"4"^^ . "Pou\u017Eit\u00ED bosentanu v l\u00E9\u010Db\u011B vaskul\u00E1rn\u00EDch komplikac\u00ED syst\u00E9mov\u00E9 sklerodermie"@cs . "RIV/00669806:_____/12:10139619!RIV14-MZ0-00669806" . "Systemic Sclerosis (SSc) is a disease of unknown etiology characterized by vasculopathy, fibrosis and autoimmune processes. Digital ischemia presented as Raynaud\u015B phenomenon (RP) or digital ulcers (DUs) is the hallmark of SSc-related vasculopathy. DU are frequent and are associated with significant morbidity. This paper briefly summarizes the current approach to the treatment of DUs and in addition case report of young female suffering with secondary RP with DUs, treated with bosentan."@en . . "[E00EDF91AE21]" . "Hrom\u00E1dka, Milan" . "Syst\u00E9mov\u00E1 sklerodermie (SSc) je autoimunitn\u00ED onemocn\u011Bn\u00ED nejasn\u00E9 etiologie charakterizovan\u00E9 vaskulopati\u00ED a fibr\u00F3zou. Jedn\u00EDm z projev\u016F vaskulopatie spojen\u00E9 s SSc je Raynaud\u016Fv fenom\u00E9n (RF) nebo digit\u00E1ln\u00ED ulcerace(DU). Digit\u00E1ln\u00ED ulcerace jsou \u010Dastou komplikac\u00ED spojenou s signifikantn\u00ED morbiditou. Tato pr\u00E1ce stru\u010Dn\u011B sumarizuje sou\u010Dasn\u00FD p\u0159\u00EDstup v l\u00E9\u010Db\u011B DU a nav\u00EDc prezentuje kazuistiku mlad\u00E9 pacientky se sekund\u00E1rn\u00EDm RF a DU, l\u00E9\u010Den\u00E9 bosentanem.|" . "RIV/00669806:_____/12:10139619" . . . . . "Syst\u00E9mov\u00E1 sklerodermie (SSc) je autoimunitn\u00ED onemocn\u011Bn\u00ED nejasn\u00E9 etiologie charakterizovan\u00E9 vaskulopati\u00ED a fibr\u00F3zou. Jedn\u00EDm z projev\u016F vaskulopatie spojen\u00E9 s SSc je Raynaud\u016Fv fenom\u00E9n (RF) nebo digit\u00E1ln\u00ED ulcerace(DU). Digit\u00E1ln\u00ED ulcerace jsou \u010Dastou komplikac\u00ED spojenou s signifikantn\u00ED morbiditou. Tato pr\u00E1ce stru\u010Dn\u011B sumarizuje sou\u010Dasn\u00FD p\u0159\u00EDstup v l\u00E9\u010Db\u011B DU a nav\u00EDc prezentuje kazuistiku mlad\u00E9 pacientky se sekund\u00E1rn\u00EDm RF a DU, l\u00E9\u010Den\u00E9 bosentanem.|"@cs . . . "1212-7973" . . "Pou\u017Eit\u00ED bosentanu v l\u00E9\u010Db\u011B vaskul\u00E1rn\u00EDch komplikac\u00ED syst\u00E9mov\u00E9 sklerodermie" . . . "26" . "Klinick\u00E1 farmakologie a farmacie" . . "I" . . "Pou\u017Eit\u00ED bosentanu v l\u00E9\u010Db\u011B vaskul\u00E1rn\u00EDch komplikac\u00ED syst\u00E9mov\u00E9 sklerodermie"@cs . "3"^^ . "bosentan; treatment; digital ulcers; Raynauds phenomenon; systemic sclerosis"@en . "Such\u00FD, David" . . . "3"^^ . "CZ - \u010Cesk\u00E1 republika" . "Bosentan in treating vascular complications of systemic sclerosis"@en . . . . . "160410" . "Pou\u017Eit\u00ED bosentanu v l\u00E9\u010Db\u011B vaskul\u00E1rn\u00EDch komplikac\u00ED syst\u00E9mov\u00E9 sklerodermie" . "4" . . "Jeremi\u00E1\u0161, Pavel" . "Bosentan in treating vascular complications of systemic sclerosis"@en .