"t-tubules, TATS, Heart, Calcium, Ventricle, Computer model"@en . . . "RIV/00216305:26220/08:PU71089!RIV10-MSM-26220___" . "Modelling the cardiac transverse-axial tubular system" . . "Modelling the cardiac transverse-axial tubular system"@en . "2008 (96)" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "2"^^ . . "1"^^ . . "26220" . . "18"^^ . . . . . . . "P\u00E1sek, Michal" . "The transverse-axial tubular system (TATS) of cardiac ventricular myocytes is a complex network of tubules that arises as invaginations of the surface membrane; it appears to form a specialised region of cell membrane that is particularly important for excitation-contraction coupling. However much remains unknown about the structure and role of the TATS. In this brief review we use experimental data and computer modelling to address the following key questions: (i) What fraction of the cell membrane is within the TATS? (ii) Is the composition of the TATS membrane the same as the surface membrane? (iii) How good is electrical coupling between the surface and TATS membranes? (iv) What fraction of each current is within the TATS? (v) How important is the complex structure of the TATS network? (vi) What is the effect of current inhomogeneity on lumenal ion concentrations? (vii) Does the TATS contribute to the functional changes observed in heart failure? Although there are many areas in which experimental" . "380001" . "PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY" . . . . "Z(AV0Z20760514), Z(MSM0021622402), Z(MSM0021630513)" . "0079-6107" . . "\u0160imurda, Ji\u0159\u00ED" . "1-3" . "RIV/00216305:26220/08:PU71089" . "The transverse-axial tubular system (TATS) of cardiac ventricular myocytes is a complex network of tubules that arises as invaginations of the surface membrane; it appears to form a specialised region of cell membrane that is particularly important for excitation-contraction coupling. However much remains unknown about the structure and role of the TATS. In this brief review we use experimental data and computer modelling to address the following key questions: (i) What fraction of the cell membrane is within the TATS? (ii) Is the composition of the TATS membrane the same as the surface membrane? (iii) How good is electrical coupling between the surface and TATS membranes? (iv) What fraction of each current is within the TATS? (v) How important is the complex structure of the TATS network? (vi) What is the effect of current inhomogeneity on lumenal ion concentrations? (vii) Does the TATS contribute to the functional changes observed in heart failure? Although there are many areas in which experimental"@en . . "[30907CF4F5C8]" . "Modelling the cardiac transverse-axial tubular system" . "Modelling the cardiac transverse-axial tubular system"@en . . . .