"RIV/00216224:14310/08:00024633" . "Osteoklasty jsou velk\u00E9 mnohojadern\u00E9 bu\u0148ky schopn\u00E9 resorpce mineralizovan\u00E9 kostn\u00ED matrix, kter\u00E9 se pod\u00EDlej\u00ED na udr\u017Eov\u00E1n\u00ED kalciov\u00E9 homeost\u00E1zy. P\u016Fvod osteoklast\u016F je na rozd\u00EDl od ostatn\u00EDch kostn\u00EDch bun\u011Bk odvozen od monocyto-makrof\u00E1gov\u00E9 \u0159ady hematopoetick\u00FDch bun\u011Bk a je \u0159\u00EDzen podobn\u00FDmi transkrip\u010Dn\u00EDmi faktory. Pro diferenciaci osteoklast\u016F je kl\u00ED\u010Dov\u00E1 stimulace cytokiny M-CSF (CSF-1) a RANKL. \u0158ada transkrip\u010Dn\u00EDch faktor\u016F, zn\u00E1m\u00FDch v r\u00E1mci makrof\u00E1gov\u00E9 diferencia\u010Dn\u00ED dr\u00E1hy je nezbytn\u00E1 i pro dokon\u010Den\u00ED osteoklastov\u00E9 diferenciace. Tato pr\u00E1ce sleduje \u010Dasov\u00E9 zm\u011Bny v expresi transkrip\u010Dn\u00EDch (ko)faktor\u016F PU.1, c-myb, c-fos, c-jun, MITF a CBP v z\u00E1vislosti na signalizaci M-CSF-RANKL. V\u00FDsledky ukazuj\u00ED, \u017Ee pro termin\u00E1ln\u00ED procesy diferenciace je nezbytn\u00FD \u00FAtlum exprese gen\u016F c-myb, c-jun a CBP, p\u0159i\u010Dem\u017E gen c-myb nen\u00ED aktivn\u00ED ji\u017E v makrof\u00E1gov\u00E9m st\u00E1diu; c-jun a CBP po prvotn\u00EDm zv\u00FD\u0161en\u00ED exprese v ran\u00E9 f\u00E1zi diferenciace jsou utlumeny na t\u00E9m\u011B\u0159 nulovou hladinu. Exprese gen\u016F k\u00F3duj\u00EDc\u00EDch PU." . "Osteoclasts are large, multinucleated cells responsible for bone resorption and remodelling. Differentiation disorders or impaired regulation of activity lead to serious congenital or acquired diseases. Origin of osteoclasts is hematoipoetic and is driven by similar transcription factors as other blood cell types. Differentiation of osteclasts is usually induced by combination of cytokines M-CSF (CSF-1) and RANKL. This work is focused on expression profiles of transcription factors PU.1, MITF, c-myb, c-jun, c-fos and CBP, together with three osteoclasts markers CtsK, CarII and Integrin b3. Results show, that expression of c-jun, c-Myb and CBP is downregulated in mature osteoclasts and their absence is probably necessary for succesfull terminal differentiation. PU.1, MITF and c-Fos are rather upregulated, which corelates well with previously published data."@en . "Va\u0148hara, Petr" . . "Expresn\u00ED profily vybran\u00FDch transkrip\u010Dn\u00EDch faktor\u016F v pr\u016Fb\u011Bhu osteoklastov\u00E9 diferenciace"@cs . . "Osteoklasty jsou velk\u00E9 mnohojadern\u00E9 bu\u0148ky schopn\u00E9 resorpce mineralizovan\u00E9 kostn\u00ED matrix, kter\u00E9 se pod\u00EDlej\u00ED na udr\u017Eov\u00E1n\u00ED kalciov\u00E9 homeost\u00E1zy. P\u016Fvod osteoklast\u016F je na rozd\u00EDl od ostatn\u00EDch kostn\u00EDch bun\u011Bk odvozen od monocyto-makrof\u00E1gov\u00E9 \u0159ady hematopoetick\u00FDch bun\u011Bk a je \u0159\u00EDzen podobn\u00FDmi transkrip\u010Dn\u00EDmi faktory. Pro diferenciaci osteoklast\u016F je kl\u00ED\u010Dov\u00E1 stimulace cytokiny M-CSF (CSF-1) a RANKL. \u0158ada transkrip\u010Dn\u00EDch faktor\u016F, zn\u00E1m\u00FDch v r\u00E1mci makrof\u00E1gov\u00E9 diferencia\u010Dn\u00ED dr\u00E1hy je nezbytn\u00E1 i pro dokon\u010Den\u00ED osteoklastov\u00E9 diferenciace. Tato pr\u00E1ce sleduje \u010Dasov\u00E9 zm\u011Bny v expresi transkrip\u010Dn\u00EDch (ko)faktor\u016F PU.1, c-myb, c-fos, c-jun, MITF a CBP v z\u00E1vislosti na signalizaci M-CSF-RANKL. V\u00FDsledky ukazuj\u00ED, \u017Ee pro termin\u00E1ln\u00ED procesy diferenciace je nezbytn\u00FD \u00FAtlum exprese gen\u016F c-myb, c-jun a CBP, p\u0159i\u010Dem\u017E gen c-myb nen\u00ED aktivn\u00ED ji\u017E v makrof\u00E1gov\u00E9m st\u00E1diu; c-jun a CBP po prvotn\u00EDm zv\u00FD\u0161en\u00ED exprese v ran\u00E9 f\u00E1zi diferenciace jsou utlumeny na t\u00E9m\u011B\u0159 nulovou hladinu. Exprese gen\u016F k\u00F3duj\u00EDc\u00EDch PU."@cs . . "[D6A8800C7610]" . . . "14310" . "XII. Pracovn\u00ED setk\u00E1n\u00ED biochemik\u016F a molekul\u00E1rn\u00EDch biolog\u016F. Sborn\u00EDk abstrakt\u016F." . "Expresn\u00ED profily vybran\u00FDch transkrip\u010Dn\u00EDch faktor\u016F v pr\u016Fb\u011Bhu osteoklastov\u00E9 diferenciace" . . "Expression profiles of certain transcription factors in osteoclast differentiation"@en . . "\u0160marda, Jan" . "Brno" . "Expresn\u00ED profily vybran\u00FDch transkrip\u010Dn\u00EDch faktor\u016F v pr\u016Fb\u011Bhu osteoklastov\u00E9 diferenciace" . "P(GA301/06/0036), P(GD204/08/H054), Z(MSM0021622415)" . "Brno" . . . "RIV/00216224:14310/08:00024633!RIV11-GA0-14310___" . . . "Masarykova univerzita" . . "367406" . "2"^^ . . . . "978-80-210-4526-2" . . "Expresn\u00ED profily vybran\u00FDch transkrip\u010Dn\u00EDch faktor\u016F v pr\u016Fb\u011Bhu osteoklastov\u00E9 diferenciace"@cs . "transcription factors osteoclasts qRT-PCR"@en . "2008-01-01+01:00"^^ . "2"^^ . "Expression profiles of certain transcription factors in osteoclast differentiation"@en . . . "2"^^ .