"33" . "Changes of AhR-mediated activity of humic substances after irradiation" . . "3"^^ . . . "Changes of AhR-mediated activity of humic substances after irradiation"@en . "[372EB20D9845]" . "Humic substances (HS) and natural organic matter (NOM) are natural organic compounds ubiquitous in the environment. However, some studies indicate that both HS and NOM can act as xenobiotics, e.g. induce hormone like effects in fish, amphibians and invertebrates. Molecules of these substances contain a number of aromatic rings and conjugated double bonds, the so called chromophores. Irradiation of dissolved HS and NOM can lead to a series of photochemical reactions which can act on these substances itself, or on other substances present in aquatic environment along with HS and NOM such as e.g. xenobiotics. In our previous study, we have found significant interactions of five humic acids (HA) with cytosolic aryl hydrocarbon receptor (AhR) in an in vitro bioassay based on H4IIEluc cells. In the present study, we have studied the changes in AhR mediated activities both of HS and NOM after irradiation that simulated natural solar light." . "P(GP525/05/P160), Z(MSM0021622412)" . "14310" . . "33" . "0160-4120" . "2"^^ . . "Changes of AhR-mediated activity of humic substances after irradiation"@en . "NL - Nizozemsko" . "RIV/00216224:14310/07:00020354!RIV10-MSM-14310___" . . "Humic substances (HS) and natural organic matter (NOM) are natural organic compounds ubiquitous in the environment. However, some studies indicate that both HS and NOM can act as xenobiotics, e.g. induce hormone like effects in fish, amphibians and invertebrates. Molecules of these substances contain a number of aromatic rings and conjugated double bonds, the so called chromophores. Irradiation of dissolved HS and NOM can lead to a series of photochemical reactions which can act on these substances itself, or on other substances present in aquatic environment along with HS and NOM such as e.g. xenobiotics. In our previous study, we have found significant interactions of five humic acids (HA) with cytosolic aryl hydrocarbon receptor (AhR) in an in vitro bioassay based on H4IIEluc cells. In the present study, we have studied the changes in AhR mediated activities both of HS and NOM after irradiation that simulated natural solar light."@en . . "Giesy, John Paul" . "6"^^ . . "000248273700013" . . . "Humic acids; Ah receptor; H4IIE-luc; Absorbance; NOM"@en . "413249" . . . . . . "Hilscherov\u00E1, Kl\u00E1ra" . . "Bittner, Michal" . . . "Environment International" . . "RIV/00216224:14310/07:00020354" . . "Changes of AhR-mediated activity of humic substances after irradiation" .