. . . "10.1039/c2mb25136a" . "A combined approach for the study of histone deacetylase inhibitors" . "\u0160ilerov\u00E1, Pavla" . "[37ECB5376C46]" . . . "histone acetylation; inhibitors of histone deacetylases; MALDI-MS; LC-MS/MS"@en . . "A combined approach for the study of histone deacetylase inhibitors"@en . "14740" . "RIV/00216224:14740/12:00060968!RIV13-MSM-14740___" . "Fajkusov\u00E1, Lenka" . "P(2B08060), P(ED1.1.00/02.0068)" . . "A combined approach for the study of histone deacetylase inhibitors" . . . . "Fajkus, Ji\u0159\u00ED" . "http://pubs.rsc.org/en/Content/ArticleLanding/2012/MB/c2mb25136a" . . . . . "\u010Cin\u010D\u00E1rov\u00E1, Lenka" . . "8"^^ . . . "Kone\u010Dn\u00E1, Hana" . "RIV/00216224:14740/12:00060968" . . "9"^^ . . "A combined approach for the study of histone deacetylase inhibitors"@en . "8"^^ . "Zdr\u00E1hal, Zbyn\u011Bk" . "Molecular BioSystems" . . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "8" . . "Overexpression of histone deacetylases (HDACs), with consequent hypoacetylation of histones, is reportedly associated with transcriptional repression of tumour suppressor genes. Thus, inhibition of HDACs has emerged as a promising strategy in cancer therapy. In order to monitor the effects of potential HDAC inhibitors, a multi-level approach consisting of preliminary screening (measurement of HDAC activity and semi-quantitative evaluation of histone H4 modification profile by MALDI-TOF MS) and detailed analysis of histone modification forms (using 2-D AUT/AU PAGE and LC-ESI-IT MS) has been used in this study. The data obtained provide a global insight into the effects of HDAC inhibitors on the histone acetylation status that participates in gene transcription control."@en . . "Nov\u00E1kov\u00E1, Kate\u0159ina" . "1742-206X" . "11" . "000309481300017" . "Overexpression of histone deacetylases (HDACs), with consequent hypoacetylation of histones, is reportedly associated with transcriptional repression of tumour suppressor genes. Thus, inhibition of HDACs has emerged as a promising strategy in cancer therapy. In order to monitor the effects of potential HDAC inhibitors, a multi-level approach consisting of preliminary screening (measurement of HDAC activity and semi-quantitative evaluation of histone H4 modification profile by MALDI-TOF MS) and detailed analysis of histone modification forms (using 2-D AUT/AU PAGE and LC-ESI-IT MS) has been used in this study. The data obtained provide a global insight into the effects of HDAC inhibitors on the histone acetylation status that participates in gene transcription control." . "120066" . . . "Lochmanov\u00E1, Gabriela" .