. "Identification of New Phase II Metabolites of Xanthohumol in Rat in vivo Biotransformation of Hop Extracts Using High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry"@en . "262711" . "0021-9673" . "Polyphenolic compounds occurring in hop extracts and their phases I and II metabolites formed during in vivo rat biotransformation have been analyzed using HPLC/MS/MS with electrospray ionization and QqTOF analyzer. Both ESI polarity modes are used for the determination of molecular weights in the full scan spectra and the structural information in subsequent tandem mass spectra. The emphasis is given on the elemental composition determination of individual metabolites based on accurate masses typically better than 5 ppm even with the external calibration. Advanced software tools are used for the metabolite identification using the comparison of the blank chromatogram with the real incubation sample together with the software prediction and detection of possible metabolites. More than ten compounds originating from the hops are identified in rat feces, two of them belong to phase I metabolites and five compounds are phase II metabolites." . . "RIV/00216275:25310/10:39881357!RIV11-GA0-25310___" . "Vrublov\u00E1, Eva" . "Journal of Chromatography A" . . "25310" . . . . "HPLC/MS/MS; Phenolic compounds; Sulfate; Metabolites; Hop; Xanthohumol"@en . "Identification of New Phase II Metabolites of Xanthohumol in Rat in vivo Biotransformation of Hop Extracts Using High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry" . . "\u0160im\u00E1nek, Vil\u00EDm" . "1217" . . "Hol\u010Dapek, Michal" . . . . "Jir\u00E1sko, Robert" . "2"^^ . "25" . "P(GA203/08/1536), Z(MSM0021627502), Z(MSM6198959216)" . . . . . "NL - Nizozemsko" . . "Identification of New Phase II Metabolites of Xanthohumol in Rat in vivo Biotransformation of Hop Extracts Using High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry" . . . . "5"^^ . "000278779000018" . "Polyphenolic compounds occurring in hop extracts and their phases I and II metabolites formed during in vivo rat biotransformation have been analyzed using HPLC/MS/MS with electrospray ionization and QqTOF analyzer. Both ESI polarity modes are used for the determination of molecular weights in the full scan spectra and the structural information in subsequent tandem mass spectra. The emphasis is given on the elemental composition determination of individual metabolites based on accurate masses typically better than 5 ppm even with the external calibration. Advanced software tools are used for the metabolite identification using the comparison of the blank chromatogram with the real incubation sample together with the software prediction and detection of possible metabolites. More than ten compounds originating from the hops are identified in rat feces, two of them belong to phase I metabolites and five compounds are phase II metabolites."@en . "RIV/00216275:25310/10:39881357" . "Ulrichov\u00E1, Jitka" . . . . "9"^^ . "[CE448FE681BA]" . "Identification of New Phase II Metabolites of Xanthohumol in Rat in vivo Biotransformation of Hop Extracts Using High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry"@en .