"Feren\u010D\u00EDkov\u00E1, Zuzana" . "10.1016/j.jct.2011.01.012" . . . "25310" . . "Determination of the thermodynamic dissociation constant of capecitabine using spectrophotometric and potentiometric titration data" . "8"^^ . . . . . "Journal of Chemical Thermodynamics" . "Vr\u00E1na, Ale\u0161" . "193914" . "Determination of the thermodynamic dissociation constant of capecitabine using spectrophotometric and potentiometric titration data"@en . . "Meloun, Milan" . . . "Determination of the thermodynamic dissociation constant of capecitabine using spectrophotometric and potentiometric titration data" . "RIV/00216275:25310/11:39883426!RIV12-MZ0-25310___" . "3"^^ . "43" . . . . "Capecitabine has been studied by a combined potentiometric and spectrophotometric titration at T = (298.15, 310.15) K at different ionic strengths. The thermodynamic dissociation constant was estimated by non-linear regression of (pK(a), I) data: pK(a)(T) = 8.97(1) at T = 298.15 K and pK(a)(T) = 8.74(0) at T = 310.15 K, where the figure in the brackets is the standard deviation in last significant digits. Thermodynamic parameters Delta H degrees/kJ.mol(-1) and Delta S degrees/J.K-1.mol(-1) have been determined from the temperature variation of thermodynamic dissociation constants. The value of enthalpy Delta H degrees = 33.9 kJ.mol(-1) shows the dissociation process is endothermic and the value of entropy Delta S degrees = -51.9J.K-1.mol(-1) indicates that the dissociation is not a spontaneous process." . "2"^^ . "RIV/00216275:25310/11:39883426" . "Determination of the thermodynamic dissociation constant of capecitabine using spectrophotometric and potentiometric titration data"@en . . . "[0854D52DE9B4]" . . . . "P(NS9831), Z(MSM0021627502)" . "Capecitabine has been studied by a combined potentiometric and spectrophotometric titration at T = (298.15, 310.15) K at different ionic strengths. The thermodynamic dissociation constant was estimated by non-linear regression of (pK(a), I) data: pK(a)(T) = 8.97(1) at T = 298.15 K and pK(a)(T) = 8.74(0) at T = 310.15 K, where the figure in the brackets is the standard deviation in last significant digits. Thermodynamic parameters Delta H degrees/kJ.mol(-1) and Delta S degrees/J.K-1.mol(-1) have been determined from the temperature variation of thermodynamic dissociation constants. The value of enthalpy Delta H degrees = 33.9 kJ.mol(-1) shows the dissociation process is endothermic and the value of entropy Delta S degrees = -51.9J.K-1.mol(-1) indicates that the dissociation is not a spontaneous process."@en . . . . "6" . . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . "HYPERQUAD; ESAB2M; SQUAD; SPECFIT; Capecitabine; Dissociation constant; Potentiometric titration; Spectrophotometric titration"@en . "000289600400013" . "0021-9614" .