. "Oral cavity cooling (cryotherapy) provided during high-dose melphalan bolus or short-infusion administration contributes to local vasoconstriction, lower blood circulation, lower local cytotoxic drug exposure and significantly reduced oral mucositis (OM) incidence.1-3 OM is a significant posttransplant complication, and together with gut tissue damage and inflammation, caused by conditioning regimens, contributes to the development and pathogenesis of acute GVHD.4-6 The incidence of acute GVHD varies between 28 and 45% in the Flu/Mel-reduced intensity conditioning regimen comprising of fludarabine total dose 125-150mg/m2 and melphalan total dose 140-180mg/m2.1,7-9 We decided to analyze the impact of reduced OMincidence (reduced oral tissue damage) on acute GVHD, and analyzed 142 prospectively observed patients after Flu/Mel (fludarabine 30mg/m2 i.v. once daily for 4 days, melphalan 140mg/m2 i.v. one day before transplantation) allo-SCT performed at our institution from January 2005 to December 2010." . . "5" . "47" . . "I" . . . . . "5"^^ . . "5"^^ . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . . "Oral cryotherapy can significantly reduce oral mucositis but not acute GVHD incidence in Flu/Mel conditioning allo-SCT" . . "prevention; fludarabine; regimen; melphalan; Stem-cell transplantation"@en . "0268-3369" . . "3"^^ . "Oral cryotherapy can significantly reduce oral mucositis but not acute GVHD incidence in Flu/Mel conditioning allo-SCT" . "10.1038/bmt.2011.156" . "Oral cryotherapy can significantly reduce oral mucositis but not acute GVHD incidence in Flu/Mel conditioning allo-SCT"@en . "157039" . "Svoboda, Tom\u00E1\u0161" . "Karas, Michal" . "http://www.nature.com/bmt/journal/v47/n5/pdf/bmt2011156a.pdf" . "Oral cryotherapy can significantly reduce oral mucositis but not acute GVHD incidence in Flu/Mel conditioning allo-SCT"@en . . "Oral cavity cooling (cryotherapy) provided during high-dose melphalan bolus or short-infusion administration contributes to local vasoconstriction, lower blood circulation, lower local cytotoxic drug exposure and significantly reduced oral mucositis (OM) incidence.1-3 OM is a significant posttransplant complication, and together with gut tissue damage and inflammation, caused by conditioning regimens, contributes to the development and pathogenesis of acute GVHD.4-6 The incidence of acute GVHD varies between 28 and 45% in the Flu/Mel-reduced intensity conditioning regimen comprising of fludarabine total dose 125-150mg/m2 and melphalan total dose 140-180mg/m2.1,7-9 We decided to analyze the impact of reduced OMincidence (reduced oral tissue damage) on acute GVHD, and analyzed 142 prospectively observed patients after Flu/Mel (fludarabine 30mg/m2 i.v. once daily for 4 days, melphalan 140mg/m2 i.v. one day before transplantation) allo-SCT performed at our institution from January 2005 to December 2010."@en . "RIV/00669806:_____/12:10135327!RIV14-MZ0-00669806" . . . . . "Bone Marrow Transplantation" . . . "Koza, Vladim\u00EDr" . "[D124FEE3A918]" . "000303923500021" . . . "RIV/00669806:_____/12:10135327" . "Vokurka, Samuel" . "Jungov\u00E1, Alexandra" .