"5"^^ . "Cahov\u00E1, Kate\u0159ina" . . "419712" . "1521-4109" . "10"^^ . "Fojta, Miroslav" . "Mozga, Tom\u00E1\u0161" . "[B9D1BE2845AB]" . "DNA damage by CrV and/or CrIV intermediates of CrVI electrochemical reduction was detected using a supercoiled DNA-modified mercury electrode. A signal sensitive to formation of DNA strand breaks, AC voltammetric DNA peak 3, increased due to incubation of the DNA-modified electrode in micromolar solutions of CrVI at potentials sufficiently negative for CrVI reduction. Damage to DNA in solutions containing CrVI and a chemical reductant (ascorbic acid, AA) was observed only at relatively high chromium concentrations (hundreds of M). To eliminate interferences of excess CrVI in measurements of guanine electrochemical signals, a magnetoseparation double surface electrochemical technique was introduced. Using this approach, DNA damage in solution was detected for 50-250 M CrVI upon addition of 1 mM AA."@en . "Pivo\u0148kov\u00E1, Hana" . "Electrochemical Sensing of Chromium-Induced DNA Damage: DNA Strand Breakage by Intermediates of Chromium(VI) Electrochemical Reduction." . "x" . . . . "1"^^ . "Vacek, Jan" . "19" . "000250129100013" . . . . . "14310" . . . . "Electrochemical Sensing of Chromium-Induced DNA Damage: DNA Strand Breakage; Intermediates of Chromium(VI); Electrochemical Reduction."@en . "Electrochemical Sensing of Chromium-Induced DNA Damage: DNA Strand Breakage by Intermediates of Chromium(VI) Electrochemical Reduction."@en . "DNA damage by CrV and/or CrIV intermediates of CrVI electrochemical reduction was detected using a supercoiled DNA-modified mercury electrode. A signal sensitive to formation of DNA strand breaks, AC voltammetric DNA peak 3, increased due to incubation of the DNA-modified electrode in micromolar solutions of CrVI at potentials sufficiently negative for CrVI reduction. Damage to DNA in solutions containing CrVI and a chemical reductant (ascorbic acid, AA) was observed only at relatively high chromium concentrations (hundreds of M). To eliminate interferences of excess CrVI in measurements of guanine electrochemical signals, a magnetoseparation double surface electrochemical technique was introduced. Using this approach, DNA damage in solution was detected for 50-250 M CrVI upon addition of 1 mM AA." . "RIV/00216224:14310/07:00022812" . "RIV/00216224:14310/07:00022812!RIV10-MSM-14310___" . "P(GA203/07/1195), P(LC06010), P(LC06035), Z(AV0Z50040507), Z(AV0Z50040702)" . "Electrochemical Sensing of Chromium-Induced DNA Damage: DNA Strand Breakage by Intermediates of Chromium(VI) Electrochemical Reduction."@en . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "Electrochemical Sensing of Chromium-Induced DNA Damage: DNA Strand Breakage by Intermediates of Chromium(VI) Electrochemical Reduction." . . . "ELECTROANALYSIS" . . . . . . .