"Ztr\u00E1ta \u010D\u00E1sti chromosomu 8p22 a amplifikace oblasti 8q24 (oblast onkogenu c-myc) jsou nej\u010Dast\u011Bj\u0161\u00ED chromosom\u00E1ln\u00ED aberace pozorovan\u00E9 u karcinomu prostaty. C\u00EDlem bylo prok\u00E1zat \u010Dastost t\u011Bchto chromosom\u00E1ln\u00EDch abnormalit a posoudit jejich souvislost s progn\u00F3zou pacient\u016F s karcinomem prostaty. Ze sledovan\u00E9ho souboru 130 pacient\u016F byla vybr\u00E1na skupina 17 pacient\u016F, kte\u0159\u00ED zem\u0159eli do p\u011Bti let po stanoven\u00ED diagn\u00F3zy. Pro nedostatek n\u00E1dorov\u00FDch bun\u011Bk v punk\u010Dn\u00EDch biopsi\u00EDch se poda\u0159ilo uskute\u010Dnit hybridizaci in situ a objektivn\u011B posoudit v\u00FDsledek u 9 pacient\u016F. V 7 p\u0159\u00EDpadech byla nalezena amplifikace oblasti pro onkogen c-myc, av\u0161ak u 5 z nich byla prok\u00E1z\u00E1na z\u00E1rove\u0148 polyploidie chromosomu 8. Delece \u010D\u00E1sti chromosomu 8p22 (oblasti pro gen LPL) byla nalezena u 5 p\u0159\u00EDpad\u016F. Norm\u00E1ln\u00ED n\u00E1lez byl prok\u00E1z\u00E1n u 2 p\u0159\u00EDpad\u016F. P\u0159i anal\u00FDze v\u0161ak nebylo mo\u017Eno dodr\u017Eet liter\u00E1rn\u011B po\u017Eadovan\u00FD po\u010Det 300 vy\u0161et\u0159en\u00FDch nep\u0159ekr\u00FDvaj\u00EDc\u00EDch se n\u00E1dorov\u00FDch bun\u011Bk vzhledem ke kvalit\u011B arch\u00EDvn\u00EDho bioptick\u00E9ho materi\u00E1lu. Doporu\u010Dujeme proto v\u017Edy zv\u00E1\u017E"@cs . . "Problematika molekul\u00E1rn\u011B genetick\u00E9ho stanoven\u00ED prognostick\u00FDch faktor\u016F u karcinomu prostaty: pilotn\u00ED studie" . "Uv\u00EDrov\u00E1, M." . . "Dvo\u0159\u00E1\u010Dkov\u00E1, Jana" . "Ztr\u00E1ta \u010D\u00E1sti chromosomu 8p22 a amplifikace oblasti 8q24 (oblast onkogenu c-myc) jsou nej\u010Dast\u011Bj\u0161\u00ED chromosom\u00E1ln\u00ED aberace pozorovan\u00E9 u karcinomu prostaty. C\u00EDlem bylo prok\u00E1zat \u010Dastost t\u011Bchto chromosom\u00E1ln\u00EDch abnormalit a posoudit jejich souvislost s progn\u00F3zou pacient\u016F s karcinomem prostaty. Ze sledovan\u00E9ho souboru 130 pacient\u016F byla vybr\u00E1na skupina 17 pacient\u016F, kte\u0159\u00ED zem\u0159eli do p\u011Bti let po stanoven\u00ED diagn\u00F3zy. Pro nedostatek n\u00E1dorov\u00FDch bun\u011Bk v punk\u010Dn\u00EDch biopsi\u00EDch se poda\u0159ilo uskute\u010Dnit hybridizaci in situ a objektivn\u011B posoudit v\u00FDsledek u 9 pacient\u016F. V 7 p\u0159\u00EDpadech byla nalezena amplifikace oblasti pro onkogen c-myc, av\u0161ak u 5 z nich byla prok\u00E1z\u00E1na z\u00E1rove\u0148 polyploidie chromosomu 8. Delece \u010D\u00E1sti chromosomu 8p22 (oblasti pro gen LPL) byla nalezena u 5 p\u0159\u00EDpad\u016F. Norm\u00E1ln\u00ED n\u00E1lez byl prok\u00E1z\u00E1n u 2 p\u0159\u00EDpad\u016F. P\u0159i anal\u00FDze v\u0161ak nebylo mo\u017Eno dodr\u017Eet liter\u00E1rn\u011B po\u017Eadovan\u00FD po\u010Det 300 vy\u0161et\u0159en\u00FDch nep\u0159ekr\u00FDvaj\u00EDc\u00EDch se n\u00E1dorov\u00FDch bun\u011Bk vzhledem ke kvalit\u011B arch\u00EDvn\u00EDho bioptick\u00E9ho materi\u00E1lu. Doporu\u010Dujeme proto v\u017Edy zv\u00E1\u017E" . "1"^^ . . "RIV/00843989:_____/06:00100071!RIV09-MZ0-00843989" . "3" . "\u010Cesko-slovensk\u00E1 patologie" . "RIV/00843989:_____/06:00100071" . "3"^^ . "2"^^ . . "[0A1F67D22ACC]" . "The Molecular Genetic Assessment of Prognostic Factors in Carcioma of the Prostate: a Pilot Study"@en . . . . . "The loss of the 8p22 chromosome part and amplification of the 8q24 region (c-myc oncogene region) are the most frequent chromosomal aberrations observed in prostate carcinoma. We aimed to demonstrate the frequency of these chromosomal abnormalities and to assess how they correlate with the prognosis in patients with prostate carcinoma. From a set of 130 patients, we selected a group of 17 who died within five years after the diagnosis had been determined. Due to the lack of tumor cells in puncture biopsies, we managed to carry out in situ hybridization and assess the result objectively for 9 patients only. In seven cases, amplification of the region for c-myc oncogene was found; however, in five of them, polyploidy of chromosome 8 was manifested simultaneously. Deletion of the 8p22 chromosome part (region for the LPL gene) was found in five cases. A normal finding was detected in two cases. However, the analysis was carried out on a small number of cells gained from paraffin slices, so"@en . . . . "1210-7875" . . "Problematika molekul\u00E1rn\u011B genetick\u00E9ho stanoven\u00ED prognostick\u00FDch faktor\u016F u karcinomu prostaty: pilotn\u00ED studie" . . "Problematika molekul\u00E1rn\u011B genetick\u00E9ho stanoven\u00ED prognostick\u00FDch faktor\u016F u karcinomu prostaty: pilotn\u00ED studie"@cs . "The Molecular Genetic Assessment of Prognostic Factors in Carcioma of the Prostate: a Pilot Study"@en . . "Problematika molekul\u00E1rn\u011B genetick\u00E9ho stanoven\u00ED prognostick\u00FDch faktor\u016F u karcinomu prostaty: pilotn\u00ED studie"@cs . "loss of the 8p22 chromosome part; amplification of the 8q24 region; prostate carcinoma; prognosis"@en . "42" . "CZ - \u010Cesk\u00E1 republika" . "V" . "494945" . .