"7"^^ . "000321079400027" . "Stejskal, Stanislav" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "\u0160imara, Pavel" . "Dole\u017Eel, Jan" . . "insulin; dexamethasone; surfactant; lung carcinoma; A549; H441"@en . "1107-3756" . . "10.3892/ijmm.2013.1363" . . . "Coufal, Old\u0159ich" . "http://www.ncbi.nlm.nih.gov/pubmed/23620014" . . "Differential effects of insulin and dexamethasone on pulmonary surfactant-associated genes and proteins in A549 and H441 cells and lung tissue"@en . . . . "14330" . "Differential effects of insulin and dexamethasone on pulmonary surfactant-associated genes and proteins in A549 and H441 cells and lung tissue" . "P(GBP302/12/G157), Z(MSM0021622430)" . "Zvon\u00ED\u010Dek, V\u00E1clav" . "32" . . "Pot\u011B\u0161ilov\u00E1, Michaela" . . "RIV/00216224:14330/13:00066090!RIV14-MSM-14330___" . . . . . . . "RIV/00216224:14330/13:00066090" . "Krontor\u00E1d Koutn\u00E1, Irena" . "Differential effects of insulin and dexamethasone on pulmonary surfactant-associated genes and proteins in A549 and H441 cells and lung tissue"@en . "1" . . . . . "Differential effects of insulin and dexamethasone on pulmonary surfactant-associated genes and proteins in A549 and H441 cells and lung tissue" . . "8"^^ . "Ru\u010Dka, Zden\u011Bk" . . "[33D50BA1B8AF]" . "In this study, the effects of insulin and dexamethasone on the expression and mRNA transcription of 4 pulmonary surfactant-associated proteins [surfactant protein (SFTP)A, SFTPB, SFTPC and SFTPD] were examined. The commercially available cell lines, A549 and H441, were used as acceptable models of lung surfactant-producing cells. Subsequently, the effects of insulin on the expression of surfactant-associated proteins were examined in patients with lung adenocarcinoma during lung resection. Our results demonstrated the inhibitory effects of insulin on the transcription of the SFTPB, SFTPC and SFTPD genes in H441 cells and the SFTPB gene in A549 cells. Treatment with insulin significantly decreased the protein expression of SFTPA1 and SFTPA2 in the H441 cells and that of proSFTPB in the A549 cells."@en . "In this study, the effects of insulin and dexamethasone on the expression and mRNA transcription of 4 pulmonary surfactant-associated proteins [surfactant protein (SFTP)A, SFTPB, SFTPC and SFTPD] were examined. The commercially available cell lines, A549 and H441, were used as acceptable models of lung surfactant-producing cells. Subsequently, the effects of insulin on the expression of surfactant-associated proteins were examined in patients with lung adenocarcinoma during lung resection. Our results demonstrated the inhibitory effects of insulin on the transcription of the SFTPB, SFTPC and SFTPD genes in H441 cells and the SFTPB gene in A549 cells. Treatment with insulin significantly decreased the protein expression of SFTPA1 and SFTPA2 in the H441 cells and that of proSFTPB in the A549 cells." . . "INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE" . "Va\u0148hara, Petr" . . "11"^^ . . "69646" . "\u010Capov, Ivan" . . . "Tesa\u0159ov\u00E1, Lenka" .