. "Neuropatie a hepatitida C"@cs . "RIV/00669806:_____/13:10139910" . "Ambler, Zden\u011Bk" . . "1213-1814" . "Neurologie pro praxi" . "14" . . "Neuropatie a hepatitida C" . . . . . "Peripheral neuropathy and hepatitis C"@en . "3" . . "1"^^ . "CZ - \u010Cesk\u00E1 republika" . "hepatitis; neuropathy; Peripheral"@en . . "[8758A3CD244E]" . "1"^^ . . "Neuropatie a hepatitida C"@cs . "Peripheral neuropathy and hepatitis C"@en . "91470" . . "4"^^ . . "Infekce virem hepatitidy C (HCV) b\u00FDv\u00E1 spojena s extrahepat\u00E1ln\u00EDmi projevy a\u017E u 36 % nemocn\u00FDch, hlavn\u011B s kryoglobulinemi\u00ED, trombopenickou purpurou a membranoproliferativn\u00ED glomerulonefritidou. Sm\u00ED\u0161en\u00E1 kryoglobulinemie je charakterizov\u00E1na typickou klinickou trias (purpura, slabost, artralgie) a posti\u017Een\u00EDm jednoho nebo v\u00EDce org\u00E1n\u016F nebo syst\u00E9m\u016F (j\u00E1tra, ledviny a perifern\u00ED nervy). Perifern\u00ED neuropatie m\u016F\u017Ee b\u00FDt tak\u00E9 asociov\u00E1na s HCV infekc\u00ED a obvykle souvis\u00ED se sm\u00ED\u0161enou kryoglobulinemi\u00ED, ale byly pops\u00E1ny i neuropatie bez p\u0159\u00EDtomnosti s\u00E9rov\u00FDch kryoglobulin\u016F. HCV-asociovan\u00E1 neuropatie je obvykle axon\u00E1ln\u00ED, typu chronick\u00E9 symetrick\u00E9 senzitivn\u00ED nebo senzitivn\u011B-motorick\u00E9 polyneuropatie nebo subakutn\u00ED mononeuropatie multiplex v d\u016Fsledku vaskulitidy. L\u00E9\u010Dba pegylovan\u00FDm interferonem-alfa a ribavirinem je v\u011Bt\u0161inou spojena se zlep\u0161en\u00EDm jatern\u00EDch parametr\u016F a vaskulitick\u00FDch p\u0159\u00EDznak\u016F. V n\u011Bkter\u00FDch p\u0159\u00EDpadech bylo ale pozorov\u00E1no zhor\u0161en\u00ED nebo i nov\u00E1 manifestace perifern\u00ED neuropatie. Tito pacienti se mohou zlep\u0161it po rituximabu, kter\u00FD p\u0159edstavuje alternativn\u00ED l\u00E9\u010Dbu." . "Neuropatie a hepatitida C" . "Infekce virem hepatitidy C (HCV) b\u00FDv\u00E1 spojena s extrahepat\u00E1ln\u00EDmi projevy a\u017E u 36 % nemocn\u00FDch, hlavn\u011B s kryoglobulinemi\u00ED, trombopenickou purpurou a membranoproliferativn\u00ED glomerulonefritidou. Sm\u00ED\u0161en\u00E1 kryoglobulinemie je charakterizov\u00E1na typickou klinickou trias (purpura, slabost, artralgie) a posti\u017Een\u00EDm jednoho nebo v\u00EDce org\u00E1n\u016F nebo syst\u00E9m\u016F (j\u00E1tra, ledviny a perifern\u00ED nervy). Perifern\u00ED neuropatie m\u016F\u017Ee b\u00FDt tak\u00E9 asociov\u00E1na s HCV infekc\u00ED a obvykle souvis\u00ED se sm\u00ED\u0161enou kryoglobulinemi\u00ED, ale byly pops\u00E1ny i neuropatie bez p\u0159\u00EDtomnosti s\u00E9rov\u00FDch kryoglobulin\u016F. HCV-asociovan\u00E1 neuropatie je obvykle axon\u00E1ln\u00ED, typu chronick\u00E9 symetrick\u00E9 senzitivn\u00ED nebo senzitivn\u011B-motorick\u00E9 polyneuropatie nebo subakutn\u00ED mononeuropatie multiplex v d\u016Fsledku vaskulitidy. L\u00E9\u010Dba pegylovan\u00FDm interferonem-alfa a ribavirinem je v\u011Bt\u0161inou spojena se zlep\u0161en\u00EDm jatern\u00EDch parametr\u016F a vaskulitick\u00FDch p\u0159\u00EDznak\u016F. V n\u011Bkter\u00FDch p\u0159\u00EDpadech bylo ale pozorov\u00E1no zhor\u0161en\u00ED nebo i nov\u00E1 manifestace perifern\u00ED neuropatie. Tito pacienti se mohou zlep\u0161it po rituximabu, kter\u00FD p\u0159edstavuje alternativn\u00ED l\u00E9\u010Dbu."@cs . "RIV/00669806:_____/13:10139910!RIV14-MZ0-00669806" . . . "http://www.neurologiepropraxi.cz/artkey/neu-201303-0009_Neuropatie_a_hepatitida_C.php" . "I" . . "Infection with the hepatitis C virus (HCV) can be associated with extrahepatic manifestations in as much as 36% of HCV patients, mainly with cryoglobulinemia, thrombopenic purpura, and membranoproliferative glomerulonephritis. The mixed cryoglobulinemia is characterized by a typical clinical triad (purpura, weakness, arthralgias) and by involvement of one or more organs or systems (liver, kidney, and peripheral nerve). Peripheral neuropathy may also be associated with HCV infection and it is usually related to mixed cryoglobulinaemia but neuropathies in the absence of serum cryoglobulins have also been described. HCV-associated neuropathy is usually an axonal-type chronic symmetrical sensory or sensorimotor polyneuropathy or a subacute mononeuropathy multiplex due to vasculitis. Treatment with pegylated interferon-alfa and ribavirin mostly is associated with an improvement of hepatic parameters and vasculitic symptoms. In some cases, worsening or even new onset of peripheral neuropathy was observed. These patients can improve with rituximab that represent an alternative treatment."@en .