. . "[9908D5C8DBFF]" . "4"^^ . "Bratislava" . "Zborn\u00EDk abstraktov" . . "osteoclasts; TGF beta; prostate cancer"@en . . "Va\u0148hara, Petr" . . "RIV/00216224:14310/08:00042037" . "4"^^ . . "Karcinom prostaty preferen\u010Dn\u011B metast\u00E1zuje do kost\u00ED, ale mechanizmy, kter\u00E9 sm\u011Bruj\u00ED n\u00E1dorov\u00E9 bu\u0148ky do kostn\u00ED tk\u00E1n\u011B a umo\u017E\u0148uj\u00ED vytv\u00E1\u0159en\u00ED metastatick\u00FDch lo\u017Eisek nejsou objasn\u011Bny. C\u00EDlem t\u00E9to pr\u00E1ce byl popis \u00FA\u010Dinku t\u0159\u00ED cytokin\u016F (TGFbeta, GDF-15, BMP7) rodiny TGFbeta, sekretovan\u00FDch n\u00E1dorov\u00FDmi prostatick\u00FDmi bu\u0148kami my\u0161\u00ED linie LNCaP, na diferenciaci osteoklast\u016F v r\u00E1mci modelov\u00E9ho syt\u00E9mu my\u0161\u00EDch makrof\u00E1g\u016F RAW264.7. Z na\u0161\u00ED pr\u00E1ce vypl\u00FDv\u00E1, \u017Ee zat\u00EDmco TGFbeta stimuluje diferenciaci osteoklast\u016F, GDF-15 a BMP-7 diferenciaci osteoklast\u016F inhibuj\u00ED. Tyto jevy jsme popsali jednak na \u00FArovni vlastn\u00ED morfologie bun\u011Bk, tak i na \u00FArovni exprese n\u011Bkter\u00FDch gen\u016F asociovan\u00FDch s osteoklasty (nap\u0159. CtsK, NFATc1, MITF). Zaj\u00EDmav\u00E9 je, \u017Ee v\u0161echny t\u0159i cytokiny, tedy v\u010Detn\u011B TGFbeta, maj\u00ED supresivn\u00ED \u00FA\u010Dinek na expresi genu pro karbonickou anhydr\u00E1zu 2 (Car2), kter\u00E1 je siln\u011B exprimov\u00E1na b\u011Bhem osteoklastov\u00E9 diferenciace."@cs . "14310" . "Univerzita Komensk\u00E9ho v Bratislave" . . "TGFb proteins secreted by prostate cancer cells modulate osteoclasts differentiation."@en . "Proteiny rodiny TGFbeta sekretovan\u00E9 prostatick\u00FDmi n\u00E1dorov\u00FDmi bu\u0148kami ovliv\u0148uj\u00ED diferenciaci osteoklast\u016F" . "Slab\u00E1kov\u00E1, Eva" . "2"^^ . "Karcinom prostaty preferen\u010Dn\u011B metast\u00E1zuje do kost\u00ED, ale mechanizmy, kter\u00E9 sm\u011Bruj\u00ED n\u00E1dorov\u00E9 bu\u0148ky do kostn\u00ED tk\u00E1n\u011B a umo\u017E\u0148uj\u00ED vytv\u00E1\u0159en\u00ED metastatick\u00FDch lo\u017Eisek nejsou objasn\u011Bny. C\u00EDlem t\u00E9to pr\u00E1ce byl popis \u00FA\u010Dinku t\u0159\u00ED cytokin\u016F (TGFbeta, GDF-15, BMP7) rodiny TGFbeta, sekretovan\u00FDch n\u00E1dorov\u00FDmi prostatick\u00FDmi bu\u0148kami my\u0161\u00ED linie LNCaP, na diferenciaci osteoklast\u016F v r\u00E1mci modelov\u00E9ho syt\u00E9mu my\u0161\u00EDch makrof\u00E1g\u016F RAW264.7. Z na\u0161\u00ED pr\u00E1ce vypl\u00FDv\u00E1, \u017Ee zat\u00EDmco TGFbeta stimuluje diferenciaci osteoklast\u016F, GDF-15 a BMP-7 diferenciaci osteoklast\u016F inhibuj\u00ED. Tyto jevy jsme popsali jednak na \u00FArovni vlastn\u00ED morfologie bun\u011Bk, tak i na \u00FArovni exprese n\u011Bkter\u00FDch gen\u016F asociovan\u00FDch s osteoklasty (nap\u0159. CtsK, NFATc1, MITF). Zaj\u00EDmav\u00E9 je, \u017Ee v\u0161echny t\u0159i cytokiny, tedy v\u010Detn\u011B TGFbeta, maj\u00ED supresivn\u00ED \u00FA\u010Dinek na expresi genu pro karbonickou anhydr\u00E1zu 2 (Car2), kter\u00E1 je siln\u011B exprimov\u00E1na b\u011Bhem osteoklastov\u00E9 diferenciace." . . . . . . . . "TGFb proteins secreted by prostate cancer cells modulate differentiation of osteoclasts."@en . . "Proteiny rodiny TGFbeta sekretovan\u00E9 prostatick\u00FDmi n\u00E1dorov\u00FDmi bu\u0148kami ovliv\u0148uj\u00ED diferenciaci osteoklast\u016F"@cs . "\u0160marda, Jan" . "P(GA301/06/0036), P(GD204/08/H054), Z(MSM0021622415)" . "2008-01-01+01:00"^^ . "Proteiny rodiny TGFbeta sekretovan\u00E9 prostatick\u00FDmi n\u00E1dorov\u00FDmi bu\u0148kami ovliv\u0148uj\u00ED diferenciaci osteoklast\u016F"@cs . "TGFb proteins secreted by prostate cancer cells modulate osteoclasts differentiation."@en . "Sou\u010Dek, Karel" . "978-80-223-2413-7" . . . . . . . "Bratislava, Slovensko" . . "Proteiny rodiny TGFbeta sekretovan\u00E9 prostatick\u00FDmi n\u00E1dorov\u00FDmi bu\u0148kami ovliv\u0148uj\u00ED diferenciaci osteoklast\u016F" . "RIV/00216224:14310/08:00042037!RIV11-MSM-14310___" . "390637" .