"Slab\u00FD, Ond\u0159ej" . "7"^^ . . . "2"^^ . . . "9"^^ . . "RIV/00216224:14330/07:00024059" . "Correlation of selected microRNAs with histopathologic features of colorectal cancer"@en . "Vyzula, Rostislav" . "Zapojen\u00ED vybran\u00FDch mikroRNA do patogeneze kolorekt\u00E1ln\u00EDho karcinomu a jejich korelace s klinicko-patologick\u00FDmi charakteristikami." . . "Svoboda, Miroslav" . "Correlation of selected microRNAs with histopathologic features of colorectal cancer"@en . . "[4C2D5DBA93EE]" . "Svoboda, Marek" . . "MicroRNAs (miRNAs) are noncoding single-strand RNA with a length of 18-25 nucleotides forming a new group of regulators of gene expression occurring in both plant and animal cells. Negatively regulate the mRNA encoding one of two mechanisms depending on the degree of complementarity to the miRNA target sequences. When complete or nearly complete complementarity with the miRNA target sequence is the phenomenon of RNA interference. Coding mRNAs are cleaved ribonuclease in multiproteinov\u00E9m complex associated with miRNAs, RISC (RNA-induced silencing complex), until they are completely degraded. This mechanism has been repeatedly observed in plant cells, but has not yet been demonstrated in animal cells. Animal miRNAs using different mechanism that is associated with degradation of the target mRNA."@en . . "Zapojen\u00ED vybran\u00FDch mikroRNA do patogeneze kolorekt\u00E1ln\u00EDho karcinomu a jejich korelace s klinicko-patologick\u00FDmi charakteristikami."@cs . "Eduka\u010Dn\u00ED sborn\u00EDk. XXXI. Brn\u011Bnsk\u00E9 onkologick\u00E9 dny s XXI. Konferenc\u00ED pro sestry a laboranty." . "14330" . "Masaryk\u016Fv onkologick\u00FD \u00FAstav" . "MikroRNA (miRNA) jsou nek\u00F3duj\u00EDc\u00ED jedno\u0159et\u011Bzcov\u00E9 RNA o d\u00E9lce 18-25 nukleotid\u016F tvo\u0159\u00EDc\u00ED novou skupinu regul\u00E1tor\u016F genov\u00E9 exprese vyskytuj\u00EDc\u00ED se v rostlinn\u00FDch i \u017Eivo\u010Di\u0161n\u00FDch bu\u0148k\u00E1ch. K\u00F3duj\u00EDc\u00ED mRNA negativn\u011B reguluj\u00ED jedn\u00EDm ze dvou mechanizm\u016F v z\u00E1vislosti na m\u00ED\u0159e komplementarity miRNA s c\u00EDlovou sekvenc\u00ED. P\u0159i \u00FApln\u00E9 \u010Di t\u00E9m\u011B\u0159 \u00FApln\u00E9 komplementarit\u011B miRNA s c\u00EDlovou sekvenc\u00ED doch\u00E1z\u00ED k jevu RNA interference. K\u00F3duj\u00EDc\u00ED mRNA jsou \u0161t\u011Bpeny ribonukle\u00E1zami v multiproteinov\u00E9m komplexu asociovan\u00E9m s miRNA, RISC (RNA-induced silencing complex), dokud nejsou zcela degradov\u00E1ny. Tento mechanizmus byl opakovan\u011B pozorov\u00E1n v rostlinn\u00FDch bu\u0148k\u00E1ch, ale doposud nebyl prok\u00E1z\u00E1n u bun\u011Bk \u017Eivo\u010Di\u0161n\u00FDch. \u017Divo\u010Di\u0161n\u00E9 miRNA vyu\u017E\u00EDvaj\u00ED rozd\u00EDln\u00E9ho mechanizmu, kter\u00FD nen\u00ED spojen\u00FD s degradac\u00ED c\u00EDlov\u00E9 mRNA. Regula\u010Dn\u00ED \u00FA\u010Dinek uskute\u010D\u0148uj\u00ED vazbou na nedokonale komplement\u00E1rn\u00ED sekvence v r\u00E1mci 3-netranslatovan\u00FDch oblast\u00ED (UTR) c\u00EDlov\u00FDch mRNA, a expresi gen\u016F reguluj\u00ED post-transkrip\u010Dn\u011B t\u00EDm, \u017Ee znemo\u017E\u0148uj\u00ED jejich translaci."@cs . . . "Trt\u00EDlkov\u00E1, Alena" . "2007-01-01+01:00"^^ . "Zapojen\u00ED vybran\u00FDch mikroRNA do patogeneze kolorekt\u00E1ln\u00EDho karcinomu a jejich korelace s klinicko-patologick\u00FDmi charakteristikami." . "Garajov\u00E1, Ingrid" . . . "RIV/00216224:14330/07:00024059!RIV10-MZ0-14330___" . "Jurasov\u00E1, Ivana" . . "colorectal cancer; patogenesis; microRNA"@en . "Brno" . "\u0160merdov\u00E1, Tamara" . "Brno" . "P(NR9076)" . . . . . "978-978-086-793-5" . "461914" . "Zapojen\u00ED vybran\u00FDch mikroRNA do patogeneze kolorekt\u00E1ln\u00EDho karcinomu a jejich korelace s klinicko-patologick\u00FDmi charakteristikami."@cs . . . "MikroRNA (miRNA) jsou nek\u00F3duj\u00EDc\u00ED jedno\u0159et\u011Bzcov\u00E9 RNA o d\u00E9lce 18-25 nukleotid\u016F tvo\u0159\u00EDc\u00ED novou skupinu regul\u00E1tor\u016F genov\u00E9 exprese vyskytuj\u00EDc\u00ED se v rostlinn\u00FDch i \u017Eivo\u010Di\u0161n\u00FDch bu\u0148k\u00E1ch. K\u00F3duj\u00EDc\u00ED mRNA negativn\u011B reguluj\u00ED jedn\u00EDm ze dvou mechanizm\u016F v z\u00E1vislosti na m\u00ED\u0159e komplementarity miRNA s c\u00EDlovou sekvenc\u00ED. P\u0159i \u00FApln\u00E9 \u010Di t\u00E9m\u011B\u0159 \u00FApln\u00E9 komplementarit\u011B miRNA s c\u00EDlovou sekvenc\u00ED doch\u00E1z\u00ED k jevu RNA interference. K\u00F3duj\u00EDc\u00ED mRNA jsou \u0161t\u011Bpeny ribonukle\u00E1zami v multiproteinov\u00E9m komplexu asociovan\u00E9m s miRNA, RISC (RNA-induced silencing complex), dokud nejsou zcela degradov\u00E1ny. Tento mechanizmus byl opakovan\u011B pozorov\u00E1n v rostlinn\u00FDch bu\u0148k\u00E1ch, ale doposud nebyl prok\u00E1z\u00E1n u bun\u011Bk \u017Eivo\u010Di\u0161n\u00FDch. \u017Divo\u010Di\u0161n\u00E9 miRNA vyu\u017E\u00EDvaj\u00ED rozd\u00EDln\u00E9ho mechanizmu, kter\u00FD nen\u00ED spojen\u00FD s degradac\u00ED c\u00EDlov\u00E9 mRNA. Regula\u010Dn\u00ED \u00FA\u010Dinek uskute\u010D\u0148uj\u00ED vazbou na nedokonale komplement\u00E1rn\u00ED sekvence v r\u00E1mci 3-netranslatovan\u00FDch oblast\u00ED (UTR) c\u00EDlov\u00FDch mRNA, a expresi gen\u016F reguluj\u00ED post-transkrip\u010Dn\u011B t\u00EDm, \u017Ee znemo\u017E\u0148uj\u00ED jejich translaci." . . "\u0160achlov\u00E1, Milana" . .