. . "Protein arginine methyltransferases (PRMTs) are responsible for symmetric and asymmetric methylation of arginine residues of nuclear and cytoplasmic proteins. In the nucleus, PRMTs belong to important chromatin modifying enzymes of immense functional significance that affect gene expression, splicing and DNA repair. By time-lapse microscopy we have studied the sub-cellular localization and kinetics of PRMT1 after inhibition of PRMT1 and after irradiation. Both transiently expressed and endogenous PRMT1 accumulated in cytoplasmic bodies that were located in the proximity of the cell nucleus. The shape and number of these bodies were stable in untreated cells. However, when cell nuclei were microirradiated by UV-A, the mobility of PRMT1 cytoplasmic bodies increased, size was reduced, and disappeared within approximately 20 min. The same response occurred after gamma-irradiation of the whole cell population, but with delayed kinetics."@en . "Protein arginine methyltransferases (PRMTs) are responsible for symmetric and asymmetric methylation of arginine residues of nuclear and cytoplasmic proteins. In the nucleus, PRMTs belong to important chromatin modifying enzymes of immense functional significance that affect gene expression, splicing and DNA repair. By time-lapse microscopy we have studied the sub-cellular localization and kinetics of PRMT1 after inhibition of PRMT1 and after irradiation. Both transiently expressed and endogenous PRMT1 accumulated in cytoplasmic bodies that were located in the proximity of the cell nucleus. The shape and number of these bodies were stable in untreated cells. However, when cell nuclei were microirradiated by UV-A, the mobility of PRMT1 cytoplasmic bodies increased, size was reduced, and disappeared within approximately 20 min. The same response occurred after gamma-irradiation of the whole cell population, but with delayed kinetics." . "11"^^ . . "Mai, Antonello" . "IT - Italsk\u00E1 republika" . . "Sehnalov\u00E1, Petra" . "PRMT1 arginine methyltransferase accumulates in cytoplasmic bodies that respond to selective inhibition and DNA damage" . "13"^^ . "Sorokin, Dmitry" . . "Legartov\u00E1, So\u0148a" . "PRMT1 arginine methyltransferase accumulates in cytoplasmic bodies that respond to selective inhibition and DNA damage"@en . "Labella, Donatella" . . "P(GBP302/12/G157)" . . "RIV/00216224:14330/14:00073586" . "PRMT1 arginine methyltransferase accumulates in cytoplasmic bodies that respond to selective inhibition and DNA damage" . "Sorokin, Dmitry" . "14330" . "RIV/00216224:14330/14:00073586!RIV15-GA0-14330___" . . "European Journal of Histochemistry" . . . "39655" . "PRMT1 arginine methyltransferase accumulates in cytoplasmic bodies that respond to selective inhibition and DNA damage"@en . . "2" . "10.4081/ejh.2014.2389" . "Eckerich, Carmen" . "58" . "1121-760X" . "[8C944A8DB210]" . . "Kozubek, Stanislav" . "1"^^ . . "Fackelmayer, Frank O." . . "Epigenetics; PRMTs; epi-drugs; arginine methylation; DNA repair"@en . "Such\u00E1nkov\u00E1, Jana" . . "B\u00E1rtov\u00E1, Eva" . "Valente, Sergio" . .