"Vyu\u017Eit\u00ED terpenov\u00FDch deriv\u00E1t\u016F v synt\u00E9ze terpen-imidazol\u016F s aplikac\u00ED v nitroaldolov\u00E9 reakci"@cs . "Bure\u0161, Filip" . "Utilizing terpene derivatives in the synthesis of annulated terpene-imidazoles with application in the nitroaldol reaction" . . "25310" . "[2C7ABD738AB1]" . . "imidazole; terpenes; asymmetric catalysis"@en . "Two classes of terpene derivatives (diketones and monoximes) were condensed into annulated terpeneimidazoles using two general methods. Method A, involving the condensation of terpene diketones and aldehydes, gave lower yields than Method B, which employed terpene monoximes and amines. The mechanism of Method B is discussed. Using both methods, overall 11 new imidazole ligands were synthesized and fully characterized. The molecular structures of the side product 16 and intermediate 4b were also characterized by X-ray analysis. Regarding 1a, N-methylation and subsequent ortho-lithiation and quenching with diphenylphosphinechloride were proven. The synthesized ligands were tested in the Henry reaction providing reaction times 24?72 h and enantioselectivities up to 32% especially for the pyridine 2-substituted ligands 1c, 2c, 3b and N,P-ligand 17." . . "0957-4166" . "RIV/00216275:25310/08:00007557!RIV09-GA0-25310___" . . . . "P(GP203/07/P013), Z(MSM0021627501)" . "21" . . "\u0160imon, Petr" . "Kulh\u00E1nek, Ji\u0159\u00ED" . "Dv\u011B t\u0159\u00EDdy deriv\u00E1t\u016F terpen\u016F (diketony a monoximy) byly kondenzov\u00E1ny na deriv\u00E1ty imidazolu s vyu\u017Eit\u00EDm dvou metod. Metoda A zahrnuje kondenzaci diketon\u016F s aldehydy, metoda B pak reakci monoxim\u016F s aminy. Mechanismus metody je rovn\u011B\u017E diskutov\u00E1n. Celkem bylo syntetizov\u00E1no a charakterizov\u00E1no 11 nov\u00FDch deriv\u00E1t\u016F imidazolu. Dva intermedi\u00E1ty/vedlej\u0161\u00ED produkty byly rovn\u011B\u017E charakterizov\u00E1ny pomoci X-ray anal\u00FDzy. Syntetizovan\u00E9 ligandy byly aplikov\u00E1ny v asymetrick\u00E9 Henryho reakci, kdy bylo dosa\u017Eeno reak\u010Dn\u00EDch \u010Das\u016F 24-72 h a enantioselektivit do 32%."@cs . "Schweizer, Bernd" . "8"^^ . . . "Vyu\u017Eit\u00ED terpenov\u00FDch deriv\u00E1t\u016F v synt\u00E9ze terpen-imidazol\u016F s aplikac\u00ED v nitroaldolov\u00E9 reakci"@cs . . "4"^^ . . "Utilizing terpene derivatives in the synthesis of annulated terpene-imidazoles with application in the nitroaldol reaction"@en . "2"^^ . . . "Tetrahedron:Asymmetry" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "RIV/00216275:25310/08:00007557" . . "Utilizing terpene derivatives in the synthesis of annulated terpene-imidazoles with application in the nitroaldol reaction"@en . . "Utilizing terpene derivatives in the synthesis of annulated terpene-imidazoles with application in the nitroaldol reaction" . "402012" . . "Two classes of terpene derivatives (diketones and monoximes) were condensed into annulated terpeneimidazoles using two general methods. Method A, involving the condensation of terpene diketones and aldehydes, gave lower yields than Method B, which employed terpene monoximes and amines. The mechanism of Method B is discussed. Using both methods, overall 11 new imidazole ligands were synthesized and fully characterized. The molecular structures of the side product 16 and intermediate 4b were also characterized by X-ray analysis. Regarding 1a, N-methylation and subsequent ortho-lithiation and quenching with diphenylphosphinechloride were proven. The synthesized ligands were tested in the Henry reaction providing reaction times 24?72 h and enantioselectivities up to 32% especially for the pyridine 2-substituted ligands 1c, 2c, 3b and N,P-ligand 17."@en . . . "19" .