. . . . "RNA; large ribosomal subunit; sequence alignments; molecular dynamics simulations; L1 stalk"@en . . "Ko\u010Da, Jaroslav" . . "000318891700015" . . . . . . "I, P(ED1.1.00/02.0068), P(GBP305/12/G034)" . "10.1021/jp401482m" . . . "16"^^ . . . "L1 stalk is a prominent mobile element of the large ribosomal subunit. We explore the structure and dynamics of its non-canonical rRNA elements, which include two kink-turns, an internal loop and a tetraloop. We use bioinformatics to identify the L1 stalk RNA conservation patterns and carry out over 11.5 us of MD simulations for a set of systems ranging from isolated RNA building blocks up to complexes of L1 stalk rRNA with the L1 protein and tRNA fragment. We show that the L1 stalk tetraloop has unusual GNNA or UNNG conservation pattern deviating from major GNRA and YNMG RNA tetraloop families. We suggest that this deviation is related to a highly conserved tertiary contact within the L1 stalk. The available X-ray structures contain only UCCG tetraloops which in addition differ in orientation (anti vs syn) of the guanine."@en . . "18" . . . "L1 stalk is a prominent mobile element of the large ribosomal subunit. We explore the structure and dynamics of its non-canonical rRNA elements, which include two kink-turns, an internal loop and a tetraloop. We use bioinformatics to identify the L1 stalk RNA conservation patterns and carry out over 11.5 us of MD simulations for a set of systems ranging from isolated RNA building blocks up to complexes of L1 stalk rRNA with the L1 protein and tRNA fragment. We show that the L1 stalk tetraloop has unusual GNNA or UNNG conservation pattern deviating from major GNRA and YNMG RNA tetraloop families. We suggest that this deviation is related to a highly conserved tertiary contact within the L1 stalk. The available X-ray structures contain only UCCG tetraloops which in addition differ in orientation (anti vs syn) of the guanine." . "63450" . "Bioinformatics and Molecular Dynamics Simulation Study of L1 Stalk Non-Canonical rRNA Elements: Kink-turns, Loops, and Tetraloops"@en . "117" . "RIV/00216224:14740/13:00067973" . "1520-6106" . "JOURNAL OF PHYSICAL CHEMISTRY B" . "R\u00E9blov\u00E1, Kamila" . "http://dx.doi.org/10.1021/jp401482m" . "Bioinformatics and Molecular Dynamics Simulation Study of L1 Stalk Non-Canonical rRNA Elements: Kink-turns, Loops, and Tetraloops"@en . "3"^^ . . "Krepl, Miroslav" . "4"^^ . "Bioinformatics and Molecular Dynamics Simulation Study of L1 Stalk Non-Canonical rRNA Elements: Kink-turns, Loops, and Tetraloops" . "[9E4D962A16E5]" . . "Bioinformatics and Molecular Dynamics Simulation Study of L1 Stalk Non-Canonical rRNA Elements: Kink-turns, Loops, and Tetraloops" . "14740" . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "\u0160poner, Ji\u0159\u00ED" . "RIV/00216224:14740/13:00067973!RIV14-MSM-14740___" .