. "D\u00EDky izolaci \u010Dist\u00E9ho rostlinn\u00E9ho delta-9 tetrahydrokanabinolu (THC) a stanoven\u00ED jeho chemick\u00E9ho vzorce v 60. letech minul\u00E9ho stolet\u00ED a n\u00E1sledn\u00E9ho zkoum\u00E1n\u00ED jeho farmakologick\u00E9ho mechanizmu p\u016Fsoben\u00ED byly identifikov\u00E1ny a v organizmu obratlovc\u016F v\u010Detn\u011B \u010Dlov\u011Bka zmapov\u00E1ny specifick\u00E9 kanabinoidn\u00ED receptory (jako prvn\u00ED podtypy CB1 a CB2 v 80. letech minul\u00E9ho stolet\u00ED) a posl\u00E9ze t\u00E9\u017E objeveny jejich endogenn\u00ED ligandy naz\u00FDvan\u00E9 dnes endokanabinoidy. Synt\u00E9za, uvol\u0148ov\u00E1n\u00ED a odbour\u00E1v\u00E1n\u00ED endokanabinoid\u016F, exprese a funkce kanabinoidn\u00EDch receptor\u016F jsou pak hlavn\u00EDmi charakteristikami takto objeven\u00E9ho tzv. \u201Eendokanabinoidn\u00EDho syst\u00E9mu\u201C, jeho\u017E fyziologick\u00E9 a patofyziologick\u00E9 \u00FAlohy je nutn\u00E9 poznat, aby bylo mo\u017En\u00E9 hledat mo\u017Enosti exogenn\u00EDho ovliv\u0148ov\u00E1n\u00ED v p\u0159\u00EDpad\u011B jejich deregulac\u00ED. Ukazuje se, \u017Ee v p\u0159\u00EDpad\u011B endokanabinoidn\u00EDho syst\u00E9mu mozku se modulace jeho aktivit m\u016F\u017Ee pod\u00EDlet na rozvoji \u0159ady psychiatrick\u00FDch poruch, ale tak\u00E9 mo\u017En\u00E1 p\u0159i jejich l\u00E9\u010Den\u00ED a prevenci." . "1211-7579" . . "4" . . . "169911" . . "RIV/00216224:14740/12:00063481" . "D\u00EDky izolaci \u010Dist\u00E9ho rostlinn\u00E9ho delta-9 tetrahydrokanabinolu (THC) a stanoven\u00ED jeho chemick\u00E9ho vzorce v 60. letech minul\u00E9ho stolet\u00ED a n\u00E1sledn\u00E9ho zkoum\u00E1n\u00ED jeho farmakologick\u00E9ho mechanizmu p\u016Fsoben\u00ED byly identifikov\u00E1ny a v organizmu obratlovc\u016F v\u010Detn\u011B \u010Dlov\u011Bka zmapov\u00E1ny specifick\u00E9 kanabinoidn\u00ED receptory (jako prvn\u00ED podtypy CB1 a CB2 v 80. letech minul\u00E9ho stolet\u00ED) a posl\u00E9ze t\u00E9\u017E objeveny jejich endogenn\u00ED ligandy naz\u00FDvan\u00E9 dnes endokanabinoidy. Synt\u00E9za, uvol\u0148ov\u00E1n\u00ED a odbour\u00E1v\u00E1n\u00ED endokanabinoid\u016F, exprese a funkce kanabinoidn\u00EDch receptor\u016F jsou pak hlavn\u00EDmi charakteristikami takto objeven\u00E9ho tzv. \u201Eendokanabinoidn\u00EDho syst\u00E9mu\u201C, jeho\u017E fyziologick\u00E9 a patofyziologick\u00E9 \u00FAlohy je nutn\u00E9 poznat, aby bylo mo\u017En\u00E9 hledat mo\u017Enosti exogenn\u00EDho ovliv\u0148ov\u00E1n\u00ED v p\u0159\u00EDpad\u011B jejich deregulac\u00ED. Ukazuje se, \u017Ee v p\u0159\u00EDpad\u011B endokanabinoidn\u00EDho syst\u00E9mu mozku se modulace jeho aktivit m\u016F\u017Ee pod\u00EDlet na rozvoji \u0159ady psychiatrick\u00FDch poruch, ale tak\u00E9 mo\u017En\u00E1 p\u0159i jejich l\u00E9\u010Den\u00ED a prevenci."@cs . . . "P(ED1.1.00/02.0068)" . . . "Psychiatrie" . "SOU\u010CASN\u00C9 POZN\u00C1V\u00C1N\u00CD V\u00DDZNAMU ENDOKANABINOIDN\u00CDHO SYST\u00C9MU U NEUROPSYCHIATRICK\u00DDCH PORUCH" . "RIV/00216224:14740/12:00063481!RIV13-MSM-14740___" . "CURRENT EXPLORING OF THE ENDOCANNABINOID SYSTEM VALUE IN NEUROPSYCHIATRIC DISORDERS"@en . "CURRENT EXPLORING OF THE ENDOCANNABINOID SYSTEM VALUE IN NEUROPSYCHIATRIC DISORDERS"@en . . "1"^^ . . "16" . "CZ - \u010Cesk\u00E1 republika" . . "http://www.tigis.cz/images/stories/psychiatrie/2012/04/08_sulcova_psych_4-12.pdf" . "[FC3F6314D16A]" . "SOU\u010CASN\u00C9 POZN\u00C1V\u00C1N\u00CD V\u00DDZNAMU ENDOKANABINOIDN\u00CDHO SYST\u00C9MU U NEUROPSYCHIATRICK\u00DDCH PORUCH"@cs . "14740" . . "SOU\u010CASN\u00C9 POZN\u00C1V\u00C1N\u00CD V\u00DDZNAMU ENDOKANABINOIDN\u00CDHO SYST\u00C9MU U NEUROPSYCHIATRICK\u00DDCH PORUCH" . "1"^^ . "Thanks to isolation and structural establishment of pure herbal delta-9 tetrahydrocannabinol (THC) in the 1960s and a subsequent investigation of its pharmacological mechanisms of action there were identified and mapped specific cannabinoid receptors in the vertebrate including human organisms (firstly in the 1980s subtypes CB1 and CB2). Subsequently their endogenous ligands, nowadays called endocannabinoids, were also discovered. Synthesis, release and breakdown of endocannabinoids, expression and functions of cannabinoid receptors are the key components of so-called \u201DEndocannabinoid System\u201D. In order to discover the ways how to manipulate this system and normalize eventual dysregulations, their physiological and pathophysiological roles should be clarified in detail initially. It has been shown that the modulation of the brain endocannabinoid system activities can be involved in the development of number of psychiatric disorders and perhaps also in their prevention and treatment."@en . . "endocannabinoid; pharmacology; neuropsychiatric disorders"@en . "\u0160ulcov\u00E1, Alexandra" . . "7"^^ . . "SOU\u010CASN\u00C9 POZN\u00C1V\u00C1N\u00CD V\u00DDZNAMU ENDOKANABINOIDN\u00CDHO SYST\u00C9MU U NEUROPSYCHIATRICK\u00DDCH PORUCH"@cs .