. "[BC0052F4FF82]" . "Electrochemical Behaviour of Native and Denatured B-Sheet Breaker Prion Protein" . "\u0160obrov\u00E1, Pavl\u00EDna" . . . "RS - Srbsk\u00E1 republika" . . "7" . . . "INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE" . . "RIV/00216305:26620/12:PU99117" . "Hynek, David" . . . "15"^^ . . "Adam, Vojt\u011Bch" . . . . . "RIV/00216305:26620/12:PU99117!RIV13-AV0-26620___" . "Electrochemical Behaviour of Native and Denatured B-Sheet Breaker Prion Protein" . "Prion diseases are fatal neurodegenerative and infectious disorders of humans and animals, characterized by structural transition of the host-encoded cellular prion protein (PrPC) into the aberrantly folded pathologic isoform PrPSc. The conformation change, from the a-helix in the natural protein form (PrPc) to the b-sheet of the modified protein form (PrPSc), significantly influence the protein function. The mutated form (PrPSc) is extremely resistant to the cell degradation processes and may bind other PrPc molecules inducing the conformation change to the PrPSc. The insufficiency of the physiological PrPc and toxic incidence of PrPSc participate on the genesis of prion neurodegenerative diseases. The main aim of this study was to suggest electrochemical methods for detection of b-sheet breaker prion protein. For this purpose cyclic voltammetry (CV), differential pulse voltammetry (DPV), differential pulse voltammetry Brdicka reaction and chronopotentiometric stripping analysis (CPSA) were used. Pri" . . . "133855" . . . "2" . "Vaculovi\u010Dov\u00E1, Mark\u00E9ta" . . "Prion protein (PrPSc \u2013 scrapie), Adsorptive transfer stripping technique, cyclic voltammetry (CV), differential pulse voltammetry (DPV), Brdicka reaction, Chronopotenciometric stripping analysis (CPSA)"@en . . "1452-3981" . . . . "6"^^ . "Hub\u00E1lek, Jarom\u00EDr" . "6"^^ . "000302730000003" . "Kizek, Ren\u00E9" . "Electrochemical Behaviour of Native and Denatured B-Sheet Breaker Prion Protein"@en . "Electrochemical Behaviour of Native and Denatured B-Sheet Breaker Prion Protein"@en . . . "P(ED1.1.00/02.0068), P(GAP102/11/1068), P(IAA401990701), P(KAN208130801)" . . "Prion diseases are fatal neurodegenerative and infectious disorders of humans and animals, characterized by structural transition of the host-encoded cellular prion protein (PrPC) into the aberrantly folded pathologic isoform PrPSc. The conformation change, from the a-helix in the natural protein form (PrPc) to the b-sheet of the modified protein form (PrPSc), significantly influence the protein function. The mutated form (PrPSc) is extremely resistant to the cell degradation processes and may bind other PrPc molecules inducing the conformation change to the PrPSc. The insufficiency of the physiological PrPc and toxic incidence of PrPSc participate on the genesis of prion neurodegenerative diseases. The main aim of this study was to suggest electrochemical methods for detection of b-sheet breaker prion protein. For this purpose cyclic voltammetry (CV), differential pulse voltammetry (DPV), differential pulse voltammetry Brdicka reaction and chronopotentiometric stripping analysis (CPSA) were used. Pri"@en . "26620" . .