"31091" . . . "IT - Italsk\u00E1 republika" . . "Tich\u00FD, Boris" . "14740" . "10"^^ . "Pavlov\u00E1, \u0160\u00E1rka" . "[D5EBC1BFB6D5]" . . . . "10.3324/haematol.2013.087593" . . "10"^^ . "Plevov\u00E1, Karla" . "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912964/pdf/0990329.pdf" . "Multiple productive immunoglobulin heavy chain gene rearrangements in chronic lymphocytic leukemia are mostly derived from independent clones"@en . . "Multiple productive immunoglobulin heavy chain gene rearrangements in chronic lymphocytic leukemia are mostly derived from independent clones" . . "10"^^ . "Chronic lymphocytic leukemia; immunoglobulin; B lymphocyte"@en . . "In chronic lymphocytic leukemia, usually a monoclonal disease, multiple productive immunoglobulin heavy chain gene rearrangements are identified sporadically. Prognostication of such cases based on immunoglobulin heavy variable gene mutational status can be problematic, especially if the different rearrangements have discordant mutational status. To gain insight into the possible biological mechanisms underlying the origin of the multiple rearrangements, we performed a comprehensive immunogenetic and immunophenotypic characterization of 31 cases with the multiple rearrangements identified in a cohort of 1147 patients with chronic lymphocytic leukemia. For the majority of cases (25/31), we provide evidence of the co-existence of at least two B lymphocyte clones with a chronic lymphocytic leukemia phenotype. We also identified clonal drifts in serial samples, likely driven by selection forces."@en . . . . "2" . . . "Brychtov\u00E1, Yvona" . "Multiple productive immunoglobulin heavy chain gene rearrangements in chronic lymphocytic leukemia are mostly derived from independent clones" . "Bur\u010Dkov\u00E1, Kate\u0159ina" . "Doubek, Michael" . . "Skuhrov\u00E1 Francov\u00E1, Hana" . . . . "RIV/00216224:14740/14:00077731" . "Mal\u010D\u00EDkov\u00E1, Jitka" . . "000336253900026" . . "RIV/00216224:14740/14:00077731!RIV15-MSM-14740___" . "P(ED1.1.00/02.0068), P(EE2.3.20.0045), P(NT13493), S" . . . "Haematologica" . "Mayer, Ji\u0159\u00ED" . "0390-6078" . "In chronic lymphocytic leukemia, usually a monoclonal disease, multiple productive immunoglobulin heavy chain gene rearrangements are identified sporadically. Prognostication of such cases based on immunoglobulin heavy variable gene mutational status can be problematic, especially if the different rearrangements have discordant mutational status. To gain insight into the possible biological mechanisms underlying the origin of the multiple rearrangements, we performed a comprehensive immunogenetic and immunophenotypic characterization of 31 cases with the multiple rearrangements identified in a cohort of 1147 patients with chronic lymphocytic leukemia. For the majority of cases (25/31), we provide evidence of the co-existence of at least two B lymphocyte clones with a chronic lymphocytic leukemia phenotype. We also identified clonal drifts in serial samples, likely driven by selection forces." . . "Multiple productive immunoglobulin heavy chain gene rearrangements in chronic lymphocytic leukemia are mostly derived from independent clones"@en . . . "Posp\u00ED\u0161ilov\u00E1, \u0160\u00E1rka" . "99" . .