"14740" . "P(ED1.1.00/02.0068), P(GA303/09/1168), P(GD301/09/H004), P(LC06030), P(ME08008), Z(MSM0021622413)" . "Round, Adam" . "188913" . "14"^^ . . . "Kosma, Paul" . "Lameign\u00E8re, Emilie" . "Burkholderia cenocepacia BC2L-C Is a Super Lectin with Dual Specificity and Proinflammatory Activity"@en . . "3"^^ . . . . . "Aubert, Daniel F" . "Balloy, Viviane" . "Cioci, Gianluca" . "[D20459CDB53C]" . . "Lectins and adhesins are involved in bacterial adhesion to host tissues and mucus during early steps of infection. We report the characterization of BC2L-C, a soluble lectin from the opportunistic pathogen Burkholderia cenocepacia. The N-terminal domain is a novel TNF-a-like fucosebinding lectin, while the C-terminal part is similar to a superfamily of calcium-dependent bacterial lectins. The C-terminal domain displays specificity for mannose and L-glycero-D-manno-heptose. BC2L-C is therefore a superlectin that binds independently to mannose/heptose glycoconjugates and fucosylated human histo-blood group epitopes. We propose that BC2L-C binds to the bacterial surface in a mannose/heptose-dependent manner via the C-terminal domain. The TNF-a-like domain triggers IL-8 production in cultured airway epithelial cells in a carbohydrate-independent manner, and is therefore proposed to play a role in the dysregulated proinflammatory response observed in B. cenocepacia lung infections." . "Marolda, Cristina L" . . . "7" . "Burkholderia cenocepacia BC2L-C Is a Super Lectin with Dual Specificity and Proinflammatory Activity"@en . . "1553-7366" . "14"^^ . . "Valvano, Miguel A" . . . "Burkholderia cenocepacia BC2L-C Is a Super Lectin with Dual Specificity and Proinflammatory Activity" . . . "bacterial lectin; Burkholderia cenocepacia; calcium-dependent bacterial lectins; TNF; inflammation"@en . . . . "Imberty, Anne" . . . "RIV/00216224:14740/11:00050198" . "Chignard, Michel" . "\u0160ul\u00E1k, Ond\u0159ej" . . "000295409000041" . "http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1002238" . "RIV/00216224:14740/11:00050198!RIV12-GA0-14740___" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "9" . "Lectins and adhesins are involved in bacterial adhesion to host tissues and mucus during early steps of infection. We report the characterization of BC2L-C, a soluble lectin from the opportunistic pathogen Burkholderia cenocepacia. The N-terminal domain is a novel TNF-a-like fucosebinding lectin, while the C-terminal part is similar to a superfamily of calcium-dependent bacterial lectins. The C-terminal domain displays specificity for mannose and L-glycero-D-manno-heptose. BC2L-C is therefore a superlectin that binds independently to mannose/heptose glycoconjugates and fucosylated human histo-blood group epitopes. We propose that BC2L-C binds to the bacterial surface in a mannose/heptose-dependent manner via the C-terminal domain. The TNF-a-like domain triggers IL-8 production in cultured airway epithelial cells in a carbohydrate-independent manner, and is therefore proposed to play a role in the dysregulated proinflammatory response observed in B. cenocepacia lung infections."@en . "PLoS Pathogens" . . . "Burkholderia cenocepacia BC2L-C Is a Super Lectin with Dual Specificity and Proinflammatory Activity" . "Wimmerov\u00E1, Michaela" . "10.1371/journal.ppat.1002238" . . "Gutsche, Irina" . . "Malinovsk\u00E1, Lenka" .