"Zendulka, Ond\u0159ej" . . "5"^^ . "000300543900026" . "http://www.ncbi.nlm.nih.gov/pubmed/22167136" . "Effects of combined treatment with cognitive enhancer memantine and antidepressant fluoxetine on CYP2D2 metabolic activity in rats" . "0172-780X" . "\u0160ulcov\u00E1, Alexandra" . "The drug-drug interactions can result in alterations of the therapeutical responses. The present study was designed to investigate possible pharmacokinetic interactions between the cognitive agent memantine and the antidepressant fluoxetine combined often in treatments of cognitive disorders including Alzheimer disease. The attention was focused on changes of the cytochrome P450 2D2 isoenzyme activity in two animal models. METHODS AND DESIGN: The tested drugs were administered alone or in a combination to rat males and their effects on the 2D2 isoenzyme activity was determined after in vivo administration. The levels of marker dextromethorphan, its 2D2 specific metabolite dextrorphan were analyzed in plasma of rats and using the model of isolated perfused rat liver in the perfusion medium. The dextromethorphan/ dextrorphan (DEM/DEX) metabolic ratios were determined as a sign of inhibitory influences on CYP2D2." . "cytochrome P450; memantine; fluoxetine; rat; inhibition"@en . . . . "SE - \u0160v\u00E9dsk\u00E9 kr\u00E1lovstv\u00ED" . . "Ju\u0159ica, Jan" . "196615" . . "Effects of combined treatment with cognitive enhancer memantine and antidepressant fluoxetine on CYP2D2 metabolic activity in rats"@en . "32" . . . "RIV/00216224:14740/11:00055489!RIV12-MSM-14740___" . "RIV/00216224:14740/11:00055489" . "P(ED1.1.00/02.0068), Z(MSM0021622404)" . "Zahradn\u00EDkov\u00E1, Lucia" . . . . . . . "[D674B8877633]" . . . . "The drug-drug interactions can result in alterations of the therapeutical responses. The present study was designed to investigate possible pharmacokinetic interactions between the cognitive agent memantine and the antidepressant fluoxetine combined often in treatments of cognitive disorders including Alzheimer disease. The attention was focused on changes of the cytochrome P450 2D2 isoenzyme activity in two animal models. METHODS AND DESIGN: The tested drugs were administered alone or in a combination to rat males and their effects on the 2D2 isoenzyme activity was determined after in vivo administration. The levels of marker dextromethorphan, its 2D2 specific metabolite dextrorphan were analyzed in plasma of rats and using the model of isolated perfused rat liver in the perfusion medium. The dextromethorphan/ dextrorphan (DEM/DEX) metabolic ratios were determined as a sign of inhibitory influences on CYP2D2."@en . "Sabov\u00E1, Michaela" . . "Effects of combined treatment with cognitive enhancer memantine and antidepressant fluoxetine on CYP2D2 metabolic activity in rats" . . "6"^^ . . "Neuroendocrinology Letters" . . "Effects of combined treatment with cognitive enhancer memantine and antidepressant fluoxetine on CYP2D2 metabolic activity in rats"@en . . . "14740" . . "5" . "5"^^ .