. . "Eckschlager, Tom\u00E1\u0161" . "17"^^ . . "Trnkov\u00E1, Libu\u0161e" . "An Adsorptive Transfer Technique Coupled with Brdicka Reaction to Reveal the Importance of Metallothionein in Chemotherapy with Platinum Based Cytostatics"@en . . "10.3390/ijms11124826" . . . "The drugs based on platinum metals represent one of the oldest, but also one of the most effective groups of chemotherapeutic agents. Thanks to many clinical studies it is known that resistance of tumor cells to drugs is a frequent cause of chemotherapy failure. With regard to platinum based drugs, multidrug resistance can also be connected with increased expression of low-molecular weight protein metallothionein (MT). This study aimed at investigating the interactions of MT with cisplatin or carboplatin, using the adsorptive transfer technique coupled with differential pulse voltammetry Brdicka reaction (AdTS DPV Brdicka reaction), and a comparison of in vitro results with results obtained in vivo. The results obtained from the in vitro study show a strong affinity between platinum based drugs and MT. Further, we analyzed extracts of neuroblastoma cell lines treated with cisplatin or carboplatin."@en . "Pochop, Jan" . . "K\u0159\u00ED\u017Ekov\u00E1, So\u0148a" . "Hrab\u011Bta, Jan" . . "Pr\u016F\u0161a, Richard" . "[8DB725A769F9]" . "Kizek, Ren\u00E9" . . "The drugs based on platinum metals represent one of the oldest, but also one of the most effective groups of chemotherapeutic agents. Thanks to many clinical studies it is known that resistance of tumor cells to drugs is a frequent cause of chemotherapy failure. With regard to platinum based drugs, multidrug resistance can also be connected with increased expression of low-molecular weight protein metallothionein (MT). This study aimed at investigating the interactions of MT with cisplatin or carboplatin, using the adsorptive transfer technique coupled with differential pulse voltammetry Brdicka reaction (AdTS DPV Brdicka reaction), and a comparison of in vitro results with results obtained in vivo. The results obtained from the in vitro study show a strong affinity between platinum based drugs and MT. Further, we analyzed extracts of neuroblastoma cell lines treated with cisplatin or carboplatin." . . "An Adsorptive Transfer Technique Coupled with Brdicka Reaction to Reveal the Importance of Metallothionein in Chemotherapy with Platinum Based Cytostatics"@en . "1661-6596" . "11" . . "Fabrik, Ivo" . "246144" . . "International Journal of Molecular Sciences" . . . "I, P(IAA401990701), P(NR9532), S, V, Z(MSM0021622412)" . . "Adam, Vojt\u011Bch" . . "12" . "An Adsorptive Transfer Technique Coupled with Brdicka Reaction to Reveal the Importance of Metallothionein in Chemotherapy with Platinum Based Cytostatics" . "tumor disease; metallothionein; platinum based anticancer drugs; anticancer therapy; resistance; retinoblastoma"@en . "H\u00FAska, Dalibor" . . . . "Babula, Petr" . "1"^^ . . "An Adsorptive Transfer Technique Coupled with Brdicka Reaction to Reveal the Importance of Metallothionein in Chemotherapy with Platinum Based Cytostatics" . "CH - \u0160v\u00FDcarsk\u00E1 konfederace" . "13"^^ . "000285708000004" . . . "Darsov\u00E1, Denisa" . . "Kuka\u010Dka, Ji\u0159\u00ED" . "RIV/00216224:14310/10:00063546!RIV13-MSM-14310___" . . "RIV/00216224:14310/10:00063546" . "14310" .