"2"^^ . . . . "0862-495X" . "476885" . . "Genetic susceptibility to breast cancer"@en . "[0BD0D9A92ED9]" . "Breast cancer is the most frequent malignancy diagnosed in women in the western world, affecting approximately 1 in 10 women. Estimated 5-7% of all breast cancers can be of hereditary origin. Familial cases of the breast cancer are characterised by relatively young age at diagnoses, an increased risk of bilateral breast cancer, and a strong association with ovarian cancer. Inherited mutations in BRCA1 and BRCA2 are the major reason for the genetic predisposition to these cancers. Here, we summarised what is known about the genetic susceptibility to breast and ovarian cancers, biological functions of the BRCA1 and BRCA2 genes, histopathological features, specificpreventive and therapeutic intervention of the cancers in mutation carriers."@en . "6"^^ . "Genetick\u00E1 predispozice ke vzniku malign\u00EDho n\u00E1doru prsu"@cs . "Suppl." . . "Foretov\u00E1, L." . . "7"^^ . "Klinick\u00E1 onkologie" . "CZ - \u010Cesk\u00E1 republika" . "\u0160ilh\u00E1nov\u00E1, Eva" . "Va\u0161\u00ED\u010Dkov\u00E1, P." . . "19" . . . "BRCA1; BRCA2; genetic susceptibility; breast cancer; ovarian cancer"@en . . "RIV/00843989:_____/06:00100065!RIV09-MSM-00843989" . "Luke\u0161ov\u00E1, M." . "Genetick\u00E1 predispozice ke vzniku malign\u00EDho n\u00E1doru prsu" . "Genetick\u00E1 predispozice ke vzniku malign\u00EDho n\u00E1doru prsu" . . . . "Genetick\u00E1 predispozice ke vzniku malign\u00EDho n\u00E1doru prsu"@cs . . "RIV/00843989:_____/06:00100065" . . . "P(NR8022), P(NR8213), Z(MSM6198959216), Z(MZ00020980501), Z(MZ0MOU2005)" . "N\u00E1dor prsu je jedn\u00EDm z nej\u010Dast\u011Bji diagnostikovan\u00FDch malign\u00EDch onemocn\u011Bn\u00ED u \u017Een z\u00E1padn\u00EDho sv\u011Bta, kde je t\u00EDmto onemocn\u011Bn\u00EDm posti\u017Eena ka\u017Ed\u00E1 des\u00E1t\u00E1 \u017Eena. P\u0159ibli\u017En\u011B 5-7% n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED prsu vznik\u00E1 na z\u00E1klad\u011B genetick\u00E9 predispozice. D\u011Bdi\u010Dn\u00E9 p\u0159\u00EDpady n\u00E1doru prsu b\u00FDvaj\u00ED diagnostikov\u00E1ny v relativn\u011B mlad\u00E9m v\u011Bku, p\u0159i\u010Dem\u017E u posti\u017Een\u00FDch \u017Een je vysok\u00E9 riziko vzniku duplexn\u00EDho n\u00E1doru prsu nebo ovaria. Hlavn\u00ED p\u0159\u00ED\u010Dinou genetick\u00E9 predispozice ke vzniku n\u00E1doru prsu a ovaria jsou mutace v genech BRCA1 a BRCA2. V tomto p\u0159ehledov\u00E9m \u010Dl\u00E1nku se pokus\u00EDme podat aktu\u00E1ln\u00ED p\u0159ehled o p\u0159\u00ED\u010Din\u00E1ch genetick\u00E9 predispozici ke vzniku n\u00E1doru prsu a ovaria, o biologick\u00E9 funkci gen\u016F BRCA1 a BRCA2, histopatologick\u00E9 charakteristice a mo\u017En\u00FDch specifick\u00FDch aspektech prevence a l\u00E9\u010Dby u nosi\u010D\u016F z\u00E1rode\u010Dn\u00E9 mutace"@cs . . "N\u00E1dor prsu je jedn\u00EDm z nej\u010Dast\u011Bji diagnostikovan\u00FDch malign\u00EDch onemocn\u011Bn\u00ED u \u017Een z\u00E1padn\u00EDho sv\u011Bta, kde je t\u00EDmto onemocn\u011Bn\u00EDm posti\u017Eena ka\u017Ed\u00E1 des\u00E1t\u00E1 \u017Eena. P\u0159ibli\u017En\u011B 5-7% n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED prsu vznik\u00E1 na z\u00E1klad\u011B genetick\u00E9 predispozice. D\u011Bdi\u010Dn\u00E9 p\u0159\u00EDpady n\u00E1doru prsu b\u00FDvaj\u00ED diagnostikov\u00E1ny v relativn\u011B mlad\u00E9m v\u011Bku, p\u0159i\u010Dem\u017E u posti\u017Een\u00FDch \u017Een je vysok\u00E9 riziko vzniku duplexn\u00EDho n\u00E1doru prsu nebo ovaria. Hlavn\u00ED p\u0159\u00ED\u010Dinou genetick\u00E9 predispozice ke vzniku n\u00E1doru prsu a ovaria jsou mutace v genech BRCA1 a BRCA2. V tomto p\u0159ehledov\u00E9m \u010Dl\u00E1nku se pokus\u00EDme podat aktu\u00E1ln\u00ED p\u0159ehled o p\u0159\u00ED\u010Din\u00E1ch genetick\u00E9 predispozici ke vzniku n\u00E1doru prsu a ovaria, o biologick\u00E9 funkci gen\u016F BRCA1 a BRCA2, histopatologick\u00E9 charakteristice a mo\u017En\u00FDch specifick\u00FDch aspektech prevence a l\u00E9\u010Dby u nosi\u010D\u016F z\u00E1rode\u010Dn\u00E9 mutace" . "Genetic susceptibility to breast cancer"@en . "Plevov\u00E1, Pavl\u00EDna" . . . . "Mach\u00E1\u010Dkov\u00E1, E." . . . .