"7" . . . "1936-2625" . "6"^^ . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "Genome-wide screening of DNA copy number alterations in cervical carcinoma patients with CGH+SNP microarrays and HPV-FISH"@en . "Cervical carcinoma; whole-genome profiling; CGH+SNP microarrays; HPV-FISH; copy number alterations"@en . . "8" . . . "[EAB87DB267B9]" . . "Bro\u017Eov\u00E1, Lucie" . . "Cvanov\u00E1, Michaela" . "14310" . . "Vallov\u00E1, Vladim\u00EDra" . . "RIV/00216224:14310/14:00078290!RIV15-MSM-14310___" . . . . "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152070" . . "RIV/00216224:14310/14:00078290" . . . "Genome-wide screening of DNA copy number alterations in cervical carcinoma patients with CGH+SNP microarrays and HPV-FISH" . "International Journal of Clinical and Experimental Pathology" . . "P(EE2.3.20.0183), P(NT11089), S" . "000345120900052" . "Genome-wide screening of DNA copy number alterations in cervical carcinoma patients with CGH+SNP microarrays and HPV-FISH"@en . "12"^^ . . "Genome-wide screening of DNA copy number alterations in cervical carcinoma patients with CGH+SNP microarrays and HPV-FISH" . . "Kugl\u00EDk, Petr" . "Alterations in the genome that lead to changes in DNA sequence copy number are characteristic features of solid tumors. We used CGH+SNP microarray and HPV-FISH techniques for detailed screening of copy number alterations (CNAs) in a cohort of 26 patients with cervical carcinoma (CC). This approach identified CNAs in 96.2% (25/26) of tumors. Array-CGH discovered CNAs in 73.1% (19/26) of samples, HPV-FISH experiments revealed CNAs in additional 23.1% (6/26) of samples. Common gains of genetic sequences were observed in 3q (50.0%), 1q (42.4%), 19q (23.1%), while losses were frequently found in 11q (30.8%), 4q (23.1%) and 13q (19.2%). Chromosomal regions involved in loss of heterozygosity were observed in 15.4% of samples in 8q21, 11q23, 14q21 and 18q12.2. Incidence of gain 3q was associated with HPV 16 and HPV 18 positive samples and simultaneous presence of gain 1q (P = 0.033)."@en . "Alterations in the genome that lead to changes in DNA sequence copy number are characteristic features of solid tumors. We used CGH+SNP microarray and HPV-FISH techniques for detailed screening of copy number alterations (CNAs) in a cohort of 26 patients with cervical carcinoma (CC). This approach identified CNAs in 96.2% (25/26) of tumors. Array-CGH discovered CNAs in 73.1% (19/26) of samples, HPV-FISH experiments revealed CNAs in additional 23.1% (6/26) of samples. Common gains of genetic sequences were observed in 3q (50.0%), 1q (42.4%), 19q (23.1%), while losses were frequently found in 11q (30.8%), 4q (23.1%) and 13q (19.2%). Chromosomal regions involved in loss of heterozygosity were observed in 15.4% of samples in 8q21, 11q23, 14q21 and 18q12.2. Incidence of gain 3q was associated with HPV 16 and HPV 18 positive samples and simultaneous presence of gain 1q (P = 0.033)." . . "7"^^ . . "Ka\u0161\u00EDkov\u00E1, Kate\u0159ina" . . "Smetana, Jan" . "Moukov\u00E1, Lucie" . . . "18148" . .