"80218" . "Inhibitory effect of carbamates in two types of cholinesterases" . . "2"^^ . . . "Inhibitory effect of carbamates in two types of cholinesterases" . "CZ - \u010Cesk\u00E1 republika" . "RIV/00216275:25310/13:39896738!RIV14-MSM-25310___" . . . "RIV/00216275:25310/13:39896738" . . "prosinec" . "Inhibitory effect of carbamates in two types of cholinesterases"@en . . "cholinesterases, inhibition, carbamates"@en . "19" . . "I, S" . "Inhibitory effect of substituted 3-(diethylaminophenyl) phenyl carbamates in two types of cholineserases (acetylcholinesterase and butyrylcholinesterase) was determined. Inhibiting effectiveness was described by the value of IC50 (50% inhibitory concentration). Modified spectrophotometric Ellman's method was used. Two types of choline esters were used as substrates for cholinesterases. It was proved, that chosen carbamates are quite effective inhibitors of cholinesterases. The most effective inhibitor of acetylcholinesterase is 3-(diethylaminophenyl) phenyl carbamate with the value of IC50 = 1.52 uM and the most effective inhibitor of butyrylcholinesterase is 3-(diethylaminophenyl) (3-nitrophenyl) carbamate with the value of IC50 = 1.70 uM."@en . "\u0160t\u011Bp\u00E1nkov\u00E1, \u0160\u00E1rka" . "25310" . "1211-5541" . "Vor\u010D\u00E1kov\u00E1, Katar\u00EDna" . . . . "Scientific Papers of the University of Pardubice, Series A, Faculty of Chemical Technology" . "Inhibitory effect of carbamates in two types of cholinesterases"@en . . . . . "Inhibitory effect of substituted 3-(diethylaminophenyl) phenyl carbamates in two types of cholineserases (acetylcholinesterase and butyrylcholinesterase) was determined. Inhibiting effectiveness was described by the value of IC50 (50% inhibitory concentration). Modified spectrophotometric Ellman's method was used. Two types of choline esters were used as substrates for cholinesterases. It was proved, that chosen carbamates are quite effective inhibitors of cholinesterases. The most effective inhibitor of acetylcholinesterase is 3-(diethylaminophenyl) phenyl carbamate with the value of IC50 = 1.52 uM and the most effective inhibitor of butyrylcholinesterase is 3-(diethylaminophenyl) (3-nitrophenyl) carbamate with the value of IC50 = 1.70 uM." . . "[0DC3B211DE91]" . "2"^^ . "8"^^ . .