"52316" . "P(ED2.1.00/03.0086), Z(MSM0021622411)" . . "Use of nanomaterials for TOF mass spectrometry of complex biomolecules and for tissue profiling"@en . "Puig Romero, Mireia" . . . . . "Kol\u00E1\u0159ov\u00E1, Lenka" . . "Va\u0148hara, Petr" . . "Hampl, Ale\u0161" . . "RIV/00216224:14310/14:00075127" . . "Use of nanomaterials for TOF mass spectrometry of complex biomolecules and for tissue profiling"@en . "Salvado, Victoria" . "Mass spectrometry (MS) of complex biomolecules is mostly performed using Matrix-Assisted Laser Desorption Ionization (MALDI) with Time of Flight (TOF) detection. Development of nanotechnology and nanomaterials (NMs) and nanoparticles (NPs) with their unique physical and chemical properties brought to MS alternative media for efficient ionization of analytes and accelerated development of Surface-Assisted Laser Desorption Ionization (SALDI), Surface-Enhanced Laser Desorption Ionization (SELDI) and Nano-Assisted Laser Desorption Ionization (NALDI). These techniques contributed significantly to MS [1]. NMs possess also extensive applications in MALDI TOF MS tissue imaging in current nanomedicine [2]. In this work, we studied applications of various NMs (either as matrices or surfaces) in MS analysis of histological tissue sections. We also evaluated effect of NMs on the ionization of various peptides and the comparison with common organic matrices was done." . "Mass spectrometry (MS) of complex biomolecules is mostly performed using Matrix-Assisted Laser Desorption Ionization (MALDI) with Time of Flight (TOF) detection. Development of nanotechnology and nanomaterials (NMs) and nanoparticles (NPs) with their unique physical and chemical properties brought to MS alternative media for efficient ionization of analytes and accelerated development of Surface-Assisted Laser Desorption Ionization (SALDI), Surface-Enhanced Laser Desorption Ionization (SELDI) and Nano-Assisted Laser Desorption Ionization (NALDI). These techniques contributed significantly to MS [1]. NMs possess also extensive applications in MALDI TOF MS tissue imaging in current nanomedicine [2]. In this work, we studied applications of various NMs (either as matrices or surfaces) in MS analysis of histological tissue sections. We also evaluated effect of NMs on the ionization of various peptides and the comparison with common organic matrices was done."@en . . "4"^^ . . "RIV/00216224:14310/14:00075127!RIV15-MSM-14310___" . . . . "14310" . . . "MALDI MS; Nanotechnology; Nanoparticles; Nanoflowers; Tissue profiling"@en . . . "[63C61AC4123C]" . "Havel, Josef" . . "Use of nanomaterials for TOF mass spectrometry of complex biomolecules and for tissue profiling" . "6"^^ . . "Use of nanomaterials for TOF mass spectrometry of complex biomolecules and for tissue profiling" . . .