"Molecular mechanisms of ncRNA transcription processes"@en . "RIV/00216224:14310/13:00065586" . "\u0160er\u00FD, Omar" . . . "Molekul\u00E1rn\u00ED mechanismy transkrip\u010Dn\u00EDch proces\u016F ncRNA" . "Recently 2nd generation sequenators helped to discover that 90% of genomic DNA is transcribed into RNA from which protein coding RNA account for about 1-2% while the rest is so ncRNA. This could answer the question asked by molecular biologists in 21. century: \u201EWhat is the purpose of nonsense non-coding genomic DNA?%22 Non-coding RNA (ncRNA) is transcribed much less in comparison to messenger RNA (mRNA) and has rather regulatory function. ncRNAs can be devided to infrastructural ncRNA and regulatory ncRNA. Among infrastructural ncRNA belongs ribosomal (rRNAs), transfer (tRNA), small nucluar RNA (snRNA) and small nucleolar RNA (snoRNAs). Among regulatory ncRNA belongs microRNA (miRNAs), Piwi-interacting RNA (piRNAs), small interfering RNA (siRNAs) and long non-coding RNA (lncRNAs). In addation to these there have been discovered also promoter-associated RNA (PARs) and enhancer RNA (eRNAs)."@en . "V sou\u010Dasn\u00E9 dob\u011B bylo pomoc\u00ED technologi\u00ED sekven\u00E1tor\u016F II. generace p\u0159ekvapiv\u011B zji\u0161t\u011Bno, \u017Ee a\u017E 90% genomick\u00E9 DNA je p\u0159episov\u00E1no do RNA, z \u010Deho\u017E pouze 1-2% je RNA k\u00F3duj\u00EDc\u00ED proteiny a zbytek je tzv. ncRNA. Postupn\u011B se odhaluje odpov\u011B\u010F na z\u00E1sadn\u00ED ot\u00E1zku polo\u017Eenou molekul\u00E1rn\u00EDmi biology ve dvac\u00E1t\u00E9m stolet\u00ED: \u201EK \u010Demu je v genomu nesmysln\u00E1 DNA, kter\u00E1 nek\u00F3duje \u017E\u00E1dn\u00E9 proteiny?\u201C. Nek\u00F3duj\u00EDc\u00ED RNA (non-coding RNA, ncRNA) se p\u0159episuje v mnohem men\u0161\u00EDm mno\u017Estv\u00ED ne\u017E b\u011B\u017En\u00E1 medi\u00E1torov\u00E1 RNA (mRNA) a m\u00E1 sp\u00ED\u0161e regula\u010Dn\u00ED \u00FAlohu. ncRNA d\u011Bl\u00EDme na infrastruktur\u00E1ln\u00ED ncRNA a regula\u010Dn\u00ED ncRNA. Infrastruktur\u00E1ln\u00ED ncRNA zahrnuje ribozom\u00E1ln\u00ED (rRNAs), transferovou (tRNA), malou jadernou a malou jad\u00E9rkovou RNA (snoRNAs). Mezi regula\u010Dn\u00ED ncRNA pat\u0159\u00ED microRNA (miRNAs), Piwi-interaguj\u00EDc\u00ED RNA (piRNAs), mal\u00E9 interferuj\u00EDc\u00ED RNA (siRNAs) a dlouh\u00E9 nek\u00F3duj\u00EDc\u00ED RNA (lncRNAs). Krom\u011B toho byly nov\u011B objeveny tak\u00E9 s promotorem asociovan\u00E9 RNA (PARs) a enhancerov\u00E9 RNA (eRNAs)."@cs . "V sou\u010Dasn\u00E9 dob\u011B bylo pomoc\u00ED technologi\u00ED sekven\u00E1tor\u016F II. generace p\u0159ekvapiv\u011B zji\u0161t\u011Bno, \u017Ee a\u017E 90% genomick\u00E9 DNA je p\u0159episov\u00E1no do RNA, z \u010Deho\u017E pouze 1-2% je RNA k\u00F3duj\u00EDc\u00ED proteiny a zbytek je tzv. ncRNA. Postupn\u011B se odhaluje odpov\u011B\u010F na z\u00E1sadn\u00ED ot\u00E1zku polo\u017Eenou molekul\u00E1rn\u00EDmi biology ve dvac\u00E1t\u00E9m stolet\u00ED: \u201EK \u010Demu je v genomu nesmysln\u00E1 DNA, kter\u00E1 nek\u00F3duje \u017E\u00E1dn\u00E9 proteiny?\u201C. Nek\u00F3duj\u00EDc\u00ED RNA (non-coding RNA, ncRNA) se p\u0159episuje v mnohem men\u0161\u00EDm mno\u017Estv\u00ED ne\u017E b\u011B\u017En\u00E1 medi\u00E1torov\u00E1 RNA (mRNA) a m\u00E1 sp\u00ED\u0161e regula\u010Dn\u00ED \u00FAlohu. ncRNA d\u011Bl\u00EDme na infrastruktur\u00E1ln\u00ED ncRNA a regula\u010Dn\u00ED ncRNA. Infrastruktur\u00E1ln\u00ED ncRNA zahrnuje ribozom\u00E1ln\u00ED (rRNAs), transferovou (tRNA), malou jadernou a malou jad\u00E9rkovou RNA (snoRNAs). Mezi regula\u010Dn\u00ED ncRNA pat\u0159\u00ED microRNA (miRNAs), Piwi-interaguj\u00EDc\u00ED RNA (piRNAs), mal\u00E9 interferuj\u00EDc\u00ED RNA (siRNAs) a dlouh\u00E9 nek\u00F3duj\u00EDc\u00ED RNA (lncRNAs). Krom\u011B toho byly nov\u011B objeveny tak\u00E9 s promotorem asociovan\u00E9 RNA (PARs) a enhancerov\u00E9 RNA (eRNAs)." . "1"^^ . . . "Molekul\u00E1rn\u00ED mechanismy transkrip\u010Dn\u00EDch proces\u016F ncRNA" . . . . "P(NT11152)" . . . "Molekul\u00E1rn\u00ED mechanismy transkrip\u010Dn\u00EDch proces\u016F ncRNA"@cs . "Molekul\u00E1rn\u00ED mechanismy transkrip\u010Dn\u00EDch proces\u016F ncRNA"@cs . . "1"^^ . . "14310" . . . "Molecular mechanisms of ncRNA transcription processes"@en . "ncRNA; psychological disorders; transcriptional processes"@en . "RIV/00216224:14310/13:00065586!RIV14-MZ0-14310___" . . . "89350" . "[ECE1E99241F9]" . .