. "Molecular genetics of Alzheimer's disease - the pathway to personalized diagnostics and treatment"@en . . "Molekul\u00E1rn\u00ED genetika Alzheimerovy choroby \u2013 cesta k personalizovan\u00E9 diagnostice a l\u00E9\u010Db\u011B"@cs . "Molekul\u00E1rn\u00ED genetika Alzheimerovy choroby \u2013 cesta k personalizovan\u00E9 diagnostice a l\u00E9\u010Db\u011B" . . "[2BD71FEA9F1B]" . . . . . "1"^^ . "RIV/00216224:14310/13:00065585" . "P(NT11152)" . "14310" . . . "RIV/00216224:14310/13:00065585!RIV14-MZ0-14310___" . "Alzheimer disease; Abeta protein; microarray technology"@en . "Molekul\u00E1rn\u00ED genetika Alzheimerovy choroby \u2013 cesta k personalizovan\u00E9 diagnostice a l\u00E9\u010Db\u011B"@cs . "89347" . "Molekul\u00E1rn\u00ED genetika Alzheimerovy choroby \u2013 cesta k personalizovan\u00E9 diagnostice a l\u00E9\u010Db\u011B" . . "Molecular genetics of Alzheimer's disease - the pathway to personalized diagnostics and treatment"@en . . "Poznatky o molekul\u00E1rn\u00ED podstat\u011B Alzheimerovy choroby se v posledn\u00EDch letech neb\u00FDvale rozrostly. Sou\u010Dasn\u00E9 mo\u017Enosti DNA \u010Dipov\u00FDch technologi\u00ED a sekvenov\u00E1n\u00ED II. generace umo\u017Enily prudk\u00FD rozvoj poznatk\u016F. Byla prok\u00E1z\u00E1na souvislost mezi des\u00EDtkami gen\u016F a patogenez\u00ED AD, byly vysloveny nov\u00E9 teorie vysv\u011Btluj\u00EDc\u00ED patogenezi AD. Cesty \u0161t\u011Bpen\u00ED proteinu Abeta sekret\u00E1zami byly podrobn\u011B pops\u00E1ny a prozkoum\u00E1ny i z hlediska mo\u017Enost\u00ED farmakologick\u00E9ho z\u00E1sahu. Vliv transportu mitochondri\u00ED v bu\u0148ce, stejn\u011B jako vliv mikrokrv\u00E1cen\u00ED se popisuj\u00ED jako mo\u017En\u00E9 p\u0159\u00ED\u010Diny vedouc\u00ED ke vzniku AD. Mezi posledn\u00ED teorie vzniku AD pat\u0159\u00ED vliv nek\u00F3duj\u00EDc\u00EDch mikro RNA (miRNA) na koncentraci prote\u00E1z \u0161t\u011Bp\u00EDc\u00EDch Abeta protein. Jak se ukazuje, vliv apolipoproteinu E a jeho genotyp\u016F je st\u00E1le zcela z\u00E1sadn\u00ED tak\u00E9 v \u010Desk\u00E9 populaci. Sou\u010Dasn\u00FD systematick\u00FD v\u00FDzkum za vyu\u017Eit\u00ED DNA \u010Dipov\u00E9 technologie zam\u011B\u0159en\u00FD na studium epidemiologick\u00FDch dat, rodinn\u00FDch a osobn\u00EDch anamn\u00E9z osob trp\u00EDc\u00EDch AD p\u0159inese v p\u0159\u00ED\u0161t\u00EDch letech nov\u00E9 mo\u017Enosti personalizovan\u00E9 diagnostiky a l\u00E9\u010Dby."@cs . "1"^^ . . "\u0160er\u00FD, Omar" . . . "Findings about molecular basis of Alzheimer's disease expanded in recent years due to possibilities of new microarray technology and 2nd generation sequencing. There have been proved correlation of number of genes with AD pathogenesis. New theories have been introduced explaining this AD pathogenesis. Abeta cleaving pathways have been thoroughly described also with the possibility of pharmacological impact. Mitochondrial trafficking in cell, microvascular bleeding are thought to be involved in AD development. One of the most recent theories of AD development suggest the involvement non-coding micro RNA (miRNA) in the concentration changes of proteases cleaving Abeta. Despite this there still remains the evidence of apolipoprotein E genotypes to be crucial in czech population.Use of microarray technology for systematical studying of epidemiological data, familial and personal anamnesis of those individuals having AD willl hopefuly allow in following years more personalized diagnotics and treatmant."@en . "Poznatky o molekul\u00E1rn\u00ED podstat\u011B Alzheimerovy choroby se v posledn\u00EDch letech neb\u00FDvale rozrostly. Sou\u010Dasn\u00E9 mo\u017Enosti DNA \u010Dipov\u00FDch technologi\u00ED a sekvenov\u00E1n\u00ED II. generace umo\u017Enily prudk\u00FD rozvoj poznatk\u016F. Byla prok\u00E1z\u00E1na souvislost mezi des\u00EDtkami gen\u016F a patogenez\u00ED AD, byly vysloveny nov\u00E9 teorie vysv\u011Btluj\u00EDc\u00ED patogenezi AD. Cesty \u0161t\u011Bpen\u00ED proteinu Abeta sekret\u00E1zami byly podrobn\u011B pops\u00E1ny a prozkoum\u00E1ny i z hlediska mo\u017Enost\u00ED farmakologick\u00E9ho z\u00E1sahu. Vliv transportu mitochondri\u00ED v bu\u0148ce, stejn\u011B jako vliv mikrokrv\u00E1cen\u00ED se popisuj\u00ED jako mo\u017En\u00E9 p\u0159\u00ED\u010Diny vedouc\u00ED ke vzniku AD. Mezi posledn\u00ED teorie vzniku AD pat\u0159\u00ED vliv nek\u00F3duj\u00EDc\u00EDch mikro RNA (miRNA) na koncentraci prote\u00E1z \u0161t\u011Bp\u00EDc\u00EDch Abeta protein. Jak se ukazuje, vliv apolipoproteinu E a jeho genotyp\u016F je st\u00E1le zcela z\u00E1sadn\u00ED tak\u00E9 v \u010Desk\u00E9 populaci. Sou\u010Dasn\u00FD systematick\u00FD v\u00FDzkum za vyu\u017Eit\u00ED DNA \u010Dipov\u00E9 technologie zam\u011B\u0159en\u00FD na studium epidemiologick\u00FDch dat, rodinn\u00FDch a osobn\u00EDch anamn\u00E9z osob trp\u00EDc\u00EDch AD p\u0159inese v p\u0159\u00ED\u0161t\u00EDch letech nov\u00E9 mo\u017Enosti personalizovan\u00E9 diagnostiky a l\u00E9\u010Dby." . . .