1\u0159, Z." . . . . "RIV/00843989:_____/06:00100072" . . . "\u010Cesko-slovensk\u00E1 patologie" . "prostate carcinoma; androgen receptor; Ki67; PCNA; Bax; Bcl-2; p53; p21waf1; p27kip1; carcinogenesis; hormone sensitivity"@en . "Prolifera\u010Dn\u00ED a apoptotick\u00E9 znaky u karcinomu prostaty ve vztahu k androgenov\u00E9mu receptoru"@cs . "Nedb\u00E1lek, A." . "\u0160t\u011Brba, J." . "Dvo\u0159\u00E1\u010Dkov\u00E1, Jana" . . "5"^^ . . "5"^^ . "Karcinom prostaty, jedna z nej\u010Dast\u011Bj\u0161\u00EDch malignit u mu\u017E\u016F, je v ur\u010Dit\u00FDch f\u00E1z\u00EDch sv\u00E9ho v\u00FDvoje v\u00FDznamn\u011B ovliv\u0148ov\u00E1n androgeny. Proto byla provedena na souboru 130 pacient\u016F s negeneralizovan\u00FDm (lokalizovan\u00FDm) karcinomem prostaty (stadium T1-T2 , PSA do 25 ng/ml) retrospektivn\u00ED studie. Imunohistochemicky byla stanovena exprese prolifera\u010Dn\u00EDch znak\u016F PCNA a Ki67, protein\u016F Bax, p53, Bcl-2, p21waf1, p27kip1 (d\u00E1le je p21 a p27) a bylo provedeno jejich srovn\u00E1n\u00ED s expres\u00ED androgenov\u00E9ho receptoru (AR). Multivaria\u010Dn\u00ED statistick\u00E1 anal\u00FDza v\u00FDsledk\u016F pomoc\u00ED ch\u00ED-kvadr\u00E1t testu s Pearsonovou korekc\u00ED a anal\u00FDza variability s pou\u017Eit\u00EDm programu SPSS, verze 8,0, uk\u00E1zala silnou korelaci prolifera\u010Dn\u00EDch znak\u016F PCNA a Ki67 s expres\u00ED znak\u016F hormon\u00E1ln\u00ED z\u00E1vislosti a apopt\u00F3zy. Exprese PCNA korelovala siln\u011B s expres\u00ED p27 a Bax, zat\u00EDmco exprese Ki67 korelovala nejsiln\u011Bji s expres\u00ED p27 a Bcl-2. Exprese p27 korelovala s expres\u00ED androgenov\u00E9ho receptoru, PCNA, Ki67 i Bcl-2. \u017D\u00E1dn\u00FD ze sledovan\u00FDch znak\u016F nekoreloval v\u00FDznamn\u011B s Gleaso"@cs . "Proliferative and Apoptotic Markers in Prostate Carcinoma in Relation to Androgen Receptor"@en . "CZ - \u010Cesk\u00E1 republika" . . . "495485" . . "1210-7875" . . "Proliferative and Apoptotic Markers in Prostate Carcinoma in Relation to Androgen Receptor"@en . . "\u010Ceganov\u00E1, L." . "Prolifera\u010Dn\u00ED a apoptotick\u00E9 znaky u karcinomu prostaty ve vztahu k androgenov\u00E9mu receptoru"@cs . "42" . "Prolifera\u010Dn\u00ED a apoptotick\u00E9 znaky u karcinomu prostaty ve vztahu k androgenov\u00E9mu receptoru" . . . "RIV/00843989:_____/06:00100072!RIV09-MZ0-00843989" . . "3" . . . . . "Karcinom prostaty, jedna z nej\u010Dast\u011Bj\u0161\u00EDch malignit u mu\u017E\u016F, je v ur\u010Dit\u00FDch f\u00E1z\u00EDch sv\u00E9ho v\u00FDvoje v\u00FDznamn\u011B ovliv\u0148ov\u00E1n androgeny. Proto byla provedena na souboru 130 pacient\u016F s negeneralizovan\u00FDm (lokalizovan\u00FDm) karcinomem prostaty (stadium T1-T2 , PSA do 25 ng/ml) retrospektivn\u00ED studie. Imunohistochemicky byla stanovena exprese prolifera\u010Dn\u00EDch znak\u016F PCNA a Ki67, protein\u016F Bax, p53, Bcl-2, p21waf1, p27kip1 (d\u00E1le je p21 a p27) a bylo provedeno jejich srovn\u00E1n\u00ED s expres\u00ED androgenov\u00E9ho receptoru (AR). Multivaria\u010Dn\u00ED statistick\u00E1 anal\u00FDza v\u00FDsledk\u016F pomoc\u00ED ch\u00ED-kvadr\u00E1t testu s Pearsonovou korekc\u00ED a anal\u00FDza variability s pou\u017Eit\u00EDm programu SPSS, verze 8,0, uk\u00E1zala silnou korelaci prolifera\u010Dn\u00EDch znak\u016F PCNA a Ki67 s expres\u00ED znak\u016F hormon\u00E1ln\u00ED z\u00E1vislosti a apopt\u00F3zy. Exprese PCNA korelovala siln\u011B s expres\u00ED p27 a Bax, zat\u00EDmco exprese Ki67 korelovala nejsiln\u011Bji s expres\u00ED p27 a Bcl-2. Exprese p27 korelovala s expres\u00ED androgenov\u00E9ho receptoru, PCNA, Ki67 i Bcl-2. \u017D\u00E1dn\u00FD ze sledovan\u00FDch znak\u016F nekoreloval v\u00FDznamn\u011B s Gleaso" . "Prolifera\u010Dn\u00ED a apoptotick\u00E9 znaky u karcinomu prostaty ve vztahu k androgenov\u00E9mu receptoru" . "Prostate carcinoma, one of the most frequent male malignancies, is in certain stages of its development significantly influenced by androgens. Therefore, we carried out a retrospective study on a set of 130 patients with nongeneralized, localized prostate carcinoma (stage T1-T2, PSA up to 25 ng/ml). We determined immunohistochemically the expression of proliferation markers PCNA and Ki67, Bax, p53, Bcl-2, p21waf1, p27kip1 and compared them with the expression of the androgen receptor (AR). Multivariation statistical analysis of the results using the chi-square test with Pearson\u2019s correction and variability analysis using the SPSS 8.0 software program showed a strong correlation of the PCNA and Ki67 proliferation markers with the expression of hormonal dependence and apoptosis markers. The expression of PCNA correlated strongly with p27kip1 and Bax, while the expression of Ki67 correlated most strongly with p27kip1 and Bcl-2. The expression of p27kip1 correlated with the expression of a"@en . . . .