"RIV/00216224:14310/14:00074125" . . "34" . "Bryja, V\u00EDt\u011Bzslav" . . "Zdr\u00E1hal, Zbyn\u011Bk" . . . "14310" . . . "289" . "Ganji, Sri Ranjani" . . . . . . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "Functional Analysis of Dishevelled-3 Phosphorylation Identifies Distinct Mechanisms Driven by Casein Kinase 1 epsilon and Frizzled5" . . "14"^^ . "Journal of Biological Chemistry" . "000341505000023" . . . . "Ganji, Sri Ranjani" . "[92A11916B5B9]" . "Functional Analysis of Dishevelled-3 Phosphorylation Identifies Distinct Mechanisms Driven by Casein Kinase 1 epsilon and Frizzled5"@en . "Functional Analysis of Dishevelled-3 Phosphorylation Identifies Distinct Mechanisms Driven by Casein Kinase 1 epsilon and Frizzled5" . . "RIV/00216224:14310/14:00074125!RIV15-MSM-14310___" . "17651" . . . . "Schille, Carolin" . . . . "Schambony, Alexandra" . "Trant\u00EDrek, Luk\u00E1\u0161" . . "0021-9258" . "Bernat\u00EDk, Ond\u0159ej" . . "\u010Cervenka, Igor" . "Background: Phosphorylation of Dishevelled (Dvl) by casein kinase 1E (CK1E) is a key event in Wnt signal transduction. Results: Dvl3 residues phosphorylated by CK1E were identified by proteomics and analyzed functionally. Conclusion: Individual phosphorylation events control different aspects of Dvl biology. Significance: CK1E and Fzd5, a Wnt receptor, act on Dvl via distinct mechanism, suggesting that CK1E is not directly downstream of Frizzled5. Dishevelled-3 (Dvl3), a key component of the Wnt signaling pathways, acts downstream of Frizzled (Fzd) receptors and gets heavily phosphorylated in response to pathway activation by Wnt ligands. Casein kinase 1E (CK1E) was identified as the major kinase responsible for Wnt-induced Dvl3 phosphorylation. Currently it is not clear which Dvl residues are phosphorylated and what is the consequence of individual phosphorylation events." . "PLANAR CELL POLARITY; BETA-CATENIN; WNT/BETA-CATENIN; PDZ DOMAIN; I-EPSILON; WNT PATHWAY; PROTEIN; DROSOPHILA; DVL; FAMILY"@en . "9"^^ . . . . "\u0160edov\u00E1, Kate\u0159ina" . . "7"^^ . . . . "Functional Analysis of Dishevelled-3 Phosphorylation Identifies Distinct Mechanisms Driven by Casein Kinase 1 epsilon and Frizzled5"@en . "http://www.ncbi.nlm.nih.gov/pubmed/24993822" . . "Background: Phosphorylation of Dishevelled (Dvl) by casein kinase 1E (CK1E) is a key event in Wnt signal transduction. Results: Dvl3 residues phosphorylated by CK1E were identified by proteomics and analyzed functionally. Conclusion: Individual phosphorylation events control different aspects of Dvl biology. Significance: CK1E and Fzd5, a Wnt receptor, act on Dvl via distinct mechanism, suggesting that CK1E is not directly downstream of Frizzled5. Dishevelled-3 (Dvl3), a key component of the Wnt signaling pathways, acts downstream of Frizzled (Fzd) receptors and gets heavily phosphorylated in response to pathway activation by Wnt ligands. Casein kinase 1E (CK1E) was identified as the major kinase responsible for Wnt-induced Dvl3 phosphorylation. Currently it is not clear which Dvl residues are phosphorylated and what is the consequence of individual phosphorylation events."@en . . "10.1074/jbc.M114.590638" . "I, P(ED1.1.00/02.0068), P(EE2.3.20.0042), P(GA204/09/0498), P(GP13-31488P), P(LM2011020), S, Z(MSM0021622430)" .