"Knotek, Petr" . . . "414" . "NL - Nizozemsko" . "RIV/00216275:25310/11:39892210!RIV12-GA0-25310___" . "Prednisolone-alpha-cyclodextrin-star poly(ethylene glycol) polypseudorotaxane with delayed pH-sensitivity as a targeted drug delivery system" . "Prednisolone-alpha-cyclodextrin-star poly(ethylene glycol) polypseudorotaxane with delayed pH-sensitivity as a targeted drug delivery system"@en . "Prednisolone-alpha-cyclodextrin-star poly(ethylene glycol) polypseudorotaxane with delayed pH-sensitivity as a targeted drug delivery system" . . . "The acylation of prednisolone 20-hydrazone with star poly(ethylene glycol) tetracarboxylic acid (M = 20,000) has been used to prepare the corresponding pH-sensitive conjugate. With alpha-cyclodextrin, this conjugate forms a polypseudorotaxane, which was characterised by means of (1)H NMR spectra, powder X-ray diffraction patterns and STM microscopy. The rate of acid-catalysed hydrolysis of the conjugate was studied under in vitro conditions in model media of hydrochloric acid solutions, phosphate and acetate buffers (pH 2-5.8). The acid-catalysed hydrolysis (at pH 2) of the polypseudorotaxane was ca 3.5 times slower than that of the original conjugate. After 1 h in this medium, 86% of the covalently attached prednisolone remained unchanged. The prepared polypseudorotaxane represents a promising peroral transport system of prednisolone with a pH-sensitive linker with delayed acid-catalysed hydrolysis thanks to protection at the molecular level using alpha-cyclodextrin."@en . "0378-5173" . "6"^^ . "6"^^ . "B\u00EDlkov\u00E1, Eli\u0161ka" . . "10.1016/j.ijpharm.2011.04.060" . . . . . . . "1-2" . . "Imramovsk\u00FD, Ale\u0161" . "Prednisolone-alpha-cyclodextrin-star poly(ethylene glycol) polypseudorotaxane with delayed pH-sensitivity as a targeted drug delivery system"@en . . . . "RIV/00216275:25310/11:39892210" . "222832" . . "000292795500006" . "[1A83CB8C74A3]" . . "The acylation of prednisolone 20-hydrazone with star poly(ethylene glycol) tetracarboxylic acid (M = 20,000) has been used to prepare the corresponding pH-sensitive conjugate. With alpha-cyclodextrin, this conjugate forms a polypseudorotaxane, which was characterised by means of (1)H NMR spectra, powder X-ray diffraction patterns and STM microscopy. The rate of acid-catalysed hydrolysis of the conjugate was studied under in vitro conditions in model media of hydrochloric acid solutions, phosphate and acetate buffers (pH 2-5.8). The acid-catalysed hydrolysis (at pH 2) of the polypseudorotaxane was ca 3.5 times slower than that of the original conjugate. After 1 h in this medium, 86% of the covalently attached prednisolone remained unchanged. The prepared polypseudorotaxane represents a promising peroral transport system of prednisolone with a pH-sensitive linker with delayed acid-catalysed hydrolysis thanks to protection at the molecular level using alpha-cyclodextrin." . . . . "Prednisolone; Polypseudorotaxane; PEG; Pro-drugs; pH-sensitivity"@en . "Bene\u0161, Ludv\u00EDk" . . . "25310" . "P(GAP106/11/0058), Z(MSM0021627501)" . . . "Sedl\u00E1k, Milo\u0161" . "Ch\u00E1rov\u00E1, Petra" . . "International Journal of Pharmaceutics" . "6"^^ .