. "Carcinogenesis" . "0143-3334" . "000345835800017" . "Machala, Miroslav" . . "Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway" . . "35" . . "RIV/00216224:14740/14:00073973!RIV15-MSM-14740___" . . "CYP1B1; inflammation; p38 MAP kinase; MSK; metabolism of carcinogens"@en . "\u0160merdov\u00E1, Lenka" . "Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway" . . "3"^^ . . . "Kab\u00E1tkov\u00E1, Mark\u00E9ta" . . "Vondr\u00E1\u010Dek, Jan" . . . . . "Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway"@en . "Cytochrome P450 1B1 (CYP1B1) is an enzyme that has a unique tumor-specific pattern of expression and is capable of bioactivating a wide range of carcinogenic compounds. We have reported previously that coordinated upregulation of CYP1B1 by inflammatory cytokines, such as tumor necrosis factor-delta(TNF-delta) and the aryl hydrocarbon receptor ligands, may increase bioactivation of promutagens, such as benzo[a]pyrene (BaP) in epithelial cells. Here, we extend those studies by describing a novel mechanism participating in the regulation of CYP1B1 expression, which involves activation of the p38 mitogen-activated protein kinase (p38) and mitogen- and stress-activated protein kinase 1 (MSK1). Using inhibitors of p38 and MSKs, as well as mouse embryonic cells derived from p38delta-deficient and MSK1/2 double knockout mice, we show here that TNF-delta potentiates CYP1B1 upregulation via the p38/MSK1 kinase cascade." . . "Bla\u017Eek, Dalibor" . "11" . . . . . . "10"^^ . "7"^^ . "52125" . "[98F87E081494]" . . "Cytochrome P450 1B1 (CYP1B1) is an enzyme that has a unique tumor-specific pattern of expression and is capable of bioactivating a wide range of carcinogenic compounds. We have reported previously that coordinated upregulation of CYP1B1 by inflammatory cytokines, such as tumor necrosis factor-delta(TNF-delta) and the aryl hydrocarbon receptor ligands, may increase bioactivation of promutagens, such as benzo[a]pyrene (BaP) in epithelial cells. Here, we extend those studies by describing a novel mechanism participating in the regulation of CYP1B1 expression, which involves activation of the p38 mitogen-activated protein kinase (p38) and mitogen- and stress-activated protein kinase 1 (MSK1). Using inhibitors of p38 and MSKs, as well as mouse embryonic cells derived from p38delta-deficient and MSK1/2 double knockout mice, we show here that TNF-delta potentiates CYP1B1 upregulation via the p38/MSK1 kinase cascade."@en . "RIV/00216224:14740/14:00073973" . "Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway"@en . "14740" . . . "10.1093/carcin/bgu190" . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "Svobodov\u00E1, Jana" . . "http://www.ncbi.nlm.nih.gov/pubmed/25233930" . "P(ED1.1.00/02.0068), P(EE2.3.30.0030), P(GA14-09979S), P(GAP503/11/1227), Z(MZE0002716202)" . "Kohoutek, Ji\u0159\u00ED" .