. . . "Z(MSM0021627501), Z(MSM0021627502)" . "25310" . "Prednisolone-alfa-cyclodextrin-star PEG polypseudorotaxanes with controlled drug delivery properties"@en . . "8"^^ . "RIV/00216275:25310/10:39881308!RIV11-MSM-25310___" . "Sedl\u00E1k, Milo\u0161" . . "Prednisolone-alfa-cyclodextrin-star PEG polypseudorotaxanes with controlled drug delivery properties" . . . . "000284065000022" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "[47732377AB6F]" . "drug delivery; polypseudorotaxanes; Prednisolone-alpha-cyclodextrin-star PEG"@en . "Prednisolone-alfa-cyclodextrin-star PEG polypseudorotaxanes with controlled drug delivery properties"@en . . "Organic & Biomolecular Chemistry" . . "23" . "1477-0520" . "RIV/00216275:25310/10:39881308" . . . . "Dvo\u0159\u00E1k, Bohuslav" . . "6"^^ . . "Knotek, Petr" . "6"^^ . "B\u00EDlkov\u00E1, Eli\u0161ka" . "Bene\u0161, Ludv\u00EDk" . . "Prednisolone-alfa-cyclodextrin-star PEG polypseudorotaxanes with controlled drug delivery properties" . "The reaction of alpha-amino-omega-methoxypoly(ethylene glycol) [M = 5000] or star alpha-amino-poly(ethylene glycol) [M = 20 000] with hemiesters of prednisolone dicarboxylic acids (succinic, glutaric, adipic, phthalic acid) has been used to prepare the corresponding conjugates. The rate of esterase catalyzed hydrolysis of the conjugates is controlled by the molecular mass of poly(ethylene glycol) and the length of the linker between prednisolone and poly(ethylene glycol) (tau(1/2) similar to 5-0.5 h). The enzymatic hydrolysis proceeds most rapidly at conjugates with linkers derived from adipic and phthalic acids. The synthesized conjugates form polypseudorotaxanes with alpha-cyclodextrin which were characterized by 2D NOESY NMR spectra, powder X-ray diffraction patterns and in one case also by STM microscopy."@en . . "8" . . "Ventura, Karel" . "The reaction of alpha-amino-omega-methoxypoly(ethylene glycol) [M = 5000] or star alpha-amino-poly(ethylene glycol) [M = 20 000] with hemiesters of prednisolone dicarboxylic acids (succinic, glutaric, adipic, phthalic acid) has been used to prepare the corresponding conjugates. The rate of esterase catalyzed hydrolysis of the conjugates is controlled by the molecular mass of poly(ethylene glycol) and the length of the linker between prednisolone and poly(ethylene glycol) (tau(1/2) similar to 5-0.5 h). The enzymatic hydrolysis proceeds most rapidly at conjugates with linkers derived from adipic and phthalic acids. The synthesized conjugates form polypseudorotaxanes with alpha-cyclodextrin which were characterized by 2D NOESY NMR spectra, powder X-ray diffraction patterns and in one case also by STM microscopy." . . . "281163" . .