. "Michalov\u00E1, K." . "Transf\u00FAz. Hemat. dnes" . "47" . "acute lymphoblastic leukemia, infants, t(4:11), fusion gene MLL-AF4"@en . "14330" . . "Jabali, Y." . . "Akutn\u00ED lymfoblastick\u00E1 leuk\u00E9mie u kojenc\u016F" . . . "Mih\u00E1l, V." . "RIV/00216224:14330/02:00012142!RIV/2005/MZ0/143305/N" . "2" . "1"^^ . . . "637743" . . . "Hak, J." . "Akutn\u00ED lymfoblastick\u00E1 leuk\u00E9mie u kojenc\u016F"@cs . . "11"^^ . . "[488C6FB4E556]" . "Bla\u017Eek, B." . "Acute Lymphoblastic Leukemia in Infants"@en . "8"^^ . "Acute Lymphoblastic Leukemia in Infants"@en . "The therapeutic results in children with acute lymphoblastic leukaemia (ALL) are improving continuously with modern treatment protocols of combined chemotherapy. Approximately 75% children and adolescents can be cured from their leukaemia. Among infants younger than one year ALL is a rare disease. Typical infant ALL originates from very early precursors of B cells with a specific genotype, large leukaemic mass on diagnosis and high risk of early relapse. Between 1990-2000, 671 children and adelescents 0-18 years old"@en . "Hrstkov\u00E1, Hana" . "Gajdo\u0161, P." . "Jaro\u0161ov\u00E1, M." . . . . "Hru\u0161\u00E1k, O." . "2002" . . . "CZ - \u010Cesk\u00E1 republika" . "Trka, J." . . "Akutn\u00ED lymfoblastick\u00E1 leuk\u00E9mie u kojenc\u016F" . "P(NC6512), P(NE6406), P(NE6472), Z(MSM 111300001), Z(MSM 111300003), Z(MSM 151100004)" . "RIV/00216224:14330/02:00012142" . "V\u00FDsledky l\u00E9\u010Dby d\u011Btsk\u00E9 akutn\u00ED lymfoblastick\u00E9 leuk\u00E9mie (ALL) se st\u00E1le zlep\u0161uj\u00ED a sou\u010Dasn\u00FDmi protokoly chemoterapie se da\u0159\u00ED vyl\u00E9\u010Dit 75% d\u011Bt\u00ED a dosp\u00EDvaj\u00EDc\u00EDch do 18 let. U kojenc\u016F mlad\u0161\u00EDch jednoho roku se ALL vyskytuje vz\u00E1cn\u011B a je charakterizov\u00E1na imunofenotypem z \u010Dasn\u00FDch stadi\u00ED B lymvocytu, specifick\u00FDm genotypem, velikou n\u00E1dorovou masou p\u0159i diagn\u00F3ze a \u010Dasn\u00FDm relapsem. Z 671 d\u011Bt\u00ED diagnostikovan\u00FDch v \u010Cesk\u00E9 republice s ALL v obdob\u00ED \u010Derven 1990 - prosinec 2000 bylo 24 (3,6%) kojenc\u016F. Chlapci (n=16) m\u011Bli p\u0159evahu nad d\u011Bv\u010Daty (n=8) v pom\u011Bru 2:1, deset d\u011Bt\u00ED bylo mlad\u0161\u00EDch 6 m\u011Bs\u00EDc\u016F. Velmi \u010Dasn\u00FD typ leuk\u00E9mie z B prekurzor\u016F CALLA negativn\u00ED (pro B ALL) m\u011Blo 16 d\u011Bt\u00ED, cALL 7 d\u011Bt\u00ED, T-ALL byla diagnostikov\u00E1na u jednoho pacienta. U 11 d\u011Bt\u00ED (46%) byla nalezena p\u0159i genetick\u00E9m vyy\u0161et\u0159en\u00ED translokace t(4:11)A/nebo f\u00FAzn\u00ED gen MLL-AF4. Patn\u00E1ct d\u011Bt\u00ED bylo l\u00E9\u010Deno podle protokolu ALL-BFM 90, jedno podle ALL-BFM 95, p\u011Bt d\u011Bt\u00ED podle POQ 9407a t\u0159i kojenci podle Interfant 99. V\u00FDsledky l\u00E9\u010Dby byly analyzov\u00E1ny u 21 d\u011Bt\u00ED, proto\u017Ee doba sledov\u00E1"@cs . . "Star\u00FD, J." . . . . "V\u00FDsledky l\u00E9\u010Dby d\u011Btsk\u00E9 akutn\u00ED lymfoblastick\u00E9 leuk\u00E9mie (ALL) se st\u00E1le zlep\u0161uj\u00ED a sou\u010Dasn\u00FDmi protokoly chemoterapie se da\u0159\u00ED vyl\u00E9\u010Dit 75% d\u011Bt\u00ED a dosp\u00EDvaj\u00EDc\u00EDch do 18 let. U kojenc\u016F mlad\u0161\u00EDch jednoho roku se ALL vyskytuje vz\u00E1cn\u011B a je charakterizov\u00E1na imunofenotypem z \u010Dasn\u00FDch stadi\u00ED B lymvocytu, specifick\u00FDm genotypem, velikou n\u00E1dorovou masou p\u0159i diagn\u00F3ze a \u010Dasn\u00FDm relapsem. Z 671 d\u011Bt\u00ED diagnostikovan\u00FDch v \u010Cesk\u00E9 republice s ALL v obdob\u00ED \u010Derven 1990 - prosinec 2000 bylo 24 (3,6%) kojenc\u016F. Chlapci (n=16) m\u011Bli p\u0159evahu nad d\u011Bv\u010Daty (n=8) v pom\u011Bru 2:1, deset d\u011Bt\u00ED bylo mlad\u0161\u00EDch 6 m\u011Bs\u00EDc\u016F. Velmi \u010Dasn\u00FD typ leuk\u00E9mie z B prekurzor\u016F CALLA negativn\u00ED (pro B ALL) m\u011Blo 16 d\u011Bt\u00ED, cALL 7 d\u011Bt\u00ED, T-ALL byla diagnostikov\u00E1na u jednoho pacienta. U 11 d\u011Bt\u00ED (46%) byla nalezena p\u0159i genetick\u00E9m vyy\u0161et\u0159en\u00ED translokace t(4:11)A/nebo f\u00FAzn\u00ED gen MLL-AF4. Patn\u00E1ct d\u011Bt\u00ED bylo l\u00E9\u010Deno podle protokolu ALL-BFM 90, jedno podle ALL-BFM 95, p\u011Bt d\u011Bt\u00ED podle POQ 9407a t\u0159i kojenci podle Interfant 99. V\u00FDsledky l\u00E9\u010Dby byly analyzov\u00E1ny u 21 d\u011Bt\u00ED, proto\u017Ee doba sledov\u00E1" . . "Akutn\u00ED lymfoblastick\u00E1 leuk\u00E9mie u kojenc\u016F"@cs .