"P(NS9831), Z(MSM0021627502)" . "25310" . "RIV/00216275:25310/11:39883557!RIV12-MZ0-25310___" . . "000295700500019" . . "4"^^ . . . "Mixed dissociation constant(s) of two nitrogen-containing bisphosphonate acids HJL, alendronate and ibandronate, at various ionic strengths I in the range of (0.02 to 0.30)I and (298.15 and 310.15) K have been determined. The estimate of ill-conditioned group parameters has a great influence on a systematic error in the estimated pKa, and therefore it makes the computational strategy important. The thermodynamic dissociation constant pKa T was estimated by a nonlinear regression of {pKa, I} data and a Debye-Huckel equation. A goodness-of-fit test based on regression diagnostics is the measure of a reliability of parameters and proves that reliable estimates for alendronate pKa2 T = 2.60(1) and 2.76(1), pKa3 T = 6.73(1) and 6.77(1), pKa4 T = 11.51(2) and 11.29(1), and pKa5 T = 12.44(3) and 11.82(3) at (298.15 and 310.15) K, respectively, and for ibandronate pKa2 T = 2.33(1) and 2.50(1), pKa3 T = 6.31(1) and 6.37(1), and pKa4 T = 10.74(1) and 10.65(1) at (298.15 and 310.15) K, respectively, were found."@en . "Thermodynamic dissociation constants of alendronate and ibandronate by regression analysis of potentiometric data" . "2"^^ . . "RIV/00216275:25310/11:39883557" . "Pek\u00E1rek, Tom\u00E1\u0161" . . "Mixed dissociation constant(s) of two nitrogen-containing bisphosphonate acids HJL, alendronate and ibandronate, at various ionic strengths I in the range of (0.02 to 0.30)I and (298.15 and 310.15) K have been determined. The estimate of ill-conditioned group parameters has a great influence on a systematic error in the estimated pKa, and therefore it makes the computational strategy important. The thermodynamic dissociation constant pKa T was estimated by a nonlinear regression of {pKa, I} data and a Debye-Huckel equation. A goodness-of-fit test based on regression diagnostics is the measure of a reliability of parameters and proves that reliable estimates for alendronate pKa2 T = 2.60(1) and 2.76(1), pKa3 T = 6.73(1) and 6.77(1), pKa4 T = 11.51(2) and 11.29(1), and pKa5 T = 12.44(3) and 11.82(3) at (298.15 and 310.15) K, respectively, and for ibandronate pKa2 T = 2.33(1) and 2.50(1), pKa3 T = 6.31(1) and 6.37(1), and pKa4 T = 10.74(1) and 10.65(1) at (298.15 and 310.15) K, respectively, were found." . . "Journal of Chemical and Engineering Data" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "[9EA7CDD4A729]" . "7"^^ . . . "Meloun, Milan" . "Ibandronate; Alendronate; HYPERQUAD; ESAB; dissociation constant; potentiometric titration"@en . . "10" . "10.1021/je200512e" . "Netolick\u00E1, Lucie" . . . . . . "0021-9568" . "56" . "Thermodynamic dissociation constants of alendronate and ibandronate by regression analysis of potentiometric data"@en . "Thermodynamic dissociation constants of alendronate and ibandronate by regression analysis of potentiometric data"@en . . . "Feren\u010D\u00EDkov\u00E1, Zuzana" . "Thermodynamic dissociation constants of alendronate and ibandronate by regression analysis of potentiometric data" . . "235209" . . . .