"Pardubice" . "RIV/00216275:25310/14:39898736" . . . . . "Modern nitramines TNAZ and CL-20 (HNIW): their electron-accepting potency, enzymatic reactivity and cytotoxicity" . . "Miliukiene, Vale" . "Environmental contamination by energetic materials is an acute problem, and nitramine compds. are one of the major groups of such type contaminants. One of the initial stages of biodegradation and/or toxic action of such compounds is frequently related to their 1e-/2e-(4e-) reduction catalyzed by redox-active flavoenzymes. The enzymic reactivity of TNAZ and CL-20 (HNIW) - was examined towards single- and two-electron transferring flavoenzymes and their electron-accepting potency was assessed by electrochem. and quantum mechanical methods. The standard nitramine RDX was also used. The found reactivity increased with an increase in the electron-accepting potency of the compds. TNAZ and CL-20 were found to be much more toxic compds. for mice splenocytes than RDX. This toxicity is much higher than that TEX and BCHMX. This work demonstrates that the cytotoxicity of the compounds is caused mainly by their electron-accepting potency and might be influenced by their structural peculiarities." . "8"^^ . "Elbeih, Ahmed Ikhlas Mohamed" . "Cenas, Narimantas" . . "Sarlauskas, Jonas" . . "New Trends in Research of Energetic Materials: proceedings of the 17th seminar" . . "Modern nitramines TNAZ and CL-20 (HNIW): their electron-accepting potency, enzymatic reactivity and cytotoxicity"@en . "Modern nitramines TNAZ and CL-20 (HNIW): their electron-accepting potency, enzymatic reactivity and cytotoxicity"@en . "2014-04-09+02:00"^^ . "Zeman, Svatopluk" . "18"^^ . . . "2"^^ . "RIV/00216275:25310/14:39898736!RIV15-MSM-25310___" . "Modern nitramines TNAZ and CL-20 (HNIW): their electron-accepting potency, enzymatic reactivity and cytotoxicity" . . . . "enzymatic reactions; flavoenzymes; cytotoxicity; toxicity; quantum mechanical calculation; peak potential; RDX; HNIW; CL-20; TNAZ; nitro group; caged nitramines; strained cyclic nitramines; high energy materials"@en . . "[BFFD9497DB24]" . . . . . "I" . "Elbeih, Ahmed Ikhlas Mohamed" . "30041" . "Anusevicius, Zilvinas" . . . . . . . "25310" . "978-80-7395-770-4" . "Univerzita Pardubice" . "Miseviciene, Lina" . "Miseviciene, Kastis" . . "Environmental contamination by energetic materials is an acute problem, and nitramine compds. are one of the major groups of such type contaminants. One of the initial stages of biodegradation and/or toxic action of such compounds is frequently related to their 1e-/2e-(4e-) reduction catalyzed by redox-active flavoenzymes. The enzymic reactivity of TNAZ and CL-20 (HNIW) - was examined towards single- and two-electron transferring flavoenzymes and their electron-accepting potency was assessed by electrochem. and quantum mechanical methods. The standard nitramine RDX was also used. The found reactivity increased with an increase in the electron-accepting potency of the compds. TNAZ and CL-20 were found to be much more toxic compds. for mice splenocytes than RDX. This toxicity is much higher than that TEX and BCHMX. This work demonstrates that the cytotoxicity of the compounds is caused mainly by their electron-accepting potency and might be influenced by their structural peculiarities."@en . "Pardubice" . .