"The Wnt signaling pathway is required during embryonic development and for the maintenance of homeostasis in adult tissues. However, aberrant activation of the pathway is implicated in a number of human disorders, including cancer of the gastrointestinal tract, breast, liver, melanoma, and hematologic malignancies. In this study, we identified monensin, a polyether ionophore antibiotic, as a potent inhibitor of Wnt signaling. The inhibitory effect of monensin on the Wnt/beta-catenin signaling cascade was observed in mammalian cells stimulated with Wnt ligands, glycogen synthase kinase-3 inhibitors, and in cells transfected with beta-catenin expression constructs. Furthermore, monensin suppressed the Wnt-dependent tail fin regeneration in zebrafish and Wnt- or beta-catenin-induced formation of secondary body axis in Xenopus embryos. In Wnt3a-activated HEK293 cells, monensin blocked the phoshorylation of Wnt coreceptor low-density lipoprotein receptor related protein 6 and promoted its degradation." . . . "\u0160loncov\u00E1, Eva" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "RIV/00216224:14740/14:00075743!RIV15-MSM-14740___" . "Bart\u016Fn\u011Bk, Petr" . . "Molecular Cancer Therapeutics" . "Monensin Inhibits Canonical Wnt Signaling in Human Colorectal Cancer Cells and Suppresses Tumor Growth in Multiple Intestinal Neoplasia Mice" . . "The Wnt signaling pathway is required during embryonic development and for the maintenance of homeostasis in adult tissues. However, aberrant activation of the pathway is implicated in a number of human disorders, including cancer of the gastrointestinal tract, breast, liver, melanoma, and hematologic malignancies. In this study, we identified monensin, a polyether ionophore antibiotic, as a potent inhibitor of Wnt signaling. The inhibitory effect of monensin on the Wnt/beta-catenin signaling cascade was observed in mammalian cells stimulated with Wnt ligands, glycogen synthase kinase-3 inhibitors, and in cells transfected with beta-catenin expression constructs. Furthermore, monensin suppressed the Wnt-dependent tail fin regeneration in zebrafish and Wnt- or beta-catenin-induced formation of secondary body axis in Xenopus embryos. In Wnt3a-activated HEK293 cells, monensin blocked the phoshorylation of Wnt coreceptor low-density lipoprotein receptor related protein 6 and promoted its degradation."@en . . "Gradl, Dietmar" . . . "Hor\u00E1zn\u00E1, Monika" . "Jind\u0159ich, Jind\u0159ich" . . "Monensin Inhibits Canonical Wnt Signaling in Human Colorectal Cancer Cells and Suppresses Tumor Growth in Multiple Intestinal Neoplasia Mice"@en . . "[06514E1E5A2A]" . "Monensin Inhibits Canonical Wnt Signaling in Human Colorectal Cancer Cells and Suppresses Tumor Growth in Multiple Intestinal Neoplasia Mice" . . "Ko\u0159\u00EDnek, Vladim\u00EDr" . . "Krausov\u00E1, Michaela" . "4" . "1"^^ . "14740" . "Monensin Inhibits Canonical Wnt Signaling in Human Colorectal Cancer Cells and Suppresses Tumor Growth in Multiple Intestinal Neoplasia Mice"@en . . . "I, P(ED1.1.00/02.0068), P(FR-TI4/802), P(GAP305/12/2347), P(LM2011022), P(LO1220), S" . "Stan\u010D\u00EDkov\u00E1, Jitka" . . . "T\u016Fmov\u00E1, Lucie" . . "http://mct.aacrjournals.org/content/13/4/812.long" . . . "Pombinho, Antonio" . "13" . "Vojt\u011Bchov\u00E1, Martina" . "Macho\u0148ov\u00E1, Olga" . "000334342300005" . . . . "10.1158/1535-7163.MCT-13-0625" . "11"^^ . "1535-7163" . . . "14"^^ . . . . "30344" . . "Zdr\u00E1hal, Zbyn\u011Bk" . . "BETA-CATENIN; CYCLE ARREST; COLON-CANCER; CARCINOMA-CELLS; LEUKEMIA-CELLS; IN-VIVO; APOPTOSIS; ACTIVATION; APC; GENES"@en . "RIV/00216224:14740/14:00075743" . "K\u0159\u00ED\u017E, V\u00EDt\u011Bzslav" .