"Neline\u00E1rn\u00ED regresn\u00ED anal\u00FDzou byly ze z\u00E1vislosti sm\u00ED\u0161en\u00FDch disocia\u010Dn\u00EDch konstant na iontov\u00E9 s\u00EDle vy\u010D\u00EDsleny termodynamick\u00E9 disocia\u010Dn\u00ED konstanty p\u0159i teplot\u011B 25\u00B0C a 37\u00B0C pro camptothecin pKTa,1 = 2.90(7) a 3.02(8), pKTa,2 = 10.18(30) a 10.23(8), pro 7-ethyl-10-hydroxycamptothecin, pKTa,1 = 3.11(2) a 2.46(6), pKTa,2 = 8.91(4) a 8.74(3), pKTa,3 = 9.70(3) a 9.47(8), pro 10-hydroxycamptothecin pKTa,1 = 2.93(4) a 2.84(5), pKTa,2 = 8.93(2) a 8.92(2), pKTa,3 = 9.45(10) a 9.98(4) a pro 7-ethylcamptothecin pKTa,1 = 3.10(4) a 3.30(16), pKTa,2 = 9.94(9) a 10.98(18). Sm\u00ED\u0161en\u00E9 disocia\u010Dn\u00ED konstanty byly vyhodnoceny regresn\u00ED anal\u00FDzou spekter programy SQUAD(84) a SPECFIT/32." . . "[48916332436E]" . "13"^^ . "Spectrophotometric Determination of Thermodynamic Dissociation Constants of Selected Anti-tumor Drugs"@en . . . "The thermodynamic dissociation constants pKTa were estimated by nonlinear regression of {pKa, I} data at 25\u00B0C and 37\u00B0C: for camptothecine pKTa,1 = 2.90(7) and 3.02(8), pKTa,2 = 10.18(30) and 10.23(8), for 7-ethyl-10-hydroxycamptothecine, pKTa,1 = 3.11(2) and 2.46(6), pKTa,2 = 8.91(4) and 8.74(3), pKTa,3 = 9.70(3) and 9.47(8), for 10-hydroxycamptothecine pKTa,1 = 2.93(4) and 2.84(5), pKTa,2 = 8.93(2) and 8.92(2), pKTa,3 = 9.45(10) and 9.98(4) and for 7-ethylcamptothecine pKTa,1 = 3.10(4) and 3.30(16), pKTa,2 = 9.94(9) and 10.98(18). The mixed dissociation constants were determined with the use of two programs, SPECFIT32 and SQUAD(84)."@en . . . . . . . "Sborn\u00EDk p\u0159\u00EDsp\u011Bvk\u016F ze semin\u00E1\u0159e IX. Monitorov\u00E1n\u00ED cizorod\u00FDch l\u00E1tek v \u017Eivotn\u00EDm prost\u0159ed\u00ED" . "Pardubice" . "451602" . "Univerzita Pardubice" . . "Spectrophotometric Determination of Thermodynamic Dissociation Constants of Selected Anti-tumor Drugs"@en . "Spektrofotometrick\u00E9 stanoven\u00ED termodynamick\u00FDch disocia\u010Dn\u00EDch konstant vybran\u00FDch cytostatik"@cs . "RIV/00216275:25310/07:00006025!RIV08-MSM-25310___" . . . "978-80-7194-953-4" . . "Spektrofotometrick\u00E9 stanoven\u00ED termodynamick\u00FDch disocia\u010Dn\u00EDch konstant vybran\u00FDch cytostatik"@cs . . "RIV/00216275:25310/07:00006025" . "P(NR9055), Z(MSM0021627502)" . . "1"^^ . . "Meloun, Milan" . "2"^^ . . "Neline\u00E1rn\u00ED regresn\u00ED anal\u00FDzou byly ze z\u00E1vislosti sm\u00ED\u0161en\u00FDch disocia\u010Dn\u00EDch konstant na iontov\u00E9 s\u00EDle vy\u010D\u00EDsleny termodynamick\u00E9 disocia\u010Dn\u00ED konstanty p\u0159i teplot\u011B 25\u00B0C a 37\u00B0C pro camptothecin pKTa,1 = 2.90(7) a 3.02(8), pKTa,2 = 10.18(30) a 10.23(8), pro 7-ethyl-10-hydroxycamptothecin, pKTa,1 = 3.11(2) a 2.46(6), pKTa,2 = 8.91(4) a 8.74(3), pKTa,3 = 9.70(3) a 9.47(8), pro 10-hydroxycamptothecin pKTa,1 = 2.93(4) a 2.84(5), pKTa,2 = 8.93(2) a 8.92(2), pKTa,3 = 9.45(10) a 9.98(4) a pro 7-ethylcamptothecin pKTa,1 = 3.10(4) a 3.30(16), pKTa,2 = 9.94(9) a 10.98(18). Sm\u00ED\u0161en\u00E9 disocia\u010Dn\u00ED konstanty byly vyhodnoceny regresn\u00ED anal\u00FDzou spekter programy SQUAD(84) a SPECFIT/32."@cs . . "Bordovsk\u00E1, Sylva" . "29-41" . . . . "25310" . . "Spectrophotometric; spectra analysis; thermodynamic dissociation constant; nonlinear regression; camptothecine; 7-ethyl-10-hydroxycamptothecine; 10-hydroxycamptothecine; 7-ethylcamptothecine; SPECFIT32; SQUAD(84); INDICES"@en . "Spektrofotometrick\u00E9 stanoven\u00ED termodynamick\u00FDch disocia\u010Dn\u00EDch konstant vybran\u00FDch cytostatik" . "Spektrofotometrick\u00E9 stanoven\u00ED termodynamick\u00FDch disocia\u010Dn\u00EDch konstant vybran\u00FDch cytostatik" . . . .