"Nuclear factor kappa B (NFkB) is transcription factor that participates in immune and inflammatory response, cell growth, differentiation and apoptosis and can be stimulated by stress, cytokines, free radicals, UV radiation or by bacterial and viral antigens. Deregulation of this transcription regulator was found in cancer, autoimmune diseases, septic shock and viral infection. NFkB protein family consists of 5 proteins (subunits): p50 (NFkB1), p52 (NFkB2), c-Rel, RelB and p65 (RelA). Active transcription factor is homo- or heterodimer. We analyzed the expression of NFkB subunits in macrophage differentiation pathway. BM2 cells were treated with either phorbol ester (TPA) or inhibitor of histon-deacetylases trichostatin A (TSA). Using qRT-PCR, we detected decrease of c-Rel, Rel B and p65 subunits after TPA treatment and significant increase of p50, p65 and c-Rel subunits after TSA treatment. The expression profiles can be linked to differential status of BM2 cells."@en . . . . . "Anal\u00FDza exprese podjednotek NFkB u bun\u011Bk leukemick\u00E9 linie BM2 metodou qRT-PCR"@cs . "\u0160marda, Jan" . "P(GA301/06/0036), P(GD204/08/H054), Z(MSM0021622415)" . "RIV/00216224:14310/08:00024635" . . "356032" . "Anal\u00FDza exprese podjednotek NFkB u bun\u011Bk leukemick\u00E9 linie BM2 metodou qRT-PCR" . "Va\u0148hara, Petr" . . "Expression od NFkB subunits in BM2 monoblasts by quantitative real time PCR"@en . . . . "Kauck\u00E1, Mark\u00E9ta" . . . . "[D2C0AC282DE3]" . "XII. Pracovn\u00ED setk\u00E1n\u00ED biochemik\u016F a molekul\u00E1rn\u00EDch biolog\u016F. Sborn\u00EDk abstrakt\u016F." . "3"^^ . . "14310" . "Anal\u00FDza exprese podjednotek NFkB u bun\u011Bk leukemick\u00E9 linie BM2 metodou qRT-PCR" . "978-80-210-4526-2" . "Nukle\u00E1rn\u00ED faktor kappa B (NFkB) je proteinov\u00FD komplex slou\u017E\u00EDc\u00ED jako transkrip\u010Dn\u00ED faktor, kter\u00FD se nach\u00E1z\u00ED ve v\u011Bt\u0161in\u011B \u017Eivo\u010Di\u0161n\u00FDch bun\u011Bk. NFkB se v\u00FDznamn\u011B pod\u00EDl\u00ED na imunitn\u00ED odpov\u011Bdi, v\u00FDvoji, bun\u011B\u010Dn\u00E9m r\u016Fstu, diferenciaci a apopt\u00F3ze. Deregulace tohoto transkrip\u010Dn\u00EDho faktoru byla zji\u0161t\u011Bna u n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED, z\u00E1n\u011Bt\u016F nebo autoimunitn\u00EDch chorob. Rodina NFkB zahrnuje 5 \u010Dlen\u016F - NFkB-1 (p50), NFkB-2 (p52), RelA (p65), RelB a c-Rel. Funk\u010Dn\u00ED NFkB m\u00E1 podobu homo- nebo heterodimeru, kter\u00FD obsahuje alespo\u0148 jednu transaktiva\u010Dn\u00ED dom\u00E9nu. V t\u00E9to pr\u00E1ci jsme jako model vyu\u017Eili bun\u011B\u010Dnou linii monoblast\u016F BM2 trasformovan\u00FDch onkogenem v-myb. Exprese tohoto onkogenu znemo\u017E\u0148uje dokon\u010Den\u00ED monocytick\u00E9/makrof\u00E1gov\u00E9 dr\u00E1hy. P\u016Fsoben\u00EDm forbolov\u00E9ho esteru TPA nebo inhibitoru histonov\u00FDch deacetyl\u00E1z trichostatinu A (TSA) v\u0161ak BM2 umo\u017E\u0148uje diferencia\u010Dn\u00ED dr\u00E1hu dokon\u010Dit. \u00DAkolem t\u00E9to studie je popis exprese jednotliv\u00FDch podjednotek NFkB po p\u016Fsoben\u00ED TPA a TSA metodou kvantitativn\u00ED RT-PCR." . . . . . "Brno" . "3"^^ . "2008-01-01+01:00"^^ . "Brno" . "Nukle\u00E1rn\u00ED faktor kappa B (NFkB) je proteinov\u00FD komplex slou\u017E\u00EDc\u00ED jako transkrip\u010Dn\u00ED faktor, kter\u00FD se nach\u00E1z\u00ED ve v\u011Bt\u0161in\u011B \u017Eivo\u010Di\u0161n\u00FDch bun\u011Bk. NFkB se v\u00FDznamn\u011B pod\u00EDl\u00ED na imunitn\u00ED odpov\u011Bdi, v\u00FDvoji, bun\u011B\u010Dn\u00E9m r\u016Fstu, diferenciaci a apopt\u00F3ze. Deregulace tohoto transkrip\u010Dn\u00EDho faktoru byla zji\u0161t\u011Bna u n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED, z\u00E1n\u011Bt\u016F nebo autoimunitn\u00EDch chorob. Rodina NFkB zahrnuje 5 \u010Dlen\u016F - NFkB-1 (p50), NFkB-2 (p52), RelA (p65), RelB a c-Rel. Funk\u010Dn\u00ED NFkB m\u00E1 podobu homo- nebo heterodimeru, kter\u00FD obsahuje alespo\u0148 jednu transaktiva\u010Dn\u00ED dom\u00E9nu. V t\u00E9to pr\u00E1ci jsme jako model vyu\u017Eili bun\u011B\u010Dnou linii monoblast\u016F BM2 trasformovan\u00FDch onkogenem v-myb. Exprese tohoto onkogenu znemo\u017E\u0148uje dokon\u010Den\u00ED monocytick\u00E9/makrof\u00E1gov\u00E9 dr\u00E1hy. P\u016Fsoben\u00EDm forbolov\u00E9ho esteru TPA nebo inhibitoru histonov\u00FDch deacetyl\u00E1z trichostatinu A (TSA) v\u0161ak BM2 umo\u017E\u0148uje diferencia\u010Dn\u00ED dr\u00E1hu dokon\u010Dit. \u00DAkolem t\u00E9to studie je popis exprese jednotliv\u00FDch podjednotek NFkB po p\u016Fsoben\u00ED TPA a TSA metodou kvantitativn\u00ED RT-PCR."@cs . . . "2"^^ . . "RIV/00216224:14310/08:00024635!RIV10-MSM-14310___" . "Expression od NFkB subunits in BM2 monoblasts by quantitative real time PCR"@en . "Anal\u00FDza exprese podjednotek NFkB u bun\u011Bk leukemick\u00E9 linie BM2 metodou qRT-PCR"@cs . "Masarykova univerzita" . . "NFkB; BM2; qRT-PCR"@en .