. "406" . "5"^^ . "LC-MS/MS determination of potential endocrine disruptors of cortico signalling in rivers and wastewaters"@en . . . . "RIV/00216224:14310/14:00079393" . "13"^^ . "LC-MS/MS determination of potential endocrine disruptors of cortico signalling in rivers and wastewaters"@en . "000344860300024" . "A targeted analytical method was established to determine a large number of chemicals known to interfere with the gluco- and mineralocorticoid signalling pathway. The analytes comprise 30 glucocorticoids and 9 mineralocorticoids. Ten out of these corticosteroids were primary metabolites. Additionally, 14 nonsteroids were included. These analytes represent a broader range of possible adverse modes of action than previously reported. For the simultaneous determination of these structurally diverse compounds, a single-step multimode solid-phase extraction and pre-concentration was applied. Extracts were separated by a short linear HPLC gradient (20 min) on a core shell RP column (2.7 mu m particle size) and compounds identified and quantified by LC-MS/MS. The method provided excellent retention time reproducibility and detection limits in the low nanograms per litre range." . . . "LC-MS/MS determination of potential endocrine disruptors of cortico signalling in rivers and wastewaters" . "14310" . "RIV/00216224:14310/14:00079393!RIV15-MSM-14310___" . "10.1007/s00216-014-8206-9" . "1"^^ . . "A targeted analytical method was established to determine a large number of chemicals known to interfere with the gluco- and mineralocorticoid signalling pathway. The analytes comprise 30 glucocorticoids and 9 mineralocorticoids. Ten out of these corticosteroids were primary metabolites. Additionally, 14 nonsteroids were included. These analytes represent a broader range of possible adverse modes of action than previously reported. For the simultaneous determination of these structurally diverse compounds, a single-step multimode solid-phase extraction and pre-concentration was applied. Extracts were separated by a short linear HPLC gradient (20 min) on a core shell RP column (2.7 mu m particle size) and compounds identified and quantified by LC-MS/MS. The method provided excellent retention time reproducibility and detection limits in the low nanograms per litre range."@en . . . "Ammann, Adrian A." . "LC-MS/MS determination of potential endocrine disruptors of cortico signalling in rivers and wastewaters" . "Mac\u00EDkov\u00E1, Petra" . "I, S" . "Analytical and Bioanalytical chemistry" . "Suter, Marc J.F." . "Groh, Ksenia J." . . "Environmental endocrine disruptors; Corticosteroid signalling pathway; Pharmaceuticals; Metabolites; Surface water"@en . "1618-2642" . "25798" . . . . . "http://link.springer.com/article/10.1007%2Fs00216-014-8206-9" . . "DE - Spolkov\u00E1 republika N\u011Bmecko" . "29" . . "Schirmer, Kristin" . "[5E43DD66F616]" . .