"c-Myb decreases apoptotic frequency in colon carcinoma cells Cox-2-independently"@en . . . . . . . . "Protein c-Myb sni\u017Euje frekvenci apopt\u00F3zy bun\u011Bk karcinomu st\u0159eva bez \u00FA\u010Dasti cyklooxygen\u00E1zy 2" . "978-80-210-4830-0" . "Masarykova univerzita" . . . "2"^^ . . . "Brno" . . "Brno" . "[395D9143F072]" . . "RIV/00216224:14310/09:00028481" . "4"^^ . . "Bene\u0161, Petr" . "Sborn\u00EDk p\u0159\u00EDsp\u011Bvk\u016F XIII. Setk\u00E1n\u00ED biochemik\u016F a molekul\u00E1rn\u00EDch biolog\u016F" . "2009-01-01+01:00"^^ . "Protein c-Myb sni\u017Euje frekvenci apopt\u00F3zy bun\u011Bk karcinomu st\u0159eva bez \u00FA\u010Dasti cyklooxygen\u00E1zy 2" . "4"^^ . "Protein c-Myb sni\u017Euje frekvenci apopt\u00F3zy bun\u011Bk karcinomu st\u0159eva bez \u00FA\u010Dasti cyklooxygen\u00E1zy 2"@cs . . "Ne\u0161porov\u00E1, Kristina" . . "\u0160marda, Jan" . "P(GA301/09/1115), P(GD204/08/H054), P(IAA501630801), Z(MSM0021622415)" . "RIV/00216224:14310/09:00028481!RIV11-GA0-14310___" . "Kolorekt\u00E1ln\u00ED karcinom p\u0159edstavuje jedno z nej\u010Dast\u011Bj\u0161\u00EDch n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED postihuj\u00EDc\u00ED obyvatele pr\u016Fmyslov\u00FDch zem\u00ED. Proces transformace st\u0159evn\u00EDch bun\u011Bk zahrnuje postupn\u00E9 hromad\u011Bn\u00ED mutac\u00ED a/nebo zm\u011Bny exprese n\u011Bkolika protoonkogen\u016F a n\u00E1dorov\u00FDch supresor\u016F. Jedn\u00EDm z nich je protoonkogen c-myb. Hladina proteinu c-Myb, kter\u00FD funguje jako transkrip\u010Dn\u00ED faktor a pod\u00EDl\u00ED se na regulaci proliferace, diferenciace a apopt\u00F3zy, je v bu\u0148k\u00E1ch st\u0159evn\u00EDch n\u00E1dor\u016F \u010Dasto zv\u00FD\u0161ena. Mezi geny, jejich\u017E exprese je regulov\u00E1na proteinem c-Myb a jejich\u017E zv\u00FD\u0161en\u00E1 aktivita byla tak\u00E9 prok\u00E1z\u00E1na ve st\u0159evn\u00EDch n\u00E1dorech, pat\u0159\u00ED cox-2 k\u00F3duj\u00EDc\u00ED cyklooxygen\u00E1zu 2. Inhibitory Cox-2 jsou pova\u017Eov\u00E1ny za perspektivn\u00ED protin\u00E1dorov\u00E1 l\u00E9\u010Diva. V\u00FDznam aktivace Cox-2 pro pron\u00E1dorov\u00FD \u00FA\u010Dinek proteinu c-Myb ve st\u0159evn\u00EDch bu\u0148k\u00E1ch je tedy z klinick\u00E9ho hlediska zaj\u00EDmav\u00FD a nen\u00ED dosud objasn\u011Bn. C\u00EDlem tohoto projektu je ur\u010Dit funkci proteinu c-Myb v \u0159\u00EDzen\u00ED apopt\u00F3zy st\u0159evn\u00EDch bun\u011Bk a objasnit v\u00FDznam Cox-2 p\u0159i zprost\u0159edkov\u00E1n\u00ED \u00FA\u010Dink\u016F tohoto transkrip\u010Dn\u00EDho faktoru."@cs . . . . "c-Myb decreases apoptotic frequency in colon carcinoma cells Cox-2-independently"@en . . "Kolorekt\u00E1ln\u00ED karcinom p\u0159edstavuje jedno z nej\u010Dast\u011Bj\u0161\u00EDch n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED postihuj\u00EDc\u00ED obyvatele pr\u016Fmyslov\u00FDch zem\u00ED. Proces transformace st\u0159evn\u00EDch bun\u011Bk zahrnuje postupn\u00E9 hromad\u011Bn\u00ED mutac\u00ED a/nebo zm\u011Bny exprese n\u011Bkolika protoonkogen\u016F a n\u00E1dorov\u00FDch supresor\u016F. Jedn\u00EDm z nich je protoonkogen c-myb. Hladina proteinu c-Myb, kter\u00FD funguje jako transkrip\u010Dn\u00ED faktor a pod\u00EDl\u00ED se na regulaci proliferace, diferenciace a apopt\u00F3zy, je v bu\u0148k\u00E1ch st\u0159evn\u00EDch n\u00E1dor\u016F \u010Dasto zv\u00FD\u0161ena. Mezi geny, jejich\u017E exprese je regulov\u00E1na proteinem c-Myb a jejich\u017E zv\u00FD\u0161en\u00E1 aktivita byla tak\u00E9 prok\u00E1z\u00E1na ve st\u0159evn\u00EDch n\u00E1dorech, pat\u0159\u00ED cox-2 k\u00F3duj\u00EDc\u00ED cyklooxygen\u00E1zu 2. Inhibitory Cox-2 jsou pova\u017Eov\u00E1ny za perspektivn\u00ED protin\u00E1dorov\u00E1 l\u00E9\u010Diva. V\u00FDznam aktivace Cox-2 pro pron\u00E1dorov\u00FD \u00FA\u010Dinek proteinu c-Myb ve st\u0159evn\u00EDch bu\u0148k\u00E1ch je tedy z klinick\u00E9ho hlediska zaj\u00EDmav\u00FD a nen\u00ED dosud objasn\u011Bn. C\u00EDlem tohoto projektu je ur\u010Dit funkci proteinu c-Myb v \u0159\u00EDzen\u00ED apopt\u00F3zy st\u0159evn\u00EDch bun\u011Bk a objasnit v\u00FDznam Cox-2 p\u0159i zprost\u0159edkov\u00E1n\u00ED \u00FA\u010Dink\u016F tohoto transkrip\u010Dn\u00EDho faktoru." . "14310" . "Knopfov\u00E1, Lucia" . "337266" . . "c-Myb; Cox-2; apoptosis; colon carcinoma"@en . "Protein c-Myb sni\u017Euje frekvenci apopt\u00F3zy bun\u011Bk karcinomu st\u0159eva bez \u00FA\u010Dasti cyklooxygen\u00E1zy 2"@cs . . "Colon carcinoma belongs to the most frequent tumor diseases in industrial countries. Development of the colon tumors is associated with mutations occurring in protooncogenes and tumor suppressor genes of colon cells. c-myb protooncogene coding for a transcription factor belongs among genes involved in colorectal cancerogenesis. The set of the Myb-targeted genes includes also the cox-2 gene coding for cyclooxygenase 2. Cells of colon tumors often overexpress Cox-2. The aim of this study was to determine the effect of c-Myb overexpression and c-Myb silencing, respectively, on apoptosis in colon carcinoma cell lines HCT116 and HT-29 and to reveal, whether Cox-2 mediates some of c-Myb-induced effects. Our results show, that c-Myb prevents apoptotis in colon carcinoma cells induced by cis-platin and TRAIL. Experiments with Cox-2 selective inhibitors suggest that c-Myb-induced resistance in these cells is not mediated via Cox-2."@en . . .