. "Vyzula, Rostislav" . "Glioblastoma multiforme (GBM) is the most frequent primary malignant brain tumor with very poor prognosis. Despite an optimal treatment composed of a maximal surgical resection followed an intense concomitant chemoradiotherapy with temozolomide and adjuvant temozolomide, the median of overall survival remains only 12-15 months from diagnosis. Because of a different response to treatment, it is very important to find new biomarkers that can be used in prediction of a clinical outcome in GBM patients, who underwent chemoradiotherapy. MicroRNAs are highly conserved, small, non-coding RNAs that function as post-transcriptional regulators of gene expression. Therefore, these molecules play key role in pathogenesis of many cancers, including GBM." . "RIV/00216224:14740/13:00065596!RIV14-MZ0-14740___" . . "\u0160\u00E1na, Ji\u0159\u00ED" . . . "14740" . "Expression analysis of microRNAs in relation to the chemoradioresistance of glioblastoma"@en . . "microRNA; chemoresistance; radioresistance; glioblastoma multiforme"@en . "Expression analysis of microRNAs in relation to the chemoradioresistance of glioblastoma" . "Kosa\u0159ov\u00E1, Zde\u0148ka" . . . "[1AC6274BC793]" . "RIV/00216224:14740/13:00065596" . . . "7"^^ . . . . . "Slab\u00FD, Ond\u0159ej" . "P(ED1.1.00/02.0068), P(NT13514)" . . . . "Expression analysis of microRNAs in relation to the chemoradioresistance of glioblastoma"@en . . "Be\u0161\u0161e, Andrej" . . "4"^^ . "Expression analysis of microRNAs in relation to the chemoradioresistance of glioblastoma" . "74343" . "Lakom\u00FD, Radek" . . . "Glioblastoma multiforme (GBM) is the most frequent primary malignant brain tumor with very poor prognosis. Despite an optimal treatment composed of a maximal surgical resection followed an intense concomitant chemoradiotherapy with temozolomide and adjuvant temozolomide, the median of overall survival remains only 12-15 months from diagnosis. Because of a different response to treatment, it is very important to find new biomarkers that can be used in prediction of a clinical outcome in GBM patients, who underwent chemoradiotherapy. MicroRNAs are highly conserved, small, non-coding RNAs that function as post-transcriptional regulators of gene expression. Therefore, these molecules play key role in pathogenesis of many cancers, including GBM."@en . . "Smr\u010Dka, Martin" .