. . . "Mo\u017Enosti studia transendoteli\u00E1ln\u00ED migrace in vitro" . "3"^^ . . . . . "2"^^ . "transendothelial migration; extravasation; endothelial cells; metastasis; transwell system"@en . . "0862-495X" . "Mo\u017Enosti studia transendoteli\u00E1ln\u00ED migrace in vitro"@cs . "1" . "Mo\u017Enosti studia transendoteli\u00E1ln\u00ED migrace in vitro" . . "Mo\u017Enosti studia transendoteli\u00E1ln\u00ED migrace in vitro"@cs . "P(ED2.1.00/03.0101), S" . "RIV/00216224:14310/14:00075852" . "27" . . "CZ - \u010Cesk\u00E1 republika" . . . . "Knopfov\u00E1, Lucia" . . "Klinick\u00E1 onkologie" . . . "Nejz\u00E1va\u017En\u011Bj\u0161\u00ED komplikac\u00ED n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED je vznik vzd\u00E1len\u00FDch metast\u00E1z. K \u0161\u00ED\u0159en\u00ED do vzd\u00E1len\u00FDch org\u00E1n\u016F vyu\u017E\u00EDvaj\u00ED n\u00E1dorov\u00E9 bu\u0148ky \u010Dasto krevn\u00ED cirkulaci. Vstup do krevn\u00EDho ob\u011Bhu a pr\u016Fchod st\u011Bnou kapil\u00E1ry do c\u00EDlov\u00E9ho sekund\u00E1rn\u00EDho m\u00EDsta umo\u017E\u0148uj\u00ED kolonizaci jin\u00FDch org\u00E1n\u016F a vznik \u017Eivot ohro\u017Euj\u00EDc\u00EDch metast\u00E1z. Pr\u016Fchod st\u011Bnou c\u00E9vy (transendoteli\u00E1ln\u00ED migrace) je z\u00E1sadn\u00ED krok metastatick\u00E9 kask\u00E1dy.Existuje n\u011Bkolik zp\u016Fsob\u016F, jak studovat transendoteli\u00E1ln\u00ED migraci v \u017Eiv\u00FDch modelov\u00FDch organizmech. Jejich v\u00FDhodou je, \u017Ee poskytuj\u00ED komplexn\u00ED fyziologick\u00E9 mikroprost\u0159ed\u00ED, jsou ale n\u00E1kladn\u00E9 a technicky n\u00E1ro\u010Dn\u00E9. Proto se pou\u017E\u00EDvaj\u00ED st\u00E1le dokonalej\u0161\u00ED techniky pro sledov\u00E1n\u00ED transendoteli\u00E1ln\u00ED migrace in vitro, kter\u00E9 jsou obecn\u011B dostupn\u011Bj\u0161\u00ED a m\u00E9n\u011B n\u00E1ro\u010Dn\u00E9 na vybaven\u00ED. Technick\u00E9 p\u0159\u00EDstupy ke studiu transendoteli\u00E1ln\u00ED migrace in vitro, jejich rozd\u011Blen\u00ED, modifikace, v\u00FDhody a nev\u00FDhody jsou p\u0159edm\u011Btem tohoto p\u0159ehledov\u00E9ho \u010Dl\u00E1nku." . "30807" . "[96FA60E0FD29]" . "Bouchal, Pavel" . "The most dangerous aspect of cancer is the metastatic spread to other parts of the body. Cancer cells frequently use circulation to spread to secondary locations. By entering the bloodstream (in a process called intravasation) and by crossing the vessel walls at the metastatic sites (extravasation) tumor cells disseminate to distal organs and eventually form life-threatening metastases. Crossing the vessel walls (transendothelial migration) is a vital step of metastatic cascade. There are several methods to study transendothelial migration in living models. Although they offer complex physiological microenvironment, they are expensive and technically demanding, therefore not widely used. As an alternative, sophisticated techniques to investigate transendothelial migration in vitro have been developed. Classification, modifications, pros and cons of the in vitro techniques for studying transendothelial migration are summarized in this review."@en . "Techniques to Study Transendothelial Migration In Vitro"@en . . "Nejz\u00E1va\u017En\u011Bj\u0161\u00ED komplikac\u00ED n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED je vznik vzd\u00E1len\u00FDch metast\u00E1z. K \u0161\u00ED\u0159en\u00ED do vzd\u00E1len\u00FDch org\u00E1n\u016F vyu\u017E\u00EDvaj\u00ED n\u00E1dorov\u00E9 bu\u0148ky \u010Dasto krevn\u00ED cirkulaci. Vstup do krevn\u00EDho ob\u011Bhu a pr\u016Fchod st\u011Bnou kapil\u00E1ry do c\u00EDlov\u00E9ho sekund\u00E1rn\u00EDho m\u00EDsta umo\u017E\u0148uj\u00ED kolonizaci jin\u00FDch org\u00E1n\u016F a vznik \u017Eivot ohro\u017Euj\u00EDc\u00EDch metast\u00E1z. Pr\u016Fchod st\u011Bnou c\u00E9vy (transendoteli\u00E1ln\u00ED migrace) je z\u00E1sadn\u00ED krok metastatick\u00E9 kask\u00E1dy.Existuje n\u011Bkolik zp\u016Fsob\u016F, jak studovat transendoteli\u00E1ln\u00ED migraci v \u017Eiv\u00FDch modelov\u00FDch organizmech. Jejich v\u00FDhodou je, \u017Ee poskytuj\u00ED komplexn\u00ED fyziologick\u00E9 mikroprost\u0159ed\u00ED, jsou ale n\u00E1kladn\u00E9 a technicky n\u00E1ro\u010Dn\u00E9. Proto se pou\u017E\u00EDvaj\u00ED st\u00E1le dokonalej\u0161\u00ED techniky pro sledov\u00E1n\u00ED transendoteli\u00E1ln\u00ED migrace in vitro, kter\u00E9 jsou obecn\u011B dostupn\u011Bj\u0161\u00ED a m\u00E9n\u011B n\u00E1ro\u010Dn\u00E9 na vybaven\u00ED. Technick\u00E9 p\u0159\u00EDstupy ke studiu transendoteli\u00E1ln\u00ED migrace in vitro, jejich rozd\u011Blen\u00ED, modifikace, v\u00FDhody a nev\u00FDhody jsou p\u0159edm\u011Btem tohoto p\u0159ehledov\u00E9ho \u010Dl\u00E1nku."@cs . "\u0160marda, Jan" . "6"^^ . "Techniques to Study Transendothelial Migration In Vitro"@en . . . "14310" . "RIV/00216224:14310/14:00075852!RIV15-MSM-14310___" .