. "7"^^ . "Inflammatory Profiling of Schwann Cells in Contact with Growing Axons Distal to Nerve Injury" . . "RIV/00216224:14740/14:00078951" . "April" . . "Inflammatory Profiling of Schwann Cells in Contact with Growing Axons Distal to Nerve Injury"@en . "21290" . "activated Schwann cell; growing axons; reinnervation; inflammatory mediators"@en . "3"^^ . . . . "000335836400001" . "Activated Schwann cells distal to nerve injury upregulate inflammatory mediators, including cytokines. The goal of the present study was to investigate expression of proinflammatory (IL-1b, TNFa) and anti-inflammatory cytokines (IL-4, IL-10) in activated Schwann cells in relation to growing axons distal to crush injury of rat sciatic nerves. Seven days fromsciatic nerve crush, transverse cryostat sections were cut 5 mm distal to lesion and incubated for double immunostaining to indicate Schwann cells (GFAP or S100b) and individual investigated cytokines or to demonstrate growing axons (GAP43). The Schwann cells of naive sciatic nerves and those removed from sham-operated rats displayed similar weak immunoreactivity for the investigated cytokines. In contrast, increased intensity of cytokine immunofluorescence was found in Schwann cells distal to crush lesion. The cytokinepositive Schwann cells were found in close contact with growing axons detected by immunostaining for GAP43."@en . . "Dubov\u00FD, Petr" . . . "3"^^ . "2014" . "Activated Schwann cells distal to nerve injury upregulate inflammatory mediators, including cytokines. The goal of the present study was to investigate expression of proinflammatory (IL-1b, TNFa) and anti-inflammatory cytokines (IL-4, IL-10) in activated Schwann cells in relation to growing axons distal to crush injury of rat sciatic nerves. Seven days fromsciatic nerve crush, transverse cryostat sections were cut 5 mm distal to lesion and incubated for double immunostaining to indicate Schwann cells (GFAP or S100b) and individual investigated cytokines or to demonstrate growing axons (GAP43). The Schwann cells of naive sciatic nerves and those removed from sham-operated rats displayed similar weak immunoreactivity for the investigated cytokines. In contrast, increased intensity of cytokine immunofluorescence was found in Schwann cells distal to crush lesion. The cytokinepositive Schwann cells were found in close contact with growing axons detected by immunostaining for GAP43." . . . "[B8E4AFF4A8AD]" . "Hradilov\u00E1 Sv\u00ED\u017Eensk\u00E1, Ivana" . "RIV/00216224:14740/14:00078951!RIV15-MSM-14740___" . . "Klus\u00E1kov\u00E1, Ilona" . . "http://www.hindawi.com/journals/bmri/2014/691041/" . "BioMed Research International" . "Inflammatory Profiling of Schwann Cells in Contact with Growing Axons Distal to Nerve Injury"@en . . . . "P(ED1.1.00/02.0068)" . . "10.1155/2014/691041" . "14740" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "2314-6133" . "Inflammatory Profiling of Schwann Cells in Contact with Growing Axons Distal to Nerve Injury" . .