"This study is focused on the determination of 10 acidic drugs mainly from the group of non-steroidal anti-inflammatory drugs (NSAID) in wastewater and surface water. Target compounds were follows: salicylic acid, acetylsalicylic acid, clofibric acid, ibuprofen, caffeine, naproxen, mefenamic acid, ketoprofen and diclofenac. Samples of wastewater were collected daily in November 2010 from the influent and effluent of the WWTP in Brno \u2013 Mod\u0159ice in Czech Republic. Samples of surface water were collected from significant river stream Svratka in Czech Republic in October 2010. Solid phase extraction (SPE) was used for extraction and preconcentration of analytes. Comprehensive two-dimensional gas chromatography with mass spectrometric detection Time-of-Flight (GCxGC-TOF MS) was used for final analysis of these compounds as an excellent method for trace and ultra trace analysis of organic compounds, due to its high separation efficiency and sensitivity. Only disadvantage is the necessity to derivatize sele"@en . . . . "Application of GCxGC-TOF MS for the analysis of drug residues in wastewaters and surface waters"@en . "Lacina, Petr" . . . "V\u00E1vrov\u00E1, Milada" . "\u010C\u00E1slavsk\u00FD, Josef" . . . . "S" . "4"^^ . . "RIV/00216305:26310/11:PU95391!RIV12-MSM-26310___" . "Application of GCxGC-TOF MS for the analysis of drug residues in wastewaters and surface waters" . . "26310" . "GCxGC-TOF MS, SPE, derivatization, wastewater, surface water"@en . . "4"^^ . "[EB1BAD803D7A]" . . . "RIV/00216305:26310/11:PU95391" . "Application of GCxGC-TOF MS for the analysis of drug residues in wastewaters and surface waters"@en . . . . . "This study is focused on the determination of 10 acidic drugs mainly from the group of non-steroidal anti-inflammatory drugs (NSAID) in wastewater and surface water. Target compounds were follows: salicylic acid, acetylsalicylic acid, clofibric acid, ibuprofen, caffeine, naproxen, mefenamic acid, ketoprofen and diclofenac. Samples of wastewater were collected daily in November 2010 from the influent and effluent of the WWTP in Brno \u2013 Mod\u0159ice in Czech Republic. Samples of surface water were collected from significant river stream Svratka in Czech Republic in October 2010. Solid phase extraction (SPE) was used for extraction and preconcentration of analytes. Comprehensive two-dimensional gas chromatography with mass spectrometric detection Time-of-Flight (GCxGC-TOF MS) was used for final analysis of these compounds as an excellent method for trace and ultra trace analysis of organic compounds, due to its high separation efficiency and sensitivity. Only disadvantage is the necessity to derivatize sele" . . "186781" . "Mravcov\u00E1, Ludmila" . . . "Application of GCxGC-TOF MS for the analysis of drug residues in wastewaters and surface waters" .